Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD [0.03%]
西地那非对慢性阻塞性肺疾病患者运动时的肺血管动力学和运动能力的急性影响
Sebastiaan Holverda,Heleen Rietema,Harm J Bogaard et al.
Sebastiaan Holverda et al.
Background: We investigated in chronic obstructive pulmonary disease (COPD) patients whether a single dose of sildenafil can attenuate the exercise-induced increase in pulmonary artery pressure, thereby allowing augmentat...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(3):558-64. DOI:10.1016/j.pupt.2008.01.012 2008
Charles G Plopper,Dallas M Hyde
Charles G Plopper
This review evaluates the current status of information regarding the nonhuman primate as an experimental model for defining mechanisms of chronic airways disease in humans, using the concept of the epithelial-mesenchymal trophic unit (EMTU...
William M Abraham
William M Abraham
Sheep naturally allergic to Ascaris suum antigen have been used to study the pathophysiology of asthma and more recently allergic rhinitis, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The utility of the model as it rel...
Richard W Chapman
Richard W Chapman
Dogs have been extensively used to model the important components of asthma and COPD. Many of the key features of human asthma such as reversible airflow obstruction, pulmonary inflammation, airway hyperresponsiveness and cough are demonstr...
Joanne L Wright,Andrew Churg
Joanne L Wright
Animal models have definite utility in the study of chronic obstructive pulmonary disease. However, choice of model must be determined with the full knowledge of their value, or potential limitations.
Tolerability of high cumulative doses of the HFA modulite beclomethasone dipropionate/formoterol combination inhaler in asthmatic patients [0.03%]
高剂量HFA模件布地奈德福莫特罗联合吸入剂治疗哮喘患者的耐受性研究
Dave Singh,Annalisa Piccinno,Zoe Borrill et al.
Dave Singh et al.
The corticosteroid beclomethasone dipropionate (BDP) has been formulated with the long acting beta agonist formoterol (BDP/formoterol 100 microg/6 microg, Foster) in a single inhaler using Modulite technology. We have investigated the acute...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(3):551-7. DOI:10.1016/j.pupt.2008.01.001 2008
MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers [0.03%]
PDE4抑制剂MK-0873不影响对健康男性志愿者的茶碱药代动力学
J D Boot,S L De Haas,J M A Van Gerven et al.
J D Boot et al.
Background: MK-0873 is a novel selective phosphodiesterase-4 inhibitor, which has been in development for the treatment of chronic obstructive pulmonary disease (COPD). In this indication, theophylline is still an importa...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(3):573-7. DOI:10.1016/j.pupt.2008.01.009 2008
Current progress in cystic fibrosis: is this a disease elusive to therapy? [0.03%]
囊性纤维化研究进展：该病难以治疗吗？
Claire Brown
Claire Brown
Inflammatory responses after endothelin B (ETB) receptor activation in human monocytes: new evidence for beneficial anti-inflammatory potency of ETB-receptor antagonism [0.03%]
人单核细胞中内皮素受体B活化后的炎症反应：ETB受体拮抗药的抗炎作用的新证据
Uwe R Juergens,Kurt Racké,Sakir Uen et al.
Uwe R Juergens et al.
Endothelin (ET) stimulates potent ETA/ETB receptors important in the pathogenesis of pulmonary arterial hypertension (PAH) and fibrosis. Though therapy with ET-receptor antagonists is well established uncertainty exists whether selective ET...
Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol [0.03%]
磷酸二酯酶4抑制剂延迟人在和不在沙丁胺醇情况下的人类嗜酸性粒细胞和中性粒细胞的凋亡
Jouni Parkkonen,Hannele Hasala,Eeva Moilanen et al.
Jouni Parkkonen et al.
In asthma and chronic obstructive pulmonary disease (COPD), the number of eosinophils and neutrophils in the lung is increased. One described mechanism leading to the impaired clearance of these cells from the lung is the delay in their pro...