Activated eosinophils stimulate endothelin-1 release from airway epithelial cells by direct adherence via adhesion molecules [0.03%]
活化的嗜酸性粒细胞通过粘附分子与气道上皮细胞直接黏附刺激内皮素-1的释放
T Endo,Y Uchida,A Nomura et al.
T Endo et al.
Endothelin-1 (ET-1), synthesized in airway epithelial cells, has a potent constrictive action on airway smooth muscle. In this study, we investigated the effect of eosinophils on ET-1 release from guinea pig cultured tracheal epithelial cel...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(2):81-7. DOI:10.1006/pupt.1997.0078 1997
The role of potassium channels in the inhibitory effects of beta 2-adrenoceptor agonists on DNA synthesis in human cultured airway smooth muscle [0.03%]
β₂-肾上腺素受体激动剂对人支气管平滑肌细胞DNA合成抑制作用的钾通道机制研究
K M Gillzan,A G Stewart
K M Gillzan
Opening of calcium-dependent K+ channels by beta 2-adrenoceptor agonists has been shown to contribute to their smooth muscle relaxant activity. In this study, the influence of K+ channel activity on human cultured airway smooth muscle proli...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(2):71-9. DOI:10.1006/pupt.1997.0077 1997
D Spina,C P Page,J Morley et al.
D Spina et al.
Clinical observations both claim and refute sublingual absorption of salbutamol. To resolve this issue, the capacity of salbutamol to inhibit substantial bronchoconstrictor responses to histamine has been defined for both intravenous inject...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(2):67-9. DOI:10.1006/pupt.1997.0080 1997
Colchicine does not ameliorate bleomycin-induced pulmonary injury in hamsters [0.03%]
秋水仙碱不能改善 hamster 肺泡炎模型的肺损伤
A Ben Yehuda,I S Lossos,R Or et al.
A Ben Yehuda et al.
We have evaluated the effect of colchicine, a potential antifibrotic drug, on bleomycin-induced pulmonary inflammation in hamsters. Pulmonary injury was induced by a single intratracheal (IT) instillation of bleomycin (bleo). Four groups of...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(1):61-5. DOI:10.1006/pupt.1997.0076 1997
Changing the oxygen tension alters the ability of bronchodilators to protect against methacholine-induced challenge in bovine isolated bronchial rings [0.03%]
氧分压的改变影响支气管扩张剂对牛分离支气管环甲基胆碱激发损伤保护作用的研究
R A Clayton,J E Nally,N C Thomson et al.
R A Clayton et al.
The ability of atrial natriuretic peptide, salbutamol, sodium nitroprusside and isosorbide dinitrate to protect against challenge with methacholine in bovine isolated bronchi was compared in different O2 tensions. Perfusing the Krebs-Hensel...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(1):51-60. DOI:10.1006/pupt.1997.0070 1997
Salmeterol inhibits the allergen-induced mononuclear cell proliferation and downregulates GM-CSF release and HLA-DR expression by monocytes [0.03%]
沙美特罗抑制变应原诱导的单个核细胞增殖并下调单核细胞的GM-CSF释放及HLA-DR表达
S Oddera,M Silvestri,L Scarso et al.
S Oddera et al.
beta 2-adrenoceptor agonists are known to attenuate several functions of human mononuclear cells in response to activation. Since monocytes and lymphocytes play a major pathogenetic role in allergic asthma, this study was designed to evalua...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(1):43-9. DOI:10.1006/pupt.1997.0073 1997
The effect of hydrogen peroxide on hypoxia, prostaglandin F2 alpha and potassium chloride induced contractions in isolated rat pulmonary arteries [0.03%]
双氧水对大鼠肺动脉缺血、前列腺素F2α及氯化钾所致收缩的影响
R D Jones,J S Thompson,A H Morice
R D Jones
We have investigated the action of the product of the enzyme NADPH oxidase; hydrogen peroxide (H2O2), on the first phase of the hypoxic contraction, prostaglandin F2 alpha (PGF2 alpha)-induced contractions and potassium chloride (KCl)-induc...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(1):37-42. DOI:10.1006/pupt.1997.0071 1997
Functional characterization of receptors for cysteinyl-leukotrienes in sheep trachealis muscle [0.03%]
绵羊气管肌肉半胱氨酰白三烯受体的功能表征
E W Jonsson
E W Jonsson
Cysteinyl-leukotrienes (CysLTs: LTC4, LTD4 and LTE4) are inflammatory mediators which significantly contribute to the airway obstruction in asthma. At least two distinct receptor subtypes exist for cysteinyl-leukotrienes, the CysLT1- and Cy...
Comparative Study
Pulmonary pharmacology & therapeutics. 1997;10(1):29-36. DOI:10.1006/pupt.1997.0075 1997
Recombinant human DNase (rhDNase) influences phospholipid composition, surface activity, rheology and consecutively clearance indices of cystic fibrosis sputum [0.03%]
重组人脱氧核糖核酸酶(rhDNase)影响囊性纤维化痰液的磷脂组成、表面活性、流变学以及继发清除指标
M Griese,E M App,A Duroux et al.
M Griese et al.
Cystic fibrosis (CF) is caused by mutation in the gene for the CF transmembrane conductance regulator which leads to massive, abnormally viscous, purulent sputum, chronic destructive endobronchitis and early death. Purified recombinant huma...
P J Barnes
P J Barnes