Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs [0.03%]
吸入一氧化氮预处理可预防大鼠肺部的高氧和缺血再灌注损伤
Thomas Waldow,Wolfgang Witt,André Ulmer et al.
Thomas Waldow et al.
Since the generation of nitric oxide (NO) is an essential step in the trigger phase of ischemic preconditioning, short-term inhalation of NO before ischemia should ameliorate ischemia/reperfusion (I/R) injury of the lung. We tested this hyp...
Sandra Keir,Clive Page
Sandra Keir
No single animal model is able to reproduce all the features of human asthma. However, the similarities between neonatally immunised rabbits and human asthma highlight the value of this model in the investigation of asthma pathophysiology a...
Steven D Shapiro
Steven D Shapiro
Genetic manipulation in mice often combined with models of human disease has allowed investigators to dissect specific disease pathways. These tools have taught us much about the pathogenesis of chronic obstructive pulmonary disease (COPD)....
Anti-inflammatory modulation of chronic airway inflammation in the murine house dust mite model [0.03%]
抗炎调节法调控小鼠尘螨模型慢性气道炎症
Kristina Ulrich,Jennifer S Hincks,Roddy Walsh et al.
Kristina Ulrich et al.
Asthma affects 300 million people worldwide and continues to be a major cause of morbidity and mortality. Disease relevant animal models of asthma are required for benchmarking of novel therapeutic mechanisms in comparison to established cl...
Bronchodilator efficacy of the fixed combination of ipratropium and albuterol compared to albuterol alone in moderate-to-severe persistent asthma [0.03%]
联合使用异丙托溴铵和沙丁胺醇治疗中至重度持续性哮喘的支气管扩张效果与单用沙丁胺醇比较：一项随机双盲临床试验
Arthur F Gelb,Jill Karpel,Robert A Wise et al.
Arthur F Gelb et al.
Background: The potential of anticholinergics to provide bronchodilatory benefits over short-acting beta(2)-agonists (SABA) alone in patients with moderate-to-severe persistent asthma has not been well defined. ...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):630-6. DOI:10.1016/j.pupt.2008.02.005 2008
M G Matera,L Calzetta,A Sanduzzi et al.
M G Matera et al.
It has been demonstrated in mammals that the airway hyper-responsiveness, which accompanies viral infections, is the result of increased reflex bronchoconstriction due to inhibition of muscarinic prejunctional receptors, which belong to M2 ...
Sam So Eum, a herb extract, as the remedy for allergen-induced asthma in mice [0.03%]
抗原诱导的小鼠哮喘模型中草药萨姆苏姆(Sam So Eum)的防治作用研究
Su Jin Cho,Hyung Woo Kim,Bu-Yeo Kim et al.
Su Jin Cho et al.
We studied administering Sam So Eum (SSE) as a herbal medicine to treat asthma in mice and we discussed the mechanism of restoring the immuno-modulating cytokines such as IL-10 and IFN-gamma. The mice treated with SSE did not show any signi...
Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: a randomized placebo-controlled trial [0.03%]
罗氟司特可减轻健康受试者支气管段内给予内毒素后的肺部炎症：一项随机、安慰剂对照试验
Jens M Hohlfeld,Kerstin Schoenfeld,Mehyar Lavae-Mokhtari et al.
Jens M Hohlfeld et al.
Rationale: Roflumilast, an investigational, targeted phosphodiesterase 4 inhibitor, reduces the in vitro and in vivo inflammatory activity of cells such as neutrophils, eosinophils, macrophages, and monocytes. ...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):616-23. DOI:10.1016/j.pupt.2008.02.002 2008
Toxicity of prolonged high dose inhaled PGE1 in ventilated neonatal pigs [0.03%]
长时间高剂量吸入PGE1对呼吸机支持的新生猪的毒性作用研究
Beena G Sood,Elizabeth J Dawe,Krishna Rao Maddipati et al.
Beena G Sood et al.
Objective: To study the toxicity of inhaled PGE1 (IPGE1) in healthy ventilated piglets. Methods: Mechanically ventilated anesthetized p...
Introduction to the pulmonary research group's symposium upper airway disease: clinical and research perspectives [0.03%]
呼吸道疾病：临床和研究视角
Michel R Corboz,Jonathan E Phillips,Lawrence de Garavilla
Michel R Corboz