The forgotten message from gold: FVC is a primary clinical outcome measure of bronchodilator reversibility in COPD [0.03%]
被遗忘的黄金标准信息：FVC是COPD中支气管扩张剂逆转的主要临床结果测量指标
Helmi Ben Saad,Christian Préfaut,Zouhair Tabka et al.
Helmi Ben Saad et al.
Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends the use of forced expiratory volume in 1s (FEV(1)) to assess airways reversibility. The American Thoracic Society (ATS) and the Euro...
Exhaled nitric oxide monitoring in COPD using a portable analyzer [0.03%]
便携式呼出气一氧化氮测定在慢性阻塞性肺疾病中的应用研究
Guglielmo de Laurentiis,Mauro Maniscalco,Flavia Cianciulli et al.
Guglielmo de Laurentiis et al.
Background: The exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation in asthma. A very recent statement has suggested FeNO as potential outcome in chronic obstructive pulmonary disease (COPD). Recen...
Comparative Study
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):689-93. DOI:10.1016/j.pupt.2008.04.006 2008
A comparative study of grape seed extract and vitamin E effects on silica-induced pulmonary fibrosis in rats [0.03%]
葡萄籽提取物和维生素E对硅致大鼠肺纤维化的影响比较研究
Ali A Hemmati,Zahra Nazari,Mehdi Samei
Ali A Hemmati
Due to the production of reactive oxygen species (ROS), oxidative stress has been implicated in the pathogenesis of silica-induced lung fibrosis. So it is hypothesized that grape seed extract (GSE) or vitamin E (Vit E) as antioxidants may a...
Comparative Study
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):668-74. DOI:10.1016/j.pupt.2008.04.004 2008
Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: response by beta-agonist reversibility [0.03%]
福莫特罗/丙酸氟替卡松及溴化异丙托品/沙丁胺醇对慢性阻塞性肺疾病肺功能和症状的改善：β受体激动剂反应性回复的影响
Eugene R Bleecker,Amanda Emmett,Glenn Crater et al.
Eugene R Bleecker et al.
This retrospective analysis of data from two multi-center, randomized, double-blind, parallel group studies compared the efficacy of fluticasone propionate/salmeterol (FSC) 250/50 mcg twice daily with ipratropium bromide/albuterol (IB/ALB) ...
Comparative Study
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):682-8. DOI:10.1016/j.pupt.2008.04.003 2008
Interleukin-1beta up-regulates tumor necrosis factor receptors in the mouse airways [0.03%]
肿瘤坏死因子受体在小鼠呼吸道中的调控机制研究
Lars Olaf Cardell,Rolf Uddman,Yaping Zhang et al.
Lars Olaf Cardell et al.
Cytokines like interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), released during the inflammatory process, play important roles in the development of airway hyperresponsiveness. The effects of these cytokines are medi...
Fulvio Braido,Michele Bellotti,Andrea De Maria et al.
Fulvio Braido et al.
Streptococcus pneumoniae pathologies represent a health problem of primary importance worldwide in terms of morbidity, mortality, and costs. S. pneumoniae is the main aetiological agent of bacterial pneumonia, and is frequently involved in ...
A pharmacokinetic/pharmacodynamic study comparing arformoterol tartrate inhalation solution and racemic formoterol dry powder inhaler in subjects with chronic obstructive pulmonary disease [0.03%]
比较沙美特罗酒石酸吸入溶液和福莫特尔粉吸入剂治疗慢性阻塞性肺病患者的药代动力学及药效学研究
J Kharidia,C M Fogarty,C F Laforce et al.
J Kharidia et al.
Background: Arformoterol is a single-isomer (R,R-formoterol) nebulized long-acting beta(2)-agonist approved for use in patients with chronic obstructive pulmonary disease (COPD). Exposure (plasma concentrations of (R,R)-f...
Development and characterisation of a novel and rapid lung eosinophil influx model in the rat [0.03%]
一种新型且快速的啮齿动物肺嗜酸性粒细胞浸润模型的开发与表征
Melanie Werner-Klein,Rolf Göggel,Andreas Westhof et al.
Melanie Werner-Klein et al.
Eosinophils play a major role in the development and severity of asthma. Robust and rapid preclinical animal models are desirable to profile novel therapeutics inhibiting the influx of eosinophils into the airways. To develop a rapid, airwa...
Once-daily inhaled glucocorticosteroid administration in controlled asthma patients [0.03%]
每日一次吸人皮质激素治疗控制期哮喘患者
Hirotsugu Hasegawa,Naoki Inui,Tomoyuki Fujisawa et al.
Hirotsugu Hasegawa et al.
Background: Inhaled glucocorticosteroids are usually administered in two equal daily doses. To simplify the method of treatment, once-daily administration has been used. However, little information regarding whether once-...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Aug;21(4):663-7. DOI:10.1016/j.pupt.2008.03.001 2008
Brendan J Canning,Yangling Chou
Brendan J Canning
The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human an...