Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension [0.03%]
西地那非与吸入性曲前列尼尔联合用于肺动脉高压的急性血流动力学和气体交换效应
Robert Voswinckel,Frank Reichenberger,Beate Enke et al.
Robert Voswinckel et al.
Background: Inhaled treprostinil was recently developed for the treatment of pulmonary arterial hypertension (PAH). We investigated the safety and acute haemodynamic effects of the combination oral sildenafil and inhaled ...
Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis [0.03%]
自由基清除剂在抗博莱霉素诱导的大鼠肺纤维化中的双向作用
Masaki Fujita,Yuichi Mizuta,Satoshi Ikegame et al.
Masaki Fujita et al.
Oxidative stress plays a critical role in the development of pulmonary fibrosis. However, the effects of treatment with anti-oxidant agents against pulmonary fibrosis have not yet been thoroughly investigated. In this study, the effect of M...
Nebulized formoterol fumarate: Dose selection and pharmacokinetics [0.03%]
福莫特罗富马酸酯雾化溶液：剂量选择和药代动力学研究
Nicholas J Gross,Edward Kerwin,Bernard Levine et al.
Nicholas J Gross et al.
To determine a dose of nebulized formoterol fumarate inhalation solution (FFIS) comparable to that of the marketed formoterol fumarate dry powder inhaler (FA, 12microg), two crossover studies were conducted in subjects with COPD. Study 1 wa...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Oct;21(5):818-23. DOI:10.1016/j.pupt.2008.07.002 2008
Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction [0.03%]
冷受体激动剂薄荷醇和辣椒素抑制气道平滑肌收缩
Satoru Ito,Hiroaki Kume,Akira Shiraki et al.
Satoru Ito et al.
Menthol, known as a cold receptor agonist, has widely been used in the relief of respiratory symptoms such as coughing and chest congestion. Previous studies have demonstrated that menthol reduces bronchoconstriction and airway hyperrespons...
Fluticasone or montelukast for preschool children with asthma-like symptoms: Randomized controlled trial [0.03%]
氟替卡松与孟鲁司特治疗哮喘样症状的学龄前儿童：随机对照试验
Elisabeth M W Kooi,Siebrig Schokker,H Marike Boezen et al.
Elisabeth M W Kooi et al.
Rationale: Beneficial effects of anti-inflammatory therapy such as fluticasone propionate (FP) and montelukast (Mk) have been demonstrated in preschool children with asthma. However, comparative studies are lacking in thi...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Oct;21(5):798-804. DOI:10.1016/j.pupt.2008.06.004 2008
Different angiogenic CXC chemokine levels in bronchoalveolar lavage fluid after interferon gamma-1b therapy in idiopathic pulmonary fibrosis patients [0.03%]
干扰素γ-1b治疗特发性肺纤维化患者后支气管肺泡灌洗液中不同的血管生成CXC细胞因子水平
Katerina M Antoniou,Nikolaos Tzanakis,Eleni G Tzortzaki et al.
Katerina M Antoniou et al.
Background and aim: Pulmonary fibrosis is a devastating disease with few treatment options. Angiogenesis that leads to aberrant vascular remodeling is regulated by an opposing balance of angiogenic and angiostatic factors...
Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity [0.03%]
吸入乙醇增强辣椒素诱发的呼吸道高反应患者的咳嗽反射
Eva Millqvist,Ewa Ternesten-Hasséus,Mats Bende
Eva Millqvist
A suggested explanation for airway symptoms induced by chemicals and scents is sensory hyperreactivity (SHR) of airway mucosal nerves. Patients with SHR have increased cough sensitivity to inhaled capsaicin, mediated by transient receptor p...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008 Oct;21(5):794-7. DOI:10.1016/j.pupt.2008.06.002 2008
Use of respiratory medication in five Latin American cities: The PLATINO study [0.03%]
拉丁美洲五个城市呼吸系统用药使用情况调查：PLATINO研究
Maria Montes de Oca,Carlos Tálamo,Rogelio Perez-Padilla et al.
Maria Montes de Oca et al.
Background: There is scanty information regarding respiratory medication prescription pattern in Latin America. We examined the use of bronchodilators and corticosteroids in a population-based study conducted in five Lati...
Multicenter Study
Pulmonary pharmacology & therapeutics. 2008 Oct;21(5):788-93. DOI:10.1016/j.pupt.2008.06.003 2008
Pharmacological characterization of 3-azabicyclo[3,2,1] octane-1-yl-l-leucyl-d-tryptophanyl-d-4-Cl-phenylalanine: A novel ET(A) receptor-selective antagonist [0.03%]
3-氮杂双环[3.2.1]辛烷-1-基-L-亮氨-D-色氨-D-4-氯苯丙氨酸的药理学研究：一种新型的ET(A)受体选择性拮抗剂
Xin Li,Ke-Liang Liu,Jian-Quan Zheng et al.
Xin Li et al.
Background and objectives: Pulmonary hypertension is a kind of disease associated with a very high rate of mortality. There are not many effective drugs for the treatment of pulmonary hypertension. Treatment with ET-1 rec...
Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection [0.03%]
ghrelin治疗可抑制慢性呼吸道感染患者气道中以中性粒细胞为主的炎症反应
Tsuyoshi Kodama,Jun-Ichi Ashitani,Nobuhiro Matsumoto et al.
Tsuyoshi Kodama et al.
Background: Persistent neutrophil influx into the airways is a characteristic of chronic respiratory infection and contributes to the deterioration of pulmonary function. Ghrelin is a novel growth hormone (GH)-releasing p...