Michael J Carr
Michael J Carr
The dearth of antitussives in development reflects the broad availability of over-the-counter antitussives. However, a key finding using newly developed cough monitoring systems is a lack of efficacy versus placebo of currently available an...
Milos Tatar,Jana Plevkova,Mariana Brozmanova et al.
Milos Tatar et al.
The diseases of the nose and paranasal sinuses (rhinosinusitis) often in combination with asthma and gastroesophageal reflux are common causes of chronic cough in patients with normal chest radiograph. The relationships between rhinosinusit...
The urge-to-cough and cough motor response modulation by the central effects of nicotine [0.03%]
尼古丁的中枢效应诱发咳嗽及对咳嗽运动反应的调节作用
Paul W Davenport,Andrea Vovk,Rita K Duke et al.
Paul W Davenport et al.
The urge-to-cough is a respiratory sensation that precedes the cough motor response. Since affective state modulates the perception of respiratory sensations such as dyspnoea, we wanted to test whether nicotine, an anxiolytic, would modulat...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2009 Apr;22(2):82-9. DOI:10.1016/j.pupt.2008.11.013 2009
Faster onset of action of formoterol versus salmeterol in patients with chronic obstructive pulmonary disease: a multicenter, randomized study [0.03%]
福莫特罗治疗慢性阻塞性肺病起效时间快于沙美特罗的多中心随机研究
Claudia Cote,James L Pearle,Amir Sharafkhaneh et al.
Claudia Cote et al.
Background: Chronic obstructive pulmonary disease (COPD) is a growing public health problem that has increased in recent years. It similarly affects men and women, especially those who smoke. The goals of COPD pharmacothe...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2009 Feb;22(1):44-9. DOI:10.1016/j.pupt.2008.11.010 2009
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension [0.03%]
用于治疗肺动脉高压的曲前列环素吸入剂型及其给药方法
Robert Voswinckel,Frank Reichenberger,Henning Gall et al.
Robert Voswinckel et al.
Background: The stable prostanoid analogue treprostinil is approved as continuous infusion for treatment of pulmonary arterial hypertension. Unique drug characteristics may render this prostanoid feasible for inhalation t...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2009 Feb;22(1):50-6. DOI:10.1016/j.pupt.2008.11.009 2009
Ans Pauwels,Kathleen Blondeau,Lieven Dupont et al.
Ans Pauwels et al.
Gastroesophageal reflux (GER) is one of the three most common causes of chronic unexplained cough. Diagnosing GER-related cough is challenging since many patients do not have esophagitis or an increased esophageal acid exposure during 24 h ...
Peter G Gibson,Anne E Vertigan
Peter G Gibson
Chronic cough may persist despite systematic evaluation and medical treatment of known associated diseases such as asthma, rhinitis, and gastro-esophageal reflux. These patients have refractory chronic cough and many exhibit laryngeal hyper...
Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats [0.03%]
黑籽油通过抑制t细胞增殖缓解大鼠过敏性气道炎症
Muhammad Shahzad,Xudong Yang,M B Raza Asim et al.
Muhammad Shahzad et al.
The black seeds, from the Ranunculaceae family, have been traditionally used by various cultures as a natural remedy for several ailments. In this study, we examined the effect of black seed oil as an immunomodulator in a rat model of aller...
Raffaele Gatti,Eunice Andre,Campi Barbara et al.
Raffaele Gatti et al.
Ethanol is a chemical irritant able to induce a large variety of effects in the airways. It has been reported that ethanol sensitizes the transient receptor potential vanilloid-1 (TRPV1) to various stimuli and inhalation of ethanol enhances...
L McGarvey,P McKeagney,L Polley et al.
L McGarvey et al.
Cough reflex hypersensitization is a key feature in patients with troublesome cough. The clinical consequence of this hypersensitive state is typified by bouts of coughing often triggered by low threshold stimuli encountered by the patient ...