Hiroshi Ouchi,Masaki Fujita,Satoshi Ikegame et al.
Hiroshi Ouchi et al.
Matrix metalloproteinases (MMPs) expression plays a critical role in extracellular matrix deposition. Although several pieces of evidence have so far indicated that gelatinase contributes to the development of pulmonary fibrosis, the role o...
Robert Foronjy,Alison Wallace,Jeanine D&#x;Armiento
Robert Foronjy
COPD is one of the leading causes of death worldwide and the age-adjusted mortality for this disease has risen significantly over the past 30 years. Current pharmacological treatments do not effectively address the inflammatory and apoptoti...
Therapeutic effects of exogenous surfactant enriched with dextran in newborn rabbits with respiratory failure induced by airway instillation of albumin [0.03%]
富 Dex 外源性肺表面活性物质治疗新生兔气管内注射白蛋白所致呼吸衰竭的疗效研究
A Calkovska,M Some,B Linderholm et al.
A Calkovska et al.
The aim of the study was to investigate lung function and morphology in newborn rabbits with acute respiratory failure induced by airway instillation of albumin and to test whether the therapeutic effect of exogenous modified natural surfac...
Bronchodilating effect of combined therapy with ipratropium bromide and ondansetron in patients with COPD [0.03%]
溴化异丙托溴铵联合昂丹司琼治疗慢性阻塞性肺疾病患者支气管舒张效果
Romain Pauwels,Guy F Joos,Charles Fogarty et al.
Romain Pauwels et al.
The objectives of this study were to determine the effect of single and repeat dosing with oral ondansetron, a 5-HT3-specific receptor blocker, on the degree and duration of bronchodilation induced by inhaled ipratropium bromide in patients...
Agreement between two methods for assessing bioequivalence of inhaled salbutamol [0.03%]
评定沙丁胺醇吸入生物等效性的两种方法的一致性分析
Federico Lavorini,Pietro Geri,Gianna Camiciottoli et al.
Federico Lavorini et al.
For inhaled medications, bioequivalence testing is becoming increasingly important owing to the availability of many inhalation devices. We evaluated agreement between the Finney bioassay and the Emax model in the assessment of bioequivalen...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(2):380-4. DOI:10.1016/j.pupt.2007.10.001 2008
The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo [0.03%]
一种新型内质网钙通道阻断剂YM-58483/BTP-2的体内外抗炎作用及其机制研究
Keiko Ohga,Ryuichi Takezawa,Taiji Yoshino et al.
Keiko Ohga et al.
YM-58483/BTP-2, 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, blocks the store-operated Ca2+ entry (SOCE) that mediates the activation of non-excitable cells. This study investigated the pharmacol...
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17 [0.03%]
粗糙限制曲霉A-17菌株蛋白质组分致敏引起的特应性类似咳嗽过敏反应模型
Junzo Kamei,Yoshiki Takahashi,Takeshi Itabashi et al.
Junzo Kamei et al.
We examined the sensitivity of the cough reflex to inhaled citric acid in guinea pigs that had been actively sensitized with the protein fraction of Aspergillus restrictus strain A-17. The number of coughs elicited by an aerosol of 5% citri...
Do airway clearance mechanisms influence the local and systemic effects of inhaled corticosteroids? [0.03%]
气道清除机制会影响吸入性皮质类固醇的局部和全身作用吗？
Staffan Edsbäcker,Per Wollmer,Olof Selroos et al.
Staffan Edsbäcker et al.
The role of airway clearance in inhaled drug therapy is complex. Disease-induced bronchoconstriction results in a central drug-deposition pattern where mucociliary clearance is most efficient. When drug-induced bronchodilation is achieved, ...
Prenatal exposure to endotoxin in rats attenuates the allergic airways eosinophil infiltration in the adult offspring: role of inducible nitric oxide synthase activation [0.03%]
孕鼠体内内毒素暴露削弱子代成年期过敏性呼吸道嗜酸性粒细胞浸润：诱导型一氧化氮合酶活化的角色作用
Fernanda Datti,Marcelo Datti,Edson Antunes
Fernanda Datti
A correlation between stressful events experienced by the mother during pregnancy and progression of respiratory disease in descendants has been reported. Prenatal exposure to lipopolyssacharide (LPS) reduces allergic airway inflammation in...
Sarahn M Wheeler,Jacquelynne P Corey
Sarahn M Wheeler
Upper airway obstruction is a common clinical problem. Nasal obstruction can be the result of nasal anatomy, mucosal swelling, or acquired blockage. The anatomy of the upper airway differs from the lower because of the presence of erectile ...