Evaluation of Plasma Polyethylene Glycol (PEG) Levels in a Healthy Adult Population [0.03%]
评估健康成人中血浆聚乙二醇(PEG)水平
Klaus Kubesch,Christian Lubich,Daniel Mascher et al.
Klaus Kubesch et al.
Polyethylene glycols (PEGs) are amphiphilic polymers that are used extensively in consumer products and PEGylated biotherapeutics. Although PEGs are considered biologically inert with a low toxicity, anti-PEG antibodies have been detected i...
A 1-Month Exploratory Combination Safety and Toxicity Study of Co-Administration of Sitagliptin and Telmisartan in Male Wistar Han Rats [0.03%]
马来地特坦和西格列汀联合给药的1个月探索性安全性和毒性研究（Wistar大鼠）
Chitrang R Shah,Sandip B Patel,Vishal J Patel et al.
Chitrang R Shah et al.
Diabetes and hypertension often coexist and need complex pharmacological management. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is widely used for glycemic control, and telmisartan, an angiotensin II receptor blocker, is the preferred...
A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae [0.03%]
Anaerostipes caccae全面毒理学安全评价
Vickie Modica,Róbert Glávits,Amy Clewell et al.
Vickie Modica et al.
Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple homeostati...
Mitochondria: Key Mediator for Environmental Toxicant-Induced Neurodegeneration [0.03%]
线粒体在环境毒物诱导的神经退行性疾病发生中的作用
Nishi Shah,Bhagawati Saxena,Richa Gupta
Nishi Shah
Compiling evidence strongly suggests the involvement of environmental toxicants, including heavy metals (aluminum, arsenic, lead, copper, cadmium, mercury, and manganese), pesticides, and solvents, as the prime culprits of neurodegenerative...
Preclinical Safety of APG777, A Novel Extended Half-Life Anti-Interleukin-13 Monoclonal Antibody, in Cynomolgus Monkeys [0.03%]
用于食蟹猴的新型长效抗白介素13单克隆抗体APG777的药代动力学和安全性研究
Daniel Rubio,Eric Zhu,Archie Thurston et al.
Daniel Rubio et al.
Interleukin-13 (IL-13) is a cytokine implicated in the pathophysiology of type 2 inflammatory diseases and is a clinically validated target in atopic dermatitis. APG777 is a humanized IgG1 monoclonal antibody with an optimized pharmacokinet...
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as Used in Cosmetics [0.03%]
作为化妆品组分的羟基四甲基哌啶氧化物和三(四氢甲基乙二胺)柠檬酸盐的安全性评估
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as used in cosmetic formulations. These ingredients are reported to function ...
Wilbur Johnson Jr,Wilma F Bergfeld,Donald V Belsito et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 9 vanilla-derived ingredients as used in cosmetics. These ingredients are reported to function mostly as skin conditioning agents in cosmetic products. Because f...
Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics [0.03%]
作为化妆品原料使用的乙酰六肽-8酰胺的安全性评估
Wilbur Johnson Jr,Wilma F Bergfeld,Donald V Belsito et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Acetyl Hexapeptide-8 Amide (synonymous with Acetyl Hexapeptide-8 (sans "Amide")) in cosmetic products; this ingredient is reported to function as a skin conditio...
Wilbur Johnson Jr,Wilma F Bergfeld,Donald V Belsito et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 5 titanium complexes as used in cosmetic products; these ingredients have the following reported functions in cosmetics: surface modifier (Isopropyl Titanium Tri...
Priya Cherian,Wilma F Bergfeld,Donald V Belsito et al.
Priya Cherian et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 7 honey-derived ingredients. All of these ingredients are reported to function in cosmetics as skin-conditioning agents. The Panel considered the available data ...