Genotoxicity and Repeat-Dose 28-day Oral Toxicological Evaluation of Sukré™, a Purified l-Arabinose From Acacia Hydrolysate [0.03%]
苏克雷(Sukré?)的基因毒性和重复给药28天口服毒理学评价研究报告：来自刺槐糖液的L-阿拉伯糖纯品
Margitta Dziwenka,Katrina V Emmel
Margitta Dziwenka
Sukré™, a highly purified l-arabinose produced from hydrolyzed acacia, has potential uses as a natural sweetener. To evaluate the safety of l-arabinose, a battery of GLP-compliant in vitro and in vivo studies were conducted with Sukré™ ...
Safety Assessment of Equisetum arvense-Derived Ingredients as Used in Cosmetics [0.03%]
化妆品中使用的大巢蕨植物原料的安全评估报告
Wilbur Johnson,Wilma F Bergfeld,Donald V Belsito et al.
Wilbur Johnson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of five Equisetum arvense-derived ingredients as used in cosmetic products; all of these ingredients are reported to function as skin-conditioning agents in cosmeti...
Incidence of Spontaneous and Urethane-Induced Tumors in a 26-Week Carcinogenicity Study in Tg.rasH2 Mice Sourced From CLEA, Japan [0.03%]
日本CLEA公司供应的Tg.rasH2小鼠26周致癌性试验中自发性和尿烷诱导肿瘤发生率
Madhav Paranjpe,Amod Kale,Narendra Deshmukh et al.
Madhav Paranjpe et al.
The Tg.rasH2 mouse is a validated bioassay system for evaluation of carcinogenic potential, and it is confirmed to be sensitive to both genotoxic and nongenotoxic carcinogens. This is also one of the models specified in ICH S1B Guidance, en...
Incidence of Neoplasms and Selected Non-Neoplastic Findings in Control and Positive Control Groups in CByB6F1-Tg(HRAS)2Jic Hemizygous (rasH2TM) Mouse Carcinogenicity Studies [0.03%]
CByB6F1-Tg(HRAS)2Jic半合子（rasH2TM）小鼠致癌性研究中，对照组和阳性对照组肿瘤及选择的非肿瘤发现的发病率
Mark A Morse,Kimberly L Bonnette,Timothy W Carlson et al.
Mark A Morse et al.
The rasH2TM mouse model has become the primary alternative to a 2-year mouse carcinogenicity study in safety testing of human pharmaceuticals. In this publication, we present the neoplastic incidence for 2291 control males, 2191 control fem...
Direct Comparison of the Impacts of Bisphenol A, Bisphenol F, and Bisphenol S in a Male Rat 28-Day Oral Exposure Study [0.03%]
比较双酚A、双酚F和双酚S在为期28天的大鼠口服暴露试验中的影响差异研究
Guillaume Pelletier,Gen Sheng Wang,Adam Wawrzynczak et al.
Guillaume Pelletier et al.
Although Bisphenol A (BPA) is still used in consumer products, concerns about its toxicity led to the adoption of structurally related replacement products such as Bisphenol F (BPF) and Bisphenol S (BPS). Unfortunately, comparing the biolog...
Methylglyoxal Aggregates α-Synuclein by Inhibiting SIRT1-Hif-1α in Intestinal Enteroendocrine Cells [0.03%]
甲基乙二醛通过抑制肠内分泌细胞中的SIRT1-Hif-1α聚集α-突触核蛋白
Eugene Huh,Jin Myeong Kim,Seong Hye Kim et al.
Eugene Huh et al.
Parkinson's disease (PD) is characterized by the abnormal aggregation of α-synuclein, which can originate in the gut and propagate to the brain. Recent evidence suggests a correlation between metabolic disorders, particularly diabetes, and...
Xianglong Wang,Yushan Tian,Xiao Li et al.
Xianglong Wang et al.
Traditional tobacco products are harmful to the body, especially the respiratory system. In recent years, different kinds of novel and emerging nicotine and tobacco products have emerged on the market and are becoming increasingly popular w...
Re-Review Summary of Ricinus Communis (Castor) Seed Oil and Ricinoleates as Used in Cosmetics [0.03%]
cosmetics技术评审总结-假亚麻子( castor )油及蓖麻酸盐用作化妆品中的成分
Monice M Fiume,Wilma F Bergfeld,Donald V Belsito et al.
Monice M Fiume et al.
This is a safety assessment of Ricinus Communis (Castor) Seed Oil and various ricinoleate ingredients as used in cosmetics. These ingredients are reported to function primarily as skin-conditioning agents, emulsion stabilizers, and surfacta...
Safety Assessment of Levulinic Acid and Sodium Levulinate as Used in Cosmetics [0.03%]
cosmetics中使用的丙二酸和钠盐的安全评估报告总结公示
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Levulinic Acid and Sodium Levulinate as used in cosmetic formulations. These ingredients are both reported to function in cosmetics as skin conditioning agents, ...
Priya Ferguson,Wilma F Bergfeld,Donald V Belsito et al.
Priya Ferguson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Diacetone Alcohol as used in cosmetic formulations. This ingredient is reported to function as a fragrance ingredient and solvent. The Panel considered the avail...