Amended Safety Assessment of Salicylic Acid and Salicylates as Used in Cosmetics [0.03%]
化妆品中水杨酸及水杨酸盐的修订安全性评估报告中文标题：化妆品中水杨酸及水杨酸盐的修订安全性评估报告
Wilbur Johnson Jr,Jinqiu Zhu,Wilma F Bergfeld et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Salicylic Acid and 17 salicylates; 15 of these ingredients were previously reviewed by the Panel, and 3 are reviewed herein for the first time. Some of the repor...
FDA/CDER/OND Experience With New Approach Methodologies (NAMs) [0.03%]
美国食品药品监督管理局新 approach 方法学（NAMs）经验
Jia Yao,Jackye Peretz,Ilona Bebenek et al.
Jia Yao et al.
The U.S. Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), and Office of New Drugs (OND) has continuously encouraged the submission of nonclinical tests utilizing new approach methodologies (NAMs) and spons...
Inhalation of Particulate-free Diesel Engine Exhaust Induces Pulmonary Histopathological Alterations in Rat Models: Role of TRPV1 Receptors and Oxidative Stress During Sub-acute Exposure [0.03%]
无颗粒物的柴油机尾气吸入对大鼠肺部病理损伤的影响：瞬时受体电位香草素型1通道和氧化应激的作用机制
Ravindran Revand,Aditya Dontham,Swarnabha Sarkar et al.
Ravindran Revand et al.
Exposure to diesel exhaust air pollutants is a key environmental threat for pulmonary and cardiovascular diseases. Oxidative stress and Transient Receptor Potential Vanilloid-1 (TRPV1) receptors exhibit pivotal contributions in mediating lu...
Ozone Preexposure Exacerbates Septic Lung Injury Through ADAR1 Modulation and Pyroptosis Activation [0.03%]
臭氧预处理通过ADAR1调节和细胞焦亡活化加剧脓毒症肺损伤
Quanzhen Wang,Yajun Liu,Yuke Zhang et al.
Quanzhen Wang et al.
Chronic ozone exposure in urban environments compromises lung function, predisposing individuals to severe sepsis outcomes from common infections. Pyroptosis, a type of programmed cell death, is implicated in sepsis and lung injury, and its...
Differential Activation of Peroxisome Proliferator-Activated Receptor Alpha by Per- and Polyfluoroalkyl Substances [0.03%]
全氟和多氟烷基物质激活过氧化物酶体增殖激活受体α的差异性研究
Mary Helen Kanitz,Cynthia Striley
Mary Helen Kanitz
Per- and polyfluoroalkylated substances (PFAS) are persistent anthropogenic chemicals widely distributed in the environment that are known to have toxic effects in animals and humans following exposure. Some PFAS have been shown to activate...
Microplastics: A Narrative Review on Modes of Exposure and Impact on Human Health [0.03%]
微塑料：暴露途径和对人类健康影响的叙事性综述
Sandhya Jinesh,Rajan Radhakrishnan
Sandhya Jinesh
BackgroundPlastics have been widely used for several decades, but their persistence in the environment has resulted in the widespread presence of microplastics (MPs) in the air, water, and soil. With particle sizes smaller than 5 mm, MPs ar...
Two-Year Inhalation Studies in Mice and Rats With HFO-1234ze(E), a Near Zero Global Warming Potential Propellant for Use in Pressurized Metered Dose Inhalers [0.03%]
HFO-1234ze(E)两年吸入染毒研究（对经压力气雾剂递送的具有近零全球变暖潜能值推进剂的米仓鼠和大鼠吸入毒性研究）
Paul Giffen,Matthew Jacobsen,James Cartwright et al.
Paul Giffen et al.
HFO-1234ze(E) is being developed as a next-generation propellant (excipient), with near zero global warming potential, for use in pressurized metered dose inhalers. In accordance with regulatory guidance, an assessment of the carcinogenic p...
Inhibitory Effects and Characteristics of Byakangelicol on the Activity of Multiple Cytochrome P450 Isoforms [0.03%]
白 Angelicol对多种细胞色素P450同工酶活性的抑制作用及特征
Ting Lin,Xiao He,Pingfa Lin et al.
Ting Lin et al.
Byakangelicol, a furanocoumarin derived from Angelica dahurica, possesses anti-inflammatory and antitumor activities. Since cytochrome P450 2A6 (CYP2A6) is the major enzyme responsible for coumarin metabolism, it is important to evaluate th...
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 24 silicate ingredients that are solid inorganic oxides, comprising, in part, silicon dioxide, which can be derived from naturally occurring minerals or can be p...
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics [0.03%]
作为化妆品使用的谷氨酰胺二乙酸四钠和β-丙氨酸二乙酸盐的安全性评估报告
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid, which are reported to function as chelating agents in cosmetic products. The Panel reviewed the a...