Safety Assessment of Salvia officinalis (Sage)-Derived Ingredients as Used in Cosmetics [0.03%]
药用鼠尾草化妆品原料的安全评估
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 12 Salvia officinalis (Sage)-derived ingredients as used in cosmetic formulations. These ingredients are most commonly reported to function as skin conditioning ...
Safety Assessment of Zingiber officinale (Ginger) - Derived Ingredients as Used in Cosmetics [0.03%]
化妆品中源自姜(Zingiber officinale)成分的安全评估
Priya Ferguson,Wilma F Bergfeld,Donald V Belsito et al.
Priya Ferguson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 9 Zingiber officinale (ginger)-derived ingredients. The majority of these ingredients are reported to function in cosmetics as skin-conditioning agents. The Pane...
Wilbur Johnson Jr,Regina Tucker,Wilma F Bergfeld et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 4 starch phosphates as used in cosmetic formulations. Distarch Phosphate is reported to function in cosmetics as an anticaking agent and binder. Distarch Phospha...
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 16 barley-derived ingredients, most of which are reported to function as skin-conditioning agents in cosmetic products. Industry should continue to use good manu...
Priya Ferguson,Wilma F Bergfeld,Donald V Belsito et al.
Priya Ferguson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Acetyl Glucosamine, Glucosamine, Glucosamine HCl, and Glucosamine Sulfate. Two of the ingredients, Acetyl Glucosamine and Glucosamine Sulfate, are reported to fu...
Pair-Feeding Differentiates Feed-Dependent and Pharmacodynamic Effects of Telmisartan in Wistar Rats [0.03%]
配对喂养法在Wistar大鼠中区分氯沙坦的营养依赖性和药理动力学效应
Chitrang R Shah,Sandip B Patel,Vishal J Patel et al.
Chitrang R Shah et al.
Telmisartan, an angiotensin II receptor blocker with partial PPAR-γ agonist activity, exhibits pleiotropic effects beyond its antihypertensive action, including modulation of lipid metabolism, erythropoiesis, and renal function. However, i...
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 8 fatty ethers as used in cosmetic formulations. These ingredients are reported to function in cosmetics as skin conditioning agents. The Panel reviewed the avai...
5-Methoxy-N,N-Dimethyltryptamine: Functional Safety Pharmacology and Video-EEG Assessment of a Short-Acting Serotonergic Psychedelic in Beagle Canines [0.03%]
5-甲氧基-N,N-二甲基色胺：一项于比格犬的短期作用血清素致幻剂的功能安全药理学及视频脑电图评估研究
Amir Lotfi,Samantha Sparapani,Mylene Pouliot et al.
Amir Lotfi et al.
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a serotonin receptor agonist, in clinical development for the treatment of major depression and other psychiatric disorders. A critical safety concern for serotonergic compounds is their poten...
An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics [0.03%]
ICH S13 指南中寡核苷酸药物非临床安全性评价的关键考虑因素之行业观点
Jennifer D Sisler,Patrik Andersson,Alan Brown et al.
Jennifer D Sisler et al.
Oligonucleotide therapeutics (ONTs) are a growing class of nucleic acid-based therapies with the potential to treat a variety of diseases through several different mechanisms of action (MoA). The most prevalent MoA entails the inhibition of...