Hitching a Ride to Overcome Barriers: Nonclinical Safety Considerations for Bioconjugated Oligonucleotides [0.03%]
利用载体优势克服递送障碍：关于生物偶联寡核苷酸的非临床安全问题考虑
Sheroy Minocherhomji,Katie Sokolowski,Kelle Franklin et al.
Sheroy Minocherhomji et al.
Advances in the delivery and safety of nucleic acid-based therapeutics are enabling tissue-selective targeting and broadening the reach of genetic medicines. In addition to GalNAc-conjugated oligonucleotides, newer modalities-predominantly ...
Editor's note [0.03%]
编者按
Mary Beth Genter
Mary Beth Genter
Safety Evaluation of Intranasal Nalmefene in Juvenile Rat Studies in Support of Clinical Trials in Pediatric Patients From Birth to 12 Years of Age [0.03%]
支持儿科临床试验的鼻用纳美芬 juvenile 大鼠研究的安全评估（出生至12岁）
Vick Kostrubsky,Frank Gray,Elise M Lewis et al.
Vick Kostrubsky et al.
Nalmefene is an opioid antagonist used in OPVEE® nasal spray approved for use in patients 12 years of age and older. To support future clinical studies in younger pediatric populations, 2 GLP juvenile rat studies were conducted to assess t...
Investigating the Impact of Bisphenol A on Gastric Cancer Through Network Toxicology and Molecular Docking [0.03%]
网络毒理学和分子对接在双酚A促进胃癌作用研究中的应用探讨
Wen-Yan Yu,Yue Zhang
Wen-Yan Yu
The extensive application of bisphenol A (BPA), an endocrine-disrupting substance in polymer-based products and consumer commodities, has sparked concerns over its carcinogenic potential. However, the molecular mechanisms underlying BPA-ind...
Pre-clinical Safety Assessment of Quercetagetin: Insights From Repeated-Dose Toxicity and Genotoxicity Studies [0.03%]
异鼠李素的临床前安全性评估：重复给药毒理学和遗传毒性研究的见解
Abhijith Subrahmanya,Sripathy Ravichandran,Surya Narayan Naick M et al.
Abhijith Subrahmanya et al.
Quercetagetin (QG) is a naturally occurring flavonoid found in marigold (Tagetes erecta). It has garnered attention for its potential to support immune health, regulate blood sugar levels, and enhance metabolism. Yet, unlike the closely rel...
Advanced Glycation End Products Induce Cuproptosis and Then Promote the Activation and Migration of Cardiac Fibroblasts [0.03%]
advanced glycation end products诱导铜死亡并促进心脏纤维母细胞的活化和迁移
Jian Xiao,Zan-Hua Shi,Xin-Hua Ma et al.
Jian Xiao et al.
Excessive advanced glycation end products (AGEs) can lead to cardiovascular diseases such as myocardial fibrosis (MF). Although studies have found that AGEs induce cuproptosis, and cuproptosis promotes fibrosis, it has not been confirmed wh...
Sub-Cytotoxic Mitochondrial Stress in Cardiomyocytes and Whole-Organism Toxicity in C. elegans Induced by Molnupiravir [0.03%]
molnupiravir诱导的心肌细胞亚毒性线粒体应激及C.elegans全身生物毒性
Zehra Keskin,Ebru Didem Kuran,Meltem Gulec et al.
Zehra Keskin et al.
Many antiviral agents are known to induce off-target mitochondrial toxicity due to the prokaryotic origin of mitochondria. Mitochondrial dysfunction is frequently linked to cardiotoxicity. We aimed to elucidate the mitochondrial toxicity pr...
Safety Assessment of Dodecanedioic Acid (Dodecanedioic Acid Disodium Salt) Using Genotoxicity and Repeated 28-day Oral Toxicological Evaluation [0.03%]
用致突变性和重复28天经口毒性评价评估十二烷二酸(十二烷二酸二钠盐)的安全性
Deepali Sharma,Mangi Lal Choudhary,Pragati Bawankar et al.
Deepali Sharma et al.
To evaluate the safety of Metabolyte™ (sodium dodecanedioate) for human consumption, results from in vitro and in vivo studies are reported, including a bacterial reverse mutation assay, an in vitro mammalian chromosome aberration test, an...