Safety Assessment of Radish Root - Derived Ingredients as Used in Cosmetics [0.03%]
化妆品中用于化妆品的萝卜根衍生成分的安全评估
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 7 radish root-derived ingredients, most of which are reported to function as hair and skin conditioning agents in cosmetic products. Because final product formul...
Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity [0.03%]
醛糖还原酶抑制剂埃帕他司汀通过补体依赖性细胞毒性抑制结直肠癌细胞增殖
Dongxu Peng,Zhengsheng Yi,Yidan Chen et al.
Dongxu Peng et al.
Complement-dependent cytotoxicity (CDC) is critical for tumor cell proliferation. Previous work has revealed that epalrestat (EPA), an inhibitor of aldose reductase, plays a crucial role in tumor cell proliferation. However, whether CDC is ...
Nonclinical Safety Profiles of mRNA Therapeutics Comprising Unmodified or N1-Methyl-Pseudouridine-Modified Nucleosides Are Similar Following Repeated Administration [0.03%]
未甲基化或N1-甲基假尿苷修饰的mRNA药物反复给药后的非临床安全性档案相似
Albena Draycheva,Joske Millecam,Ebru Caba
Albena Draycheva
mRNA, either with unmodified or modified nucleosides, has become an important modality in medicines and vaccines. Despite the inclusion of N1-methyl-pseudouridine (N1mѰ)-modified mRNA in approved coronavirus 2019 (COVID-19) vaccines and th...
Amended Safety Assessment of Naturally-Sourced Clays as Used in Cosmetics [0.03%]
化妆品中天然来源粘土的安全再评估报告摘要
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Safety (Panel) assessed the safety of 8 naturally-sourced clay ingredients, of which 6 were previously reviewed, as used in cosmetic formulations. All of these ingredients are reported to function in cosmetics ...
Evaluation of the in vitro Toxicity of Novel Oxime Acetylcholinesterase Reactivators [0.03%]
几种新型肟类乙酰胆碱酯酶再活化剂的体外毒性评价研究
Janice E Chambers
Janice E Chambers
War and terrorism demonstrate the need for an improved antidote against nerve agents that cause brain damage following inhibition of acetylcholinesterase (AChE). Our laboratories invented substituted phenoxyalkyl pyridinium oxime AChE react...
Comparative in vitro Metabolism of Siamenoside I and Monk Fruit Extract [0.03%]
罗汉果提取物和 siamenoside i 的体外代谢比较研究
Ashley Roberts,Canaan Lam,Jennifer L G van de Ligt et al.
Ashley Roberts et al.
Siamenoside I, a cucurbitane glycoside 300 times sweeter than sucrose, is found in monk fruit (Siraitia grosvenorii). The triterpene glycosides in monk fruit, such as mogroside V, siamenoside I, and mogroside III, comprise around 1% of the ...
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Diatomaceous Earth as used in cosmetic formulations. It is reported to function as an abrasive, absorbent, anticaking agent, bulking agent, and opacifying agent ...
Priya Ferguson,Wilma F Bergfeld,Donald V Belsito et al.
Priya Ferguson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 glycolactone ingredients. Glucoheptonolactone and Gluconolactone are reported to function in cosmetics as skin-conditioning agents-miscellaneous, and Gluconola...
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Basic Yellow 87, which is reported to function as a hair dye in cosmetic products. The Panel reviewed the available data to determine the safety of this ingredie...
The Comparative Sensitivity to Ketamine-Induced Neuronal Death in Juvenile and Adult Rats [0.03%]
氯胺酮诱导的大鼠海马神经元凋亡的年龄差异性研究
Sumit Sarkar,Gonçalo Gamboa da Costa,Kellie Woodling et al.
Sumit Sarkar et al.
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, was first approved by the US FDA as KETALAR® for induction and maintenance of general anesthesia. Ketamine has been used off-label for depression treatment, while its S-enantiom...