Toxicity profile of solvents by aspiration approach for topical agent delivery to respiratory tract epithelium [0.03%]
吸入溶剂给药至呼吸道上皮的毒性特征研究
Sheela Sharma,Jin Lee,Pu Gao et al.
Sheela Sharma et al.
Agent solubility is a problem for aspiration of agents into lungs for chemopreventive efficacy evaluation, since many agents have to be dissolved in solvents. These solvents may be toxic to the lung epithelium. A study was conducted in fema...
A three-stage-integrative approach for the identification of potential hepatotoxic compounds from botanical products [0.03%]
一种用于识别草药产品潜在肝毒性化合物的三阶段综合方法
Yecheng Jin,Xiaoping Zhao,Yufeng Zhang et al.
Yecheng Jin et al.
With the increasing use of herbal medicines and dietary supplements, intensive concerns about their potential toxicities have been raised. Screening and identifying the toxic compounds from these botanical products composed by hundreds of c...
Repeat-dose toxicology evaluation in cynomolgus monkeys of AVI-4658, a phosphorodiamidate morpholino oligomer (PMO) drug for the treatment of duchenne muscular dystrophy [0.03%]
用于治疗杜氏肌营养不良的AVI-4658（PMO药物）在 cynomolgus猴体内的重复给药毒性评估
Peter Sazani,Kirk P Van Ness,Doreen L Weller et al.
Peter Sazani et al.
AVI-4658 is a phosphorodiamidate morpholino oligomer (PMO) drug designed to restore dystrophin expression in a subset of patients with Duchenne muscular dystrophy (DMD). Previous reports demonstrated this clinical proof-of-principle in pati...
Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice [0.03%]
评估外显子跳过磷吗啉吗啉寡聚物的化学和机制毒理学：/mdx小鼠模型中的研究
Peter Sazani,Kirk P Van Ness,Doreen L Weller et al.
Peter Sazani et al.
AVI-4658 is a phosphorodiamidate morpholino oligomer (PMO) designed to induce skipping of dystrophin exon 51 and restore its expression in patients with Duchenne muscular dystrophy (DMD). Preclinically, restoration of dystrophin in the dyst...
In vitro cytotoxic evaluation of processed natural coral in human osteoblasts [0.03%]
人成骨细胞中的人工制备天然珊瑚的体外毒性评估
Nor Shamsuria Omar,Thirumulu Ponnuraj Kannan,Abdul Rashid Ismail et al.
Nor Shamsuria Omar et al.
This study aimed to evaluate the in vitro cytotoxic effects of locally produced processed natural coral (PNC) using human osteoblasts (HOS). Cytotoxicity was not observed when HOS cells were cultured with PNC, as assessed by (3-(4,5-dimethy...
Photocytotoxicity of hypocrellin B (HB) was enhanced by liposomalization in vitro [0.03%]
抑霉唑B的光细胞毒作用在体外通过脂质体制剂进行增强
Zhixiang Zhou,Lina Zhang,Huimin Liu et al.
Zhixiang Zhou et al.
Hypocrellin B (HB) was encapsulated into a phosphatidylcholine liposome. Encapsulation of HB into liposomes not only improved the delivery of this photosensitizer but also increased its photodynamic efficacy compared to free HB molecules. L...
Comparative Study
International journal of toxicology. 2011 Mar;30(2):174-80. DOI:10.1177/1091581810394548 2011
Acute changes in pulmonary function following microinstillation inhalation exposure to soman in nonatropenized guinea pigs [0.03%]
未用阿托品处理的 Guinea 猪经气管微量吸入沙林后的肺功能急性变化
Michael W Perkins,Zdenka Pierre,Peter Rezk et al.
Michael W Perkins et al.
Barometric whole-body plethysmography (WBP) was used to examine pulmonary functions at 4 and 24 hours postexposure to soman (GD) in guinea pigs without therapeutics to improve survival. Endotracheal aerosolization by microinstillation was u...
Cardiovascular function in nonclinical drug safety assessment: current issues and opportunities [0.03%]
非临床药物安全性评价中的心血管功能评估：当前问题与机遇
R Dustan Sarazan,Scott Mittelstadt,Brian Guth et al.
R Dustan Sarazan et al.
There are several recent examples where clinically significant, safety-related, drug effects on hemodynamics or cardiac function were not apparent until large clinical trials were completed or the drugs entered the consumer market. Such lat...
Effects of anesthetics and terminal procedures on biochemical and hormonal measurements in polychlorinated biphenyl treated rats [0.03%]
麻醉剂和终端处理对多氯联苯致大鼠生化和激素测定的影响
Daniel Desaulniers,Al Yagminas,Ih Chu et al.
Daniel Desaulniers et al.
This investigation reports the effects of various terminal procedures, and how they modified the responses to a toxicant (polychlorinated biphenyls [A1254], 130 mg/kg/day × 5 days) administered by gavage to Sprague-Dawley male rats. Termin...
A 30-day preclinical safety evaluation study of recombinant human follicle-stimulating hormone in female rhesus monkeys [0.03%]
重组人促卵泡激素在雌性食蟹猴30天预临床安全评估研究
Yongming Cai,Zhengmin Chen,Zongpeng Zhang et al.
Yongming Cai et al.
The objective of this study was to identify potential target organs for toxicity of recombinant human follicle stimulating hormone (r-hFSH) in female rhesus monkeys and to establish a no observed adverse effect level (NOAEL). In all, 24 fem...