Alice Akinsulie,Preethi S Raj,Wilma F Bergfeld et al.
Alice Akinsulie et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 8 glycerin ethoxylates, as used in cosmetic formulations. All of these ingredients are reported to function in cosmetics as skin-conditioning agents, and most ar...
Christina L Burnett,Wilma F Bergfeld,Donald V Belsito et al.
Christina L Burnett et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Basic Brown 17, which is reported to function as a hair dye in cosmetic products. The Panel reviewed the available data to determine the safety of this ingredien...
Monice M Fiume,Wilma F Bergfeld,Donald V Belsito et al.
Monice M Fiume et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurre...
Safety Assessment of Scutellaria baicalensis-Derived Ingredients as Used in Cosmetics [0.03%]
化妆品用汉黄芩属原料的安全评估研究进展
Wilbur Johnson Jr,Wilma F Bergfeld,Donald V Belsito et al.
Wilbur Johnson Jr et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 4 Scutellaria baicalensis-derived ingredients in cosmetic products; these ingredients are reported to have the following functions in cosmetics: antimicrobial ag...
Safety and Toxicological Evaluation of Subunit Keyhole Limpet Hemocyanin-Loaded Lipid-PLGA Hybrid Nanoparticles (sKLH-hNPs) as a Nanocarrier for an Opioid Use Disorder Vaccine [0.03%]
壳聚糖-脂质-PLGA杂化纳米颗粒(sKLH-hNPs)作为阿片类药物使用障碍疫苗的纳米载体的安全性和毒理学评估
Debra Walter,Qiaoqiao Ci,He Hu et al.
Debra Walter et al.
A nanoparticle-based immunization strategy offers a promising treatment for opioid use disorder (OUD). This study tested the in vivo safety of subunit keyhole limpet hemocyanin-loaded lipid-PLGA hybrid nanoparticles (sKLH-hNPs) as a nanocar...
Evaluation of Repeat Dose Toxicity and Embryo-Fetal Developmental Toxicity of Novel Glucokinase Activator ZYGK1 in Wistar Rats [0.03%]
新型葡萄糖激酶激活剂ZYGK1重复给药毒性及妊娠 rat-胎发育毒性评价研究报告
Kalpesh Patani,Sudhir Patel,Amit Joharapurkar et al.
Kalpesh Patani et al.
ZYGK1 is a novel small molecule glucokinase (GK) activator. The purpose of this study was to assess the repeated dose toxicity of ZYGK1 in male and female Wistar rats and its effect on pregnancy and embryo-fetal development in pregnant fema...
Predictive Modeling of Pharmacokinetic Drug-Drug and Herb-Drug Interactions in Oncology: Insights From PBPK Studies [0.03%]
基于PBPK研究的肿瘤学药代动力学药物相互作用和中西药相互作用的预测模型及其启示
Enes Emre Taş,Kutlu O Ulgen
Enes Emre Taş
Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to anticipate, quantify, and strategically manage drug-drug (DDI) and herb-drug (HDI) interactions that can alter the exposure of chemotherapy agents together with c...
A Comparison of Spontaneous Tumor Incidence in Charles River Sprague Dawley Rats and Wistar Hannover Rats [0.03%]
威斯tparameter瀚汉诺威 rats与查尔斯河Sprague Dawley大鼠自发性肿瘤发生率的比较
Mark A Morse,Christopher N Papagiannis,Donald G Stump et al.
Mark A Morse et al.
The Crl:CD(SD) Sprague Dawley rat and the Crl:WI(Han) Wistar Hannover (Wistar Han) rat are two outbred rat models commonly used in 2-year carcinogenicity testing. In this presentation, the spontaneous incidences of common, rare, and fatal n...
Nonclinical Safety Evaluation of 2-Deoxy-D-Glucose Following Twice-Daily Oral Administration for 28 Days in Beagle Dogs [0.03%]
2-脱氧-D-葡萄糖非临床安全性评价双倍日剂量口服给药28天比格犬毒性研究
Rahul M Nandre,Pramod S Joshi,Thomas P Sutula et al.
Rahul M Nandre et al.
2-Deoxy-D-Glucose (2-DG) has anticonvulsant and antiseizure effects in rodent models and is in the development phase for novel antiseizure treatment. To evaluate potential toxicity, Beagle dogs (five/sex/group) were orally gavaged with eith...
Effects of Solvent Dimethyl Sulfoxide Invites a Rethink of Its Application in Amyloid Beta Cytotoxicity [0.03%]
溶剂二甲亚砜会促使人们对淀粉样蛋白β毒性的应用产生新的思考吗？
Yanhong Fu,Jiafa Zhang,Canhong Yang et al.
Yanhong Fu et al.
Dimethyl sulfoxide (DMSO) is commonly used as a solvent for preparing amyloid-beta (Aβ) peptides implicated in Alzheimer's disease. While considered relatively non-toxic at low concentrations, DMSO itself may exert biological effects that ...