Crawling into the Unknown: Unveiling Novel Psychoactive Substances (NPSs) in the Post Pandemic Era Utilizing the NPS finder® [0.03%]
爬出未知：利用NPS finder®揭露疫情后新型精神活性物质(NPSs)的新方法
Elena Deligianni,Alessandro Vento,Georgios Papazisis et al.
Elena Deligianni et al.
Novel Psychoactive Substances (NPSs) and other psychoactive or misuse-relevant compounds present a persistent global public health threat, underscoring the critical need for real-time crawling and monitoring tools to investigate and provide...
Structure-Dependent Cytotoxicity of Environmentally Relevant Benzothiazole Derivatives Across Human Cell Models [0.03%]
结构依赖的人类细胞模型的苯并噻唑衍生物 cytotoxicity 研究
Stephanie Wolfe,Tasniyah Nayaz,Alisha Janiga-MacNelly et al.
Stephanie Wolfe et al.
Benzothiazoles are widely used rubber additives and common contaminants in urban runoff, yet their toxicity across human tissues remains poorly characterized. We evaluated the cytotoxicity of six benzothiazole derivatives, benzothiazole (BT...
Regulatory Case Studies Encountered by Project Toxicologists in Drug Development [0.03%]
药物研发过程中项目毒理学家遇到的监管案例分析
Katie Sokolowski,Simon Authier,Denis Roy et al.
Katie Sokolowski et al.
Today, toxicologists have a diverse role in drug development and function in multidisciplinary teams with unique expertise. This article summarizes presentations from a continuing education (CE) course at the 2024 Annual Meeting of the Amer...
Subchronic Oral Toxicity and Genotoxicity Assessment of SCFA 455, a Clostridium butyricum S-45-5 Culture Filtrate Powder [0.03%]
芽孢杆菌S-45-5菌体滤过粉亚慢性经口毒性及遗传毒性试验
Se Bin Kim,Do Young Hwang,Seong-Jeong Han
Se Bin Kim
Short-chain fatty acids (SCFAs) support intestinal homeostasis and have been explored for applications in functional foods. SCFA 455 is an SCFA-enriched culture filtrate powder produced from Clostridium butyricum S-45-5. This study evaluate...
Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics [0.03%]
用于化妆品的褐藻提取物作为新原料的安全性评估
Priya Ferguson,Lillian Becker,Wilma F Bergfeld et al.
Priya Ferguson et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of brown algae-derived ingredients; 82 brown algae-derived ingredients were found in the in the International Cosmetic Ingredient Dictionary (Dictionary), however, ...
Safety Assessment of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as Used in Cosmetics [0.03%]
cosmetics用聚羟基硬脂酸、聚3-羟基辛酸和聚乳酸的安全性评估
Preethi S Raj,Wilma F Bergfeld,Donald V Belsito et al.
Preethi S Raj et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as used in cosmetic formulations. These ingredients are reported to function in cosmet...
Assay-dependent Artifactual Prolongation of Activated Partial Thromboplastin Time (aPTT) in Cynomolgus Monkeys: Potential Role of POEGMA [0.03%]
食蟹猴活化部分凝血活酶时间（APTT）的假延长：POEGMA的潜在作用
Gregory W de Hart,Katsu Ishida,Ryan Boyer et al.
Gregory W de Hart et al.
We identified an assay-dependent, artifactual prolongation of activated partial thromboplastin time (aPTT) during nonclinical safety studies of an enzyme biologic conjugated with a next-generation polyethylene glycol (PEG)-like stealth poly...
Acute and Chronic Toxicity Assessment of Diosgenin Polyethylene Glycol Succinate in Wistar Rats: Safety Evaluation of a Novel Universal Solubilizer [0.03%]
菝葜皂苷元聚乙二醇化琥珀酸酯急性亚慢性毒性研究及安全性评估
Varsha Velmurugan,Velmurugan Shanmugham,Thangamani Arumugam
Varsha Velmurugan
Diosgenin, derived from Dioscorea alata, is a well-known traditional medicinal compound with therapeutic potential against various conditions, including cancer and cardiovascular diseases. This study aimed to synthesize diosgenin polyethyle...
Drug-Related Brain Vacuolation as an Unusual Presentation of Neurotoxicity in Sprague Dawley Rats [0.03%]
药物引起的脑室管性病变作为Sprague Dawley大鼠神经毒性的特殊表现形式
Bhanu P Singh,Megan R Wilichinsky,Kathryn E Bowenkamp et al.
Bhanu P Singh et al.
In a 4-week rat study, a nucleotide prodrug antiviral agent containing a synthetic non-natural amino acid (C-331) induced a dose-related vacuolation in the brain's white matter tracts without concurrent neuronal loss, gliosis, or neurologic...
Safety Assessment of Melaleuca alternifolia (Tea Tree)-Derived Ingredients as Used in Cosmetics [0.03%]
化妆品中使用的茶树（Melaleuca alternifolia）衍生成分的安全评估
Monice M Fiume,Wilma F Bergfeld,Donald V Belsito et al.
Monice M Fiume et al.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 8 Melaleuca alternifolia (tea tree)-derived ingredients as used in cosmetic formulations; 5 of these ingredients are reported to function in cosmetics as skin-co...