Critical role of hydrogen sulfide in the management of neurodegenerative disease [0.03%]
氢硫化物在神经退行性疾病管理中的关键作用
Rajashree Pawar,Dheeraj Pandey,Saba Naqvi et al.
Rajashree Pawar et al.
Hydrogen sulfide has been known to humans for about 300 years and the previous studies emphasize only on its toxic side effects. In the last two decennium, researchers have varied their perspectives and insights towards H2S biology based on...
Haoqi Li,Zijie Cheng,Dan Wu et al.
Haoqi Li et al.
Nitric oxide (NO) has been highlighted as an important factor in cardiovascular system. As a signaling molecule in the cardiovascular system, NO can relax blood vessels, lower blood pressure, and prevent platelet aggregation. Mitochondria s...
Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of ERO1α and reduces neuronal death in secondary traumatic brain injury [0.03%]
增强S-亚硝基谷胱甘肽还原酶活性可降低ERO1α的S-亚硝基化并减轻继发性脑损伤中的神经元死亡
Guangjie Liu,Dengfeng Lu,Jie Wu et al.
Guangjie Liu et al.
Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders, along with high mortality and disability rates. Pathological conversion of excess nitric oxide (NO) to S-nitrosoglutathion (GSNO) after TBI leads t...
Investigation of the susceptibility of clinical infection loads to nitric oxide antibacterial treatment [0.03%]
一氧化氮抗菌治疗下临床感染菌量的变化趋势探究
Lori M Estes Bright,Arnab Mondal,Vicente Pinon et al.
Lori M Estes Bright et al.
The persistent infection of medical devices by opportunistic pathogens has led to the development of antimicrobial medical device polymers. Nitric oxide (NO) is an endogenous antimicrobial molecule that is released through the degradation o...
KLF4's role in regulating nitric oxide production and promoting microvascular formation following ischemic stroke [0.03%]
KLF4在缺血性卒中后调节一氧化氮产生和促进微血管形成中的作用
Kuo Li,Chuansuo Zhang,Li Xuan Wang et al.
Kuo Li et al.
This study examines KLF4's role in endothelial cells (ECs), emphasizing its effects on nitric oxide (NO) production, microvascular formation, and oxidative stress regulation following ischemic stroke. Through high-throughput sequencing, we ...
Exogenous sodium nitroprusside exhibits multiple positive roles in alleviating cadmium toxicity in tobacco (Nicotiana tabacum L.) [0.03%]
外源NaNO2在缓解镉毒害中的多重积极作用：以烟草（Nicotiana tabacum L.）为例
Kejin Song,Hongwei Li,Kunjian Yang et al.
Kejin Song et al.
As a donor of the gaseous signaling molecule nitric oxide (NO), sodium nitroprusside (SNP) has been shown to play a positive role in enhancing plant resistance to abiotic stress. However, its role in alleviating cadmium (Cd) toxicity in tob...
Downregulation of neuronal nitric oxide synthase (nNOS) within the paraventricular nucleus in Ins2Akita-type-1 diabetic mice contributes to sympatho-excitation [0.03%]
糖尿病鼠下视丘视上核神经元一氧化氮合成酶向下调节导致交感神经过度兴奋
Tapan A Patel,Lie Gao,Shane H Boomer et al.
Tapan A Patel et al.
Activation of both renin-angiotensin system (RAS) and the sympathetic system is the primary etiologic event in developing cardiovascular complications in diabetes mellitus (DM). However, the precise mechanisms for sympathetic activation in ...
Neurogenic-derived 6-nitrodopamine is the most potent endogenous modulator of the mouse urinary bladder relaxation [0.03%]
神经源性衍生的6-硝基多巴胺是小鼠膀胱松弛反应最强的内源性调节因子
Mariana Gonçalves de Oliveira,José Britto-Junior,Douglas Rafael Martins Dias et al.
Mariana Gonçalves de Oliveira et al.
6-Nitrodopamine (6-ND) modulates vas deferens, seminal vesicles, and corpus cavernosum contractility; however, its role on the lower urinary tract organs has not been evaluated. Investigations of isolated urinary bladders from wild-type (WT...
Generation and characterization of a conditional eNOS knock out mouse model for cell-specific reactivation of eNOS in gain-of-function studies [0.03%]
用于功能增益研究的条件型内皮一氧化氮合酶敲除小鼠系的建立及鉴定
Anthea LoBue,Zhixin Li,Sophia K Heuser et al.
Anthea LoBue et al.
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) in the vessel wall regulates blood pressure and cardiovascular hemodynamics. In this study, we generated conditional eNOS knock out (KO) mice characterized by a duplicat...
A systematic review and dose‒response meta-analysis of the association between nitrate & nitrite intake and gastroesophageal cancer risk [0.03%]
硝酸盐及亚硝酸盐摄入与消化道癌症风险的系统性综述和剂量效应meta分析
Mohammadreza Ghasemi,Mohammad Bahrami Koutenaei,Alireza Ghasemi et al.
Mohammadreza Ghasemi et al.
Objective: The objective of this systematic review and dose‒response meta-analysis was to assess the associations between the dietary consumption of nitrate and nitrite and the risk of gastric and esophageal cancer. ...