Real-Time Nitric Oxide Detection in Cytokine Stimulated Cancer Cells and Macrophages [0.03%]
细胞因子刺激的癌细胞和巨噬细胞中一氧化氮的实时检测
Jennifer Daw,Su Chung,Cheng-Yu Chen et al.
Jennifer Daw et al.
Inflammation is increasingly linked to disease progression, particularly in cancer, where elevated levels of inducible nitric oxide synthase (iNOS or NOS2), driven by tumor inflammation, is correlated with aggressive tumors and poor outcome...
Yu-Bo Shi,Lin Cheng,Yue Lyu et al.
Yu-Bo Shi et al.
Cancer metastasis is the leading cause of death in cancer patients, which renders heavy burdens to family and society. Cancer metastasis is a complicated process in which a large variety of biological molecules, cells and signaling pathways...
Mohamed Okda,Stefano Spina,Bijan Safaee Fakhr et al.
Mohamed Okda et al.
Nitric oxide (NO) is a versatile endogenous molecule with multiple physiological roles, including neurotransmission, vasodilation, and immune regulation. As part of the immune response, NO exerts antimicrobial effects by producing reactive ...
Microvessels-on-chip: Exploring endothelial cells and COVID-19 plasma interaction with nitric oxide metabolites [0.03%]
芯片上的微血管：探索内皮细胞和COVID-19血浆与一氧化氮代谢物的相互作用
Kanchana Pandian,Rudmer Postma,Anton Jan van Zonneveld et al.
Kanchana Pandian et al.
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily manifests as a flu-like illness with lung injury, often necessitating supplemental oxygen. Elderly individuals and those with pre-existing cardi...
The impact of ciliary length on the mechanical response of osteocytes to fluid shear stress [0.03%]
鞭毛长度对成骨细胞流体切应力力学响应的影响
Dong Ding,Ran Tian,Xiao Yang et al.
Dong Ding et al.
Background: Osteocytes are crucial for detecting mechanical stimuli and translating them into biochemical responses within the bone. The primary cilium, a cellular 'antenna,' plays a vital role in this process. However, t...
Rui Zhang,Wumei Shi,Xiaoyan Wu et al.
Rui Zhang et al.
As an endogenous gas signaling molecule, hydrogen sulfide (H2S) has been proved to have a variety of biological activities. Studies have shown that in some disease state H2S concentration in the body is lower than normal state. Based on the...
S-Denitrosylation counteracts local inflammation and improves survival in mice infected with K. pneumoniae [0.03%]
S-脱硝化对抗K.肺炎菌感染小鼠引起的局部炎症和改善生存率
Filipe Rodolfo Moreira Borges Oliveira,Thiele Osvaldt Rosales,Daiane Mara Bobermin et al.
Filipe Rodolfo Moreira Borges Oliveira et al.
Aim: Sepsis and septic shock remain are significant causes of mortality in the world. The inflammatory response should be at the basis of all organ dysfunction such as cardiovascular dysfunction, characterized by severe h...
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke [0.03%]
氢硫化物可减轻吸烟暴露大鼠胎盘血管内皮糖萼损伤并促进胎盘血管生成
Kexin Zhang,Geng Wu,Yonglan Chen et al.
Kexin Zhang et al.
Our previous study has shown that hydrogen sulfide (H2S) can attenuate cigarette smoke exposure (CSE)-induced placental injury in rats. This study investigated whether H2S alleviates CSE-induced endothelial glycocalyx (eGC) impairment and p...
The impact of mGlu2 or mGlu5 receptor activators on the production of l-arginine derivatives and the expression of PRMT5 or DDAH1 enzymes in animal models of cognitive decline [0.03%]
mGlu2或mGlu5受体激活剂对认知衰退模型动物L-精氨酸衍生物的生成及PRMT5或DDAH1酶表达的影响
Agata Płoska,Adrianna Radulska,Anna Siekierzycka et al.
Agata Płoska et al.
l-arginine derivatives (ADMA, SDMA, NMMA) are endogenous inhibitors of nitric oxide (NO֗) production, which is essential in critical brain processes including blood-brain barrier (BBB) integrity and long-term potentiation (LTP). ADMA and N...
The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: A systematic review and meta-analysis [0.03%]
一氧化氮合成酶3基因多态性与肺动脉高压发病风险的相关性：系统评价和meta分析
Kang Yi,Tao Guo,Wen-Xin Wang et al.
Kang Yi et al.
Background: We performed the present study to better elucidate the correlation of nitric oxide synthase 3 (NOS3) gene polymorphism with the risk of pulmonary arterial hypertension (PAH). ...