AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro [0.03%]
一种新型线粒体靶向供氢硫化合物AP39刺激细胞生物能量学，在体外氧化应激内皮细胞中发挥细胞保护作用并防止线粒体DNA的丢失及完整性丧失
Bartosz Szczesny,Katalin Módis,Kazunori Yanagi et al.
Bartosz Szczesny et al.
The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H2S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], on bioenergetics, ...
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer [0.03%]
硫化氢抗炎药物(ATB-346)的化学预防作用增强作用及在实验性结直肠癌中的效果研究
Wagdi Elsheikh,Rory W Blackler,Kyle L Flannigan et al.
Wagdi Elsheikh et al.
Regular use of nonsteroidal anti-inflammatory drugs is associated with a significantly lower incidence of several types of cancer, particularly those affecting the gastrointestinal tract. However, the propensity of these drugs to cause ulce...
Exhaled nitric oxide concentration and decompression-induced bubble formation: An index of decompression severity in humans? [0.03%]
呼出的一氧化氮浓度与减压时气泡形成的关系：人类减压严重程度的指标？
J-M Pontier,P Buzzacott,J Nastorg et al.
J-M Pontier et al.
Introduction: Previous studies have highlighted a decreased exhaled nitric oxide concentration (FE NO) in divers after hyperbaric exposure in a dry chamber or following a wet dive. The underlying mechanisms of this decrea...
Nitric oxide is required for determining root architecture and lignin composition in sunflower. Supporting evidence from microarray analyses [0.03%]
一氧化氮(NO)参与调节向日葵根系构型及木质素组成Ⅱ——基因芯片分析提供的证据
Georgina Corti Monzón,Marcela Pinedo,Julio Di Rienzo et al.
Georgina Corti Monzón et al.
Nitric oxide (NO) is a signal molecule involved in several physiological processes in plants, including root development. Despite the importance of NO as a root growth regulator, the knowledge about the genes and metabolic pathways modulate...
Altered neuronal and endothelial nitric oxide synthase expression in the bladder and urethra of cyclophosphamide-treated rats [0.03%]
环磷酰胺处理大鼠膀胱和尿道神经元和内皮型一氧化氮合酶表达的改变
Maria Sancho,Jose J Ferrero,Domingo Triguero et al.
Maria Sancho et al.
Increased nitric oxide (NO) production seems to play a key role in cyclophosphamide (CYP)-induced cystitis, although the underlying mechanisms and the relative involvement of the different NO synthase (NOS) isoforms remain to be elucidated....
Amarendra N Misra,Radka Vladkova,Ranjeet Singh et al.
Amarendra N Misra et al.
Nitric oxide (NO) is an important signalling molecule in plants under physiological and stress conditions. Here we review the influence of NO on chloroplasts which can be directly induced by interaction with the photosynthetic apparatus by ...
Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study [0.03%]
硝酸盐合酶（NOS）单核苷酸多态性与INTERGENE研究中的冠心病和高血压相关
Anna Levinsson,Anna-Carin Olin,Lena Björck et al.
Anna Levinsson et al.
Objective: Nitric oxide synthase (NOS) exists in three distinct isoforms, each encoded by a specific gene: neuronal NOS (NOS1 gene), inducible NOS (NOS2 gene) and endothelial NOS (NOS3 gene). Single nucleotide polymorphis...
Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro [0.03%]
S-腺苷甲硫氨酸(SAM)，一种半胱氨酸-beta- synthase(CBS)别构激活剂对体外结直肠癌细胞增殖和生物能量学的影响
Katalin Módis,Ciro Coletta,Antonia Asimakopoulou et al.
Katalin Módis et al.
Recent data show that colon cancer cells selectively overexpress cystathionine-β-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation ...
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health [0.03%]
无机硝酸盐在心血管健康方面的临床应用价值证据显示
V Kapil,E Weitzberg,J O Lundberg et al.
V Kapil et al.
The discovery of nitric oxide and its role in almost every facet of human biology opened a new avenue for treatment through manipulation of its canonical signaling and by attempts to augment endogenous nitric oxide generation through provis...
Oscar McCook,Peter Radermacher,Chiara Volani et al.
Oscar McCook et al.
Numerous papers have been published on the role of H2S during circulatory shock. Consequently, knowledge about vascular sulfide concentrations may assume major importance, in particular in the context of "acute on chronic disease", i.e., du...