Hydrogen sulfide ameliorated endothelial dysfunction in hyperhomocysteinemia rats: Mechanism of IRE1α/JNK pathway-mediated autophagy [0.03%]
氢硫酸盐改善高同型半胱氨酸血症大鼠内皮功能障碍：IRE1α/JNK途径介导的自噬机制
Yuan Gao,Jiao Xu,Kaichuan He et al.
Yuan Gao et al.
Previous studies showed that hyperhomocysteinemia (HHcy) induced endothelial dysfunction by endoplasmic reticulum (ER) stress induction and autophagy stimulation. This study aimed to determine the effect of hydrogen sulfide (H2S) in homocys...
An updated mechanistic overview of nitric oxide in drought tolerance of plants [0.03%]
植物抗旱耐性中一氧化氮作用机制的最新研究进展概述
Sakshi Saini,Priyanka Sharma,Pooja Pooja et al.
Sakshi Saini et al.
Drought stress, an inevitable global issue due to climate change, hinders plant growth and yield. Nitric oxide (NO), a tiny gaseous signaling compound is now gaining massive attention from the plant science community due to its unparalleled...
Roshani Gupta,Vijay Kumar,Nikita Verma et al.
Roshani Gupta et al.
In plant physiology, nitric oxide (NO) is a widely used signaling molecule. It is a free radical and an important component of the N-cycle. NO is produced endogenously inside plant cells, where it participates in multiple functions and prov...
Role of Nitric oxide synthase II in cognitive impairment due to experimental cerebral malaria [0.03%]
硝酸氧化酶在实验性脑型疟疾所致认知障碍中的作用研究
Tathiany Igreja da Silva,Tamires da Cunha Fernandes,Emílio Telles de Sá Moreira et al.
Tathiany Igreja da Silva et al.
The role of nitric oxide (NO) in the pathogenesis of cerebral malaria and its cognitive sequelae remains controversial. Cerebral malaria is still the worst complication of Plasmodium falciparum infection, which is characterized by high rate...
The nitration of SIRT6 aggravates neuronal damage during cerebral ischemia-reperfusion in rat [0.03%]
硝酸盐SIRT6加重脑缺血再灌注损伤大鼠的神经元损伤
Bingnan Guo,Bin Ma,Ming Li et al.
Bingnan Guo et al.
Ischemic stroke is a major cause of death and disability. The activation of neuronal nitric oxide synthase (nNOS) and the resulting production of nitric oxide (NO) via NMDA receptor-mediated calcium influx play an exacerbating role in cereb...
Trial of the cerebral perfusion response to sodium nitrite infusion in patients with acute subarachnoid haemorrhage using arterial spin labelling MRI [0.03%]
使用动脉自旋标记MRI检测亚硝酸钠滴定对蛛网膜下腔出血患者脑灌注反应的试验
Martyn Ezra,Edit Franko,Desiree B Spronk et al.
Martyn Ezra et al.
Aneurysmal subarachnoid haemorrhage (SAH) is a devastating subset of stroke. One of the major determinants of outcome is an evolving multifactorial injury occurring in the first 72 hours, known as early brain injury. Reduced nitric oxide (N...
Randomized Controlled Trial
Nitric oxide : biology and chemistry. 2024 Dec 1:153:50-60. DOI:10.1016/j.niox.2024.10.003 2024
Carbon monoxide as a negative feedback mechanism on HIF-1α in the progression of metabolic-associated fatty liver disease [0.03%]
一氧化碳通过抑制缺氧诱导因子HIF-1α参与代谢相关性脂肪肝的发病机制
Yingying Cui,Kai Yang,Chunyu Guo et al.
Yingying Cui et al.
Metabolic-associated fatty liver disease (MAFLD) encompasses various chronic liver conditions, yet lacks approved drugs. Hypoxia-inducible factor-1α (HIF-1α) is pivotal in MAFLD development. Our prior research highlighted the efficacy of ...
The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status [0.03%]
AKT1和二聚状态调节内皮型一氧化氮合酶的线粒体易位分布机制
Xutong Sun,Santiago Moreno Caceres,Manivannan Yegambaram et al.
Xutong Sun et al.
Previously, we have shown that endothelial nitric-oxide synthase (eNOS) dimer levels directly correlate with the interaction of eNOS with hsp90 (heat shock protein 90). Further, the disruption of eNOS dimerization correlates with its redist...
Investigation of the relationships between eNOS T786C, G894T, intron 4 VNTR (4a/b) gene variations and prostate cancer development and progression [0.03%]
eNOS基因T786C、G894T及内含子4VNTR(4a/4b)多态性与前列腺癌发生发展关系的研究
Nevra Alkanli,Arzu Ay,Gokhan Cevik
Nevra Alkanli
Background: This study aimed to investigate the relationships between eNOS T786C, G894T, intron 4 VNTR (4a/b) gene variations and prostate cancer development and progression. ...
Synthesis, structure, spectra, cytotoxicity and photo induced NO release of four isomeric nitrosylruthenium complexes [0.03%]
四个异构硝基钌配合物的合成、结构、光谱、细胞毒性和光致NO释放性质研究
Jia Shi,Yuhua Liu,Shuxiang Jiao et al.
Jia Shi et al.
Four isomeric nitrosyl ruthenium complexes [RuCl(2mqn)(Val)(NO)] (1-4) were prepared (2mqn, 2-methyl-8-hydroxyquinoline; Val, l-valine) and characterized by 1H NMR, 13C NMR, absorption spectrum, electrospray ionization mass spectrometry, an...