Segmentation and classification of dot and non-dot-like fluorescence in situ hybridization signals for automated detection of cytogenetic abnormalities [0.03%]
用于自动检测细胞遗传异常的荧光原位杂交信号分割及分类方法研究
Boaz Lerner,Lev Koushnir,Josepha Yeshaya
Boaz Lerner
Signal segmentation and classification of fluorescence in situ hybridization (FISH) images are essential for the detection of cytogenetic abnormalities. Since current methods are limited to dot-like signal analysis, we propose a methodology...
Exploring microbial genome sequences to identify protein families on the grid [0.03%]
在网格上探索微生物基因组序列来确定蛋白质家族
Yudong Sun,Anil Wipat,Matthew Pocock et al.
Yudong Sun et al.
The analysis of microbial genome sequences can identify protein families that provide potential drug targets for new antibiotics. With the rapid accumulation of newly sequenced genomes, this analysis has become a computationally intensive a...
BAAQ: an infrastructure for application integration and knowledge discovery in bioinformatics [0.03%]
BAAQ：生物信息学中应用程序集成和知识发现的基础设施
Xiujun Gong,Kensuke Nakamura,Hua Yu et al.
Xiujun Gong et al.
The emerging grid computing technologies enable bioinformatics scientists to conduct their researches in a virtual laboratory, in which they share public databases, computational tools as well as their analysis workflows. However, the devel...
Psychiatric consultation record retrieval using scenario-based representation and multilevel mixture model [0.03%]
基于场景表示和多级混合模型的精神病咨询记录检索
Liang-Chih Yu,Chung-Hsien Wu,Fong-Lin Jang
Liang-Chih Yu
Psychiatric consultation record retrieval attempts to help people to efficiently and effectively locate the consultation records relevant to their depressive problems. Consultation records can also make people aware that they are not alone,...
On the classification of prostate carcinoma with methods from spatial statistics [0.03%]
利用空间统计方法分类前列腺癌病理影像
Claudia Wittke,Johannes Mayer,Franz Schweiggert
Claudia Wittke
Gleason grading is a common method used by pathologists to determine the aggressivity of prostate cancer on the basis of histological slide preparations. The advantage of this grading system is a good correlation with the biological behavio...
Optimal search-based gene subset selection for gene array cancer classification [0.03%]
基于搜索的基因子集选择的最优解用于基因数组癌症分类问题研究
Jiexun Li,Hua Su,Hsinchun Chen et al.
Jiexun Li et al.
High dimensionality has been a major problem for gene array-based cancer classification. It is critical to identify marker genes for cancer diagnoses. We developed a framework of gene selection methods based on previous studies. This paper ...
Modeling drug mechanism knowledge using evidence and truth maintenance [0.03%]
基于证据和真理维护的药物作用机制建模方法研究
Richard D Boyce,Carol Collins,John Horn et al.
Richard D Boyce et al.
To protect the safety of patients, it is vital that researchers find methods for representing drug mechanism knowledge that support making clinically relevant drug-drug interaction (DDI) predictions. Our research aims to identify the challe...
Management and analysis of genomic functional and phenotypic controlled annotations to support biomedical investigation and practice [0.03%]
用于支持生物医学研究和实践的基因组功能和表型受控标注的管理和分析
Marco Masseroli
Marco Masseroli
The growing available genomic information provides new opportunities for novel research approaches and original biomedical applications that can provide effective data management and analysis support. In fact, integration and comprehensive ...
Ricky K Taira,Vijayaraghavan Bashyam,Hooshang Kangarloo
Ricky K Taira
A parser for medical free text reports has been developed that is based on a chemistry/physics inspired "field theory" for word-word sentence-level dependencies. The transition from the linguistic world to the world of interacting particles...
Morphological granulometric features of nucleus in automatic bone marrow white blood cell classification [0.03%]
自动骨髓白血球分类中细胞核的形态颗粒特征
Nipon Theera-Umpon,Sompong Dhompongsa
Nipon Theera-Umpon
The proportion of counts of different types of white blood cells in the bone marrow, called differential counts, provides invaluable information to doctors for diagnosis. Due to the tedious nature of the differential white blood cell counti...