Graham Hepworth,Brad J Biggerstaff
Graham Hepworth
In the estimation of proportions by pooled testing, the MLE is biased, and several methods of correcting the bias have been presented in previous studies. We propose a new estimator based on the bias correction method introduced by Firth (B...
Maximum Pairwise Pseudo-Likelihood Estimation of the Covariance Matrix from Left-Censored Data [0.03%]
基于左删失数据的协方差矩阵的最大成对伪似然估计
Michael P Jones,Sarah S Perry,Peter S Thorne
Michael P Jones
Toxicological studies often depend on laboratory assays that have thresholds below which environmental pollutants cannot be measured with accuracy. Exposure levels below this limit of detection may well be toxic and hence it is vital to use...
Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting [0.03%]
一种用于风险分析中高度相关数据的加权分位数和回归方法及其特征刻画研究
Caroline Carrico,Chris Gennings,David C Wheeler et al.
Caroline Carrico et al.
In risk evaluation, the effect of mixtures of environmental chemicals on a common adverse outcome is of interest. However, due to the high dimensionality and inherent correlations among chemicals that occur together, the traditional methods...
Uncertainty Analysis for Computationally Expensive Models with Multiple Outputs [0.03%]
多输出计算昂贵模型的不确定性分析
David Ruppert,Christine A Shoemaker,Yilun Wang et al.
David Ruppert et al.
Bayesian MCMC calibration and uncertainty analysis for computationally expensive models is implemented using the SOARS (Statistical and Optimization Analysis using Response Surfaces) methodology. SOARS uses a radial basis function interpola...
Bayesian 2-Stage Space-Time Mixture Modeling With Spatial Misalignment of the Exposure in Small Area Health Data [0.03%]
基于贝叶斯二阶段时空混合模型的小区域健康数据暴露量空间错配研究
Andrew B Lawson,Jungsoon Choi,Bo Cai et al.
Andrew B Lawson et al.
We develop a new Bayesian two-stage space-time mixture model to investigate the effects of air pollution on asthma. The two-stage mixture model proposed allows for the identification of temporal latent structure as well as the estimation of...
Exact-Permutation Based Sign Tests for Clustered Binary Data via Weighted and Unweighted Test Statistics [0.03%]
基于精确置换的聚类二元数据加权与去权重符号检验方法
Janie McDonald,Patrick D Gerard,Christopher S McMahan et al.
Janie McDonald et al.
Clustered binary data occur frequently in many application areas. When analyzing data of this form, ignoring key features, such as the intracluster correlation, may lead to inaccurate inference; e.g., inflated Type I error rates. For cluste...
A Semi-parametric Bayesian Approach for Differential Expression Analysis of RNA-seq Data [0.03%]
用于RNA序数据的差异表达分析的半参贝叶斯方法
Fangfang Liu,Chong Wang,Peng Liu
Fangfang Liu
RNA-sequencing (RNA-seq) technologies have revolutionized the way agricultural biologists study gene expression as well as generated a tremendous amount of data waiting for analysis. Detecting differentially expressed genes is one of the fu...
Estimability Analysis and Optimal Design in Dynamic Multi-scale Models of Cardiac Electrophysiology [0.03%]
心脏电生理动态多尺度模型的可估性分析与最优设计研究
Matthew S Shotwell,Richard A Gray
Matthew S Shotwell
We present an applied approach to optimal experimental design and estimability analysis for mechanistic models of cardiac electrophysiology, by extending and improving on existing computational and graphical methods. These models are 'multi...
Empirical Bayes analysis of RNA-seq data for detection of gene expression heterosis [0.03%]
基于RNA测序数据的基因表达杂种优势的经验Bayes分析方法研究基因表达杂种优势的经验贝叶斯分析法研究基于RNA测序数据
Jarad Niemi,Eric Mittman,Will Landau et al.
Jarad Niemi et al.
An important type of heterosis, known as hybrid vigor, refers to the enhancements in the phenotype of hybrid progeny relative to their inbred parents. Although hybrid vigor is extensively utilized in agriculture, its molecular basis is stil...
Hierarchical Modeling and Differential Expression Analysis for RNA-seq Experiments with Inbred and Hybrid Genotypes [0.03%]
基于基因型杂交和纯合品系的rna测序实验的层次模型及差异表达分析方法研究
Andrew Lithio,Dan Nettleton
Andrew Lithio
The performance of inbred and hybrid genotypes is of interest in plant breeding and genetics. High-throughput sequencing of RNA (RNA-seq) has proven to be a useful tool in the study of the molecular genetic responses of inbreds and hybrids ...