Scale-Up of a Rh-Catalyzed Asymmetric sp3-sp2 Suzuki-Miyaura-Type Reaction [0.03%]
Rh催化的手性sp3-sp2苏菲吉-宫浦型反应的放大合成研究
Laura Cunningham,Mireia Sidera Portela,Stephen P Fletcher
Laura Cunningham
Csp2-Csp2 Suzuki-Miyaura couplings (SMCs) are ubiquitous in the synthesis of small molecules, but analogous Csp2-Csp3 bond-forming SMCs are rare, especially asymmetric variants. Recently, we developed a series of Rh-catalyzed couplings betw...
Air-Stable Iron-Based Precatalysts for Suzuki-Miyaura Cross-Coupling Reactions between Alkyl Halides and Aryl Boronic Esters [0.03%]
用于烷基卤化物和芳基硼酸酯之间的Suzuki-Miyaura交叉偶联反应的空气稳定型铁基预催化剂
Alexander S Wong,Bufan Zhang,Bo Li et al.
Alexander S Wong et al.
The development of an air-stable iron(III)-based precatalyst for the Suzuki-Miyaura cross-coupling reaction of alkyl halides and unactivated aryl boronic esters is reported. Despite benefits to cost and toxicity, the proclivity of iron(II)-...
Continuous Formation of Limonene Carbonates in Supercritical Carbon Dioxide [0.03%]
超critical二氧化碳中蒈烯碳酸酯的连续形成
Philipp Mikšovsky,Elias N Horn,Shaghayegh Naghdi et al.
Philipp Mikšovsky et al.
We present a continuous flow method for the conversion of bioderived limonene oxide and limonene dioxide to limonene carbonates using carbon dioxide in its supercritical state as a reagent and sole solvent. Various ammonium- and imidazolium...
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease [0.03%]
一种用于治疗干眼病的先导化合物UAMC-00050（选择性丝氨酸蛋白酶uPA抑制剂）的改进合成方法
Davide Ceradini,Pavel Cacivkins,Alba Ramos-Llorca et al.
Davide Ceradini et al.
The α-aminophosphonate UAMC-00050, a newly developed trypsin-like serine protease inhibitor, is a lead compound for the treatment of dry eye syndrome and ocular inflammation. The medicinal chemistry route developed at the University of Ant...
Giacomo Trapasso,Giovanna Mazzi,Beatriz Chícharo et al.
Giacomo Trapasso et al.
5-Hydroxymethylfurfural (HMF) is a bio-based platform chemical that can be used as a building block to produce several compounds with diverse applications. Even though HMF synthesis holds promise for a greener future, the current state of t...
High-Productivity Single-Pass Electrochemical Birch Reduction of Naphthalenes in a Continuous Flow Electrochemical Taylor Vortex Reactor [0.03%]
一种连续流动电化学Taylor旋涡反应器中萘单步高效Birch还原方法
Darren S Lee,Ashley Love,Zakaria Mansouri et al.
Darren S Lee et al.
We report the development of a single-pass electrochemical Birch reduction carried out in a small footprint electrochemical Taylor vortex reactor with projected productivities of >80 g day-1 (based on 32.2 mmol h-1), using a modified versio...
Rate of Formation of Industrial Lubricant Additive Precursors from Maleic Anhydride and Polyisobutylene [0.03%]
从邻苯二甲酸酐和聚异丁烯合成工业润滑油添加剂前驱体的反应速率
Jessica Streets,Nicolas Proust,Dixit Parmar et al.
Jessica Streets et al.
The Alder-ene reaction of neat polyisobutylene (PIB) and maleic anhydride (MAA) to produce the industrially important lubricant additive precursor polyisobutylene succinic anhydride (PIBSA) is studied at 150-180 °C. Under anaerobic conditi...
Corrections to "An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer" [0.03%]
对“使用多克级微波固相合成仪进行Eptifibatide原料药的从实验室到中试的cGMP生产”的优化及改进
Annunziata D&#x;Ercole,Lorenzo Pacini,Giuseppina Sabatino et al.
Annunziata D&#x;Ercole et al.
[This corrects the article DOI: 10.1021/acs.oprd.1c00368.]. © 2022 The Authors. Published by American Chemical Society.
Published Erratum
Organic process research & development. 2022 Aug 19;26(8):2540. DOI:10.1021/acs.oprd.2c00224 2022
Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppm [0.03%]
钯催化偶联反应：关于催化剂量描述符mol％和ppm的重要性
Christopher S Horbaczewskyj,Ian J S Fairlamb
Christopher S Horbaczewskyj
This Review examines parts per million (ppm) palladium concentrations in catalytic cross-coupling reactions and their relationship with mole percentage (mol %). Most studies in catalytic cross-coupling chemistry have historically focused on...
Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol-Ene/Cyclization Sequence in Continuous Flow [0.03%]
连续流动下光化学硫醇-烯/环化串联反应合成噻吗咯啉
Alexander Steiner,Ryan C Nelson,Doris Dallinger et al.
Alexander Steiner et al.
A procedure for the continuous flow generation of thiomorpholine in a two-step telescoped format was developed. The key step was the photochemical thiol-ene reaction of cysteamine hydrochloride and vinyl chloride as low-cost starting materi...