Coaxial Dielectric Spectroscopy as an In-Line Process Analytical Technique for Reaction Monitoring [0.03%]
同铀介电谱法作为过程分析技术用于反应监控
Desiree M Dalligos,Michael J Pilling,Georgios Dimitrakis et al.
Desiree M Dalligos et al.
The suitability of broadband dielectric spectroscopy (DS) as a tool for in-line (in situ) reaction monitoring is demonstrated. Using the esterification of 4-nitrophenol as a test-case, we show that multivariate analysis of time-resolved DS ...
Correction to "Safety Considerations and Proposed Workflow for Laboratory Scale Chemical Synthesis by Ball Milling" [0.03%]
有关“磨球机实验室规模化学合成的安全考虑及工作流程建议”的勘误通知
Ian Priestley,Claudio Battilocchio,Andrei Iosub et al.
Ian Priestley et al.
[This corrects the article DOI: 10.1021/acs.oprd.2c00226.]. © 2023 The Authors. Published by American Chemical Society.
Published Erratum
Organic process research & development. 2023 Jun 7;27(6):1154. DOI:10.1021/acs.oprd.3c00155 2023
Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor [0.03%]
毫克数量级 largazole 的克级工艺优化及其全合成
Qi-Yin Chen,Pravin R Chaturvedi,Hendrik Luesch
Qi-Yin Chen
Herein we describe the research and development of the process for the scale-up total synthesis of largazole, a potent class I selective histone deacetylase (HDAC) inhibitor, a potential anticancer agent and also useful for the treatment of...
Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir [0.03%]
用于HIV-1整合酶链转移抑制剂多替拉韦、比克替拉韦和卡博特韦的共同关键吡啶酮羧酸前体的合成方法
Pankaj S Mahajan,Terrence R Burke Jr
Pankaj S Mahajan
Dolutegravir (DTG), Bictegravir (BIC), and Cabotegravir (CAB) are the second-generation integrase strand transfer inhibitors (INSTIs) that have been FDA-approved for the treatment of HIV-1 infection. Preparation of these INSTIs utilizes the...
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm [0.03%]
利用自动化图像处理算法确定相分离动力学
James Daglish,A John Blacker,Gregory de Boer et al.
James Daglish et al.
The problems of extracting products efficiently from reaction workups are often overlooked. Issues such as emulsions and rag layer formation can cause long separation times and slow production, thus resulting in manufacturing inefficiencies...
Tanpreet Kaur,Xia Shao,Mami Horikawa et al.
Tanpreet Kaur et al.
This report describes a comparison of four different routes for the clinical-scale radiosynthesis of the κ-opioid receptor antagonist [11C]LY2795050. Palladium-mediated radiocyanation and radiocarbonylation of an aryl iodide precursor as w...
Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid [0.03%]
连续流动下以均相锰催化体系和过氧酸为氧化剂的烯烃环氧化反应研究
Ailbhe A Ryan,Seán D Dempsey,Megan Smyth et al.
Ailbhe A Ryan et al.
Epoxidation of alkenes is a valuable transformation in the synthesis of fine chemicals. Described herein are the design and development of a continuous flow process for carrying out the epoxidation of alkenes with a homogeneous manganese ca...
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling [0.03%]
通过机理建模对活性药物成分的过滤和洗涤进行数字设计
Sara Ottoboni,Cameron J Brown,Bhavik Mehta et al.
Sara Ottoboni et al.
To facilitate integrated end-to-end pharmaceutical manufacturing using digital design, a model capable of transferring material property information between operations to predict product attributes in integrated purification processes has b...
Temperature Correction of Spectra to Improve Solute Concentration Monitoring by In Situ Ultraviolet and Mid-Infrared Spectrometries toward Isothermal Local Model Performance [0.03%]
通过现场紫外和中红外光谱法向等温局部模型性能提高溶质浓度监测的光谱温度校正
Magdalene W S Chong,Thomas McGlone,Ching Yee Chai et al.
Magdalene W S Chong et al.
Changes in temperature can significantly affect spectroscopic-based methods for in situ monitoring of processes. As varying temperature is inherent to many processes, associated temperature effects on spectra are unavoidable, which can hind...
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena [0.03%]
用于分析实验室及过程规模混合现象的运动分析计算机视觉技术
Henry Barrington,Alan Dickinson,Jake McGuire et al.
Henry Barrington et al.
A software platform for the computer vision-enabled analysis of mixing phenomena of relevance to process scale-up is described. By bringing new and known time-resolved mixing metrics under one platform, hitherto unavailable comparisons of p...