A Coalescing Filter for Liquid-Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry [0.03%]
连续流动化学中用于液液分离和多级萃取的汇流过滤器
James Daglish,A John Blacker,Gregory de Boer et al.
James Daglish et al.
Presented here is the design and performance of a coalescing liquid-liquid filter, based on low-cost and readily available meltblown nonwoven substrates for separation of immiscible phases. The performance of the coalescer was determined ac...
Process Intensification of the Continuous Synthesis of Bio-Derived Monomers for Sustainable Coatings Using a Taylor Vortex Flow Reactor [0.03%]
采用泰勒涡流反应器连续合成可持续涂料生物单体的工艺强化
Matthew D Edwards,Matthew T Pratley,Charles M Gordon et al.
Matthew D Edwards et al.
We describe the optimization and scale-up of two consecutive reaction steps in the synthesis of bio-derived alkoxybutenolide monomers that have been reported as potential replacements for acrylate-based coatings (Sci. Adv.2020, 6, eabe0026)...
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode [0.03%]
连续流动Baldwin重排工艺的开发及其与传统批量模式的比较
Arlene Bonner,Marcus Baumann
Arlene Bonner
A new and highly efficient continuous flow process is presented for the synthesis of aziridines via the thermal Baldwin rearrangement. The process was initially explored using traditional batch synthesis techniques but suffered from moderat...
Selective Thermal Deprotection of N-Boc Protected Amines in Continuous Flow [0.03%]
连续流动下N-Boc保护胺的选择性热脱保护
Michelle-Rose Ryan,Denis Lynch,Stuart G Collins et al.
Michelle-Rose Ryan et al.
Thermal N-Boc deprotection of a range of amines is readily effected in continuous flow, in the absence of an acid catalyst. While the optimum results were obtained in methanol or trifluoroethanol, deprotection can be effected in a range of ...
Development of Lab-Scale Continuous Stirred-Tank Reactor as Flow Process Tool for Oxidation Reactions Using Molecular Oxygen [0.03%]
基于分子氧氧化反应的实验室规模连续搅拌罐流体重力工具的发展研究
Ursina Gnädinger,Dario Poier,Claudio Trombini et al.
Ursina Gnädinger et al.
The use of sustainable oxidants is of great interest to the chemical industry, considering the importance of oxidation reactions for the manufacturing of chemicals and society's growing awareness of its environmental impact. Molecular oxyge...
Effect of Nitrogen, Air, and Oxygen on the Kinetic Stability of NAD(P)H Oxidase Exposed to a Gas-Liquid Interface [0.03%]
氮气、空气和氧气对暴露在气液界面的NAD(P)H氧化酶动力学稳定性的影响
Jingyu Wang,Elif Erdem,John M Woodley
Jingyu Wang
Biocatalytic oxidation is an interesting prospect for the selective synthesis of active pharmaceutical intermediates. Bubbling air or oxygen is considered as an efficient method to increase the gas-liquid interface and thereby enhance oxyge...
Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol [0.03%]
追求一致：实现一致性聚乙二醇的进展与挑战综述
Cláudia Bento,Marianna Katz,Maria M M Santos et al.
Cláudia Bento et al.
Poly(ethylene glycol) (PEG) is the polymer of choice in drug delivery systems due to its biocompatibility and hydrophilicity. For over 20 years, this polymer has been widely used in the drug delivery of small drugs, proteins, oligonucleotid...
A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid [0.03%]
叠氮
Hanuman P Kalmode,Ongolu Ravikumar,Dinesh J Paymode et al.
Hanuman P Kalmode et al.
Sutezolid is an in-development thiomorpholine derivative of the FDA-approved tuberculosis (TB) treatment linezolid. Current synthetic routes for preparing sutezolid start with thiomorpholine as a key structural building block; unfortunately...
Hui Xiao,Yanyue Feng,William R F Goundry et al.
Hui Xiao et al.
Separation and purification in organic solvents are indispensable procedures in pharmaceutical manufacturing. However, they still heavily rely on the conventional separation technologies of distillation and chromatography, resulting in high...
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients [0.03%]
集成过滤与洗涤模型：活性药物成分过滤和洗涤杂质去除的优化
Bhavik A Mehta,Ekaterina Gramadnikova,Cameron J Brown et al.
Bhavik A Mehta et al.
A digital design tool that can transfer material property information between unit operations to predict the product attributes in integrated purification processes has been developed to facilitate end-to-end integrated pharmaceutical manuf...