Development of a Cryogenic Flow Reactor to Optimize Glycosylation Reactions Based on the Active Donor Intermediate [0.03%]
基于活性供体中间体优化糖基化反应的低温流动反应器开发
Vanessa A Jones,Gideon Q Bennett,Clay S Bennett
Vanessa A Jones
The development of a continuous flow reactor for stereospecific glycosylation reactions with deoxy sugars is described. This apparatus that permits optimizing the selectivity of glycosylation reactions based on the stability of the activate...
PDI-Functionalized Glass Beads: Efficient, Metal-Free Heterogeneous Photocatalysts Suitable for Flow Photochemistry [0.03%]
基于PDI功能化玻璃珠的高效、无金属光催化剂及其流动化学反应研究
Hamza Ali,Ifty Ahmed,Karen Robertson et al.
Hamza Ali et al.
Perylene diimides (PDI) have an extraordinary ability to activate both energy and electron transfer processes upon light excitation; however, their extremely low solubility has hindered their wide use as photocatalysts. Here, we show that t...
A Computer Vision Approach toward Verifying CFD Models of Stirred Tank Reactors [0.03%]
基于计算机视觉的搅拌反应器流场模型验证方法
Calum Fyfe,Henry Barrington,Charles M Gordon et al.
Calum Fyfe et al.
Mixing is one of the most important nonchemical considerations in the design of scalable processes. While noninvasive imaging approaches to deliver a quantifiable understanding of mixing dynamics are well-known, the use of imaging to verify...
Synthetic Process Development of (R)-(+)-1,2-Epoxy-5-hexene: An Important Chiral Building Block [0.03%]
(R)-(+)-1,2-环氧-5-己烯的合成工艺开发：一种重要的手性砌块
Daryl Guthrie,John M Saathoff,Rajkumar Lalji Sahani et al.
Daryl Guthrie et al.
Herein, we describe two practical approaches to synthesize (R)-(+)-1,2-epoxy-5-hexene from inexpensive and readily available raw materials and reagents. The first approach is a two-step sequence, involving an epoxidation with meta-chloroper...
Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air [0.03%]
连续流动体系下以空气为氧化剂的苯基α-位氧化反应研究
Ruairi Bannon,Gary Morrison,Megan Smyth et al.
Ruairi Bannon et al.
A continuous flow approach for the aerobic photo-oxidation of benzylic substrates to ketone and aldehyde products is presented. The resulting process exploits UV-A LEDs (375 nm) in combination with a Corning AFR reactor that ensures effecti...
Automated Continuous Crystallization Platform with Real-Time Particle Size Analysis via Laser Diffraction [0.03%]
集成实时激光衍射颗粒尺寸分析的连续结晶平台
Sayan Pal,Arun Pankajakshan,Maximilian O Besenhard et al.
Sayan Pal et al.
The fourth industrial revolution is gaining momentum in the pharmaceutical industry. However, particulate processes and suspension handling remain big challenges for automation and the implementation of real-time particle size analysis. Mor...
Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes [0.03%]
用于醛的选择性和可放大的合成的TEMPO/NaOCl流氧化醇研究
Parth Naik,Jorge García-Lacuna,Patrick O&#x;Neill et al.
Parth Naik et al.
A simple and benign continuous flow oxidation protocol for the selective conversion of primary and secondary alcohols into their respective aldehyde and ketone products is reported. This approach makes use of catalytic amounts of TEMPO in c...
Flow Chemistry for Synthesis of 2-(C-Glycosyl)acetates from Pyranoses via Tandem Wittig and Michael Reactions [0.03%]
通过串联的Wittig和Michael反应从吡喃糖合成2-（C-糖基）乙酸酯的流动化学法
Jack J Bennett,Paul V Murphy
Jack J Bennett
C-Glycosyl compounds (C-glycosides) are a class of saccharide derivatives with improved stability over their O-linked counterparts. This paper reports the synthesis of several trans-2-(C-glycosyl)acetates via a tandem Wittig-Michael reactio...
Copper-Catalyzed Continuous-Flow Transfer Hydrogenation of Nitroarenes to Anilines: A Scalable and Reliable Protocol [0.03%]
铜催化下硝基芳烃到苯胺的连续流动转移氢化：一种可放大量生产的可靠工艺
Katia Martina,Maria Jesus Moran,Maela Manzoli et al.
Katia Martina et al.
A robust supported catalyst that is made up of copper nanoparticles on Celite has been successfully prepared for the selective transfer hydrogenation of aromatic nitrobenzenes to anilines under continuous flow. The method is efficient and e...
Enantioselective Synthesis in Continuous Flow: Polymer-Supported Isothiourea-Catalyzed Enantioselective Michael Addition-Cyclization with α-Azol-2-ylacetophenones [0.03%]
连续流动中的不对称合成：多肽固定化异硫脲催化的α-azol-2-基乙酰苯酮的对映选择性迈克尔加成-环化反应
Zhanyu Zhou,Kevin Kasten,Tengfei Kang et al.
Zhanyu Zhou et al.
A packed reactor bed incorporating a polymer-supported isothiourea HyperBTM catalyst derivative has been used to promote the enantioselective synthesis of a range of heterocyclic products derived from α-azol-2-ylacetophenones and -acetamid...