Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow [0.03%]
连续流动中手性胺的闪蒸热外消旋化：使用实验设计和多变量瞬态流探索反应空间
Matthew J Takle,Linden Schrecker,Benjamin J Deadman et al.
Matthew J Takle et al.
The robustness of the flash thermal racemization of optically active 1-phenylethylamine over Pd/γ-Al2O3 was studied by applying split-plot design-of-experiments (DoE), where the effects of temperature, flow rate, and concentration (3-facto...
Dan Trunov,Jan Ižovský,Josef Beranek et al.
Dan Trunov et al.
The choice of method for drug amorphization depends on various factors, including the physicochemical properties of the active pharmaceutical ingredients, the desired formulation, and scalability requirements. It is often important to consi...
Scale-Up of Continuous Metallaphotoredox Catalyzed C-O Coupling to a 10 kg-Scale Using Small Footprint Photochemical Taylor Vortex Flow Reactors [0.03%]
采用小型光化学Taylor旋涡流反应器将连续金属光氧化还原催化的C-O偶联放大至10千克规模
Rodolfo I Teixeira,Toby H Waldron Clarke,Ashley Love et al.
Rodolfo I Teixeira et al.
We report the development and optimization of a scalable flow process for metallaphotoredox (Ir/Ni) C-O coupling, a mild and efficient approach for forming alkyl-aryl ethers, a common motif in medicinal and process chemistry settings. Time-...
Matthew Frederick Lopez Villena,Zachary Dean Doorenbos,Kyle Thomas Sullivan et al.
Matthew Frederick Lopez Villena et al.
Control of powder properties is crucial for industrial processes across the food, pharmaceutical, agriculture, and mineral processing industries, and granulation is an important tool for providing agglomerated particles with controllable pr...
Can Ultrasound Replace Seeding in Flow Reactive Crystallization of an Aromatic Amine? [0.03%]
超声波能否替代晶种在芳香胺流反应结晶中的作用？
Biyu Zhang,Georgios D Stefanidis,Tom Van Gerven
Biyu Zhang
Continuous crystallization has gained substantial interest due to its high product reproducibility, high labor efficiency, and low capital and production costs. Continuous seeding is preferable and often even required in the application of ...
Facile Recovery and Recycling of a Soluble Dirhodium Catalyst in Asymmetric Cyclopropanation via a Catalyst-in-Bag System [0.03%]
利用袋式催化体系在不对称环丙烷化反应中实现二铑催化剂的快速回收及循环使用
UnJin Ryu,Duc Ly,Kristin Shimabukuro et al.
UnJin Ryu et al.
A catalyst-in-bag system facilitates the recovery and recycling of chiral dirhodium carboxylate catalysts used for enantioselective, intermolecular cyclopropanation. The catalyst-in-bag system incorporates a soluble enantioselective dirhodi...
Synthesis of N-Bromo and N-Iodo Imides: A Rapid Redox-Neutral and Bench Stable Process [0.03%]
红氧条件稳定的N-溴和N-碘亚胺的合成
Ankush Chakraborty,Bardia Soltanzadeh,Nicholas R Wills et al.
Ankush Chakraborty et al.
This report presents a rapid, ecofriendly technique for the formation of commonly used N-bromo and N-iodinating reagents by reacting readily available N-chloro derivatives with inorganic bromide and iodide salts. All reagents were easily ha...
Electrochemical Trifluoromethylation of Enamides under Microflow Conditions [0.03%]
微流控电化学条件下 enamides 的 trifluoromethyl化反应
Anna Vanluchene,Tomas Horsten,Eli Bonneure et al.
Anna Vanluchene et al.
The development of sustainable trifluoromethylations of enamides is of great interest to the pharmaceutical industry. Herein, we demonstrate a sustainable direct electrochemical trifluoromethylation method in a microflow cell, using Langloi...
Reactivities of N-Nitrosamines against Common Reagents and Reaction Conditions [0.03%]
N-亚硝胺与常用试剂和反应条件的反应性
George A Hodgin,Michael J Burns,Benjamin J Deadman et al.
George A Hodgin et al.
The knowledge of the reactivity of N-nitrosamines (NSAs) with common organic reagents in synthesis is essential in determining their presence in pharmaceutical products, if formed and retained during synthesis. In this study, we carried out...
Highly Selective Electrosynthesis of 1 H-1-Hydroxyquinol-4-ones-Synthetic Access to Versatile Natural Antibiotics [0.03%]
高选择性电合成1H-1-羟基喹诺-4-酮：多种天然抗生素的合成途径
Tobias Prenzel,Nils Schwarz,Jasmin Hammes et al.
Tobias Prenzel et al.
1H-1-Hydroxyquinolin-4-ones represent a broad class of biologically active heterocycles having an exocyclic N,O motif. Electrosynthesis offers direct, highly selective, and sustainable access to 1-hydroxyquinol-4-ones by nitro reduction. A ...