Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C-H Functionalization Sequences [0.03%]
通过Rh(I)催化的C-H官能团化序列合成多样的四氢吡啶类化合物
Tehetena Mesganaw,Jonathan A Ellman
Tehetena Mesganaw
A Rh-catalyzed C-H bond activation/alkenylation/electrocyclization cascade reaction provides diverse 1,2-dihydropyridines from simple and readily available precursors. The reaction can be carried out at low (
PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics [0.03%]
实用的合成、新的配方和杂环芳烃的脱氧氟化反应研究：PhenoFluor
Teppei Fujimoto,Fabian Becker,Tobias Ritter
Teppei Fujimoto
We report a practical synthesis method of the reagent PhenoFluor on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and...
Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli [0.03%]
工程化大肠杆菌手性还原 cofactor 再生策略的影响分析及千克级生产实践
Dimitri Dascier,Spiros Kambourakis,Ling Hua et al.
Dimitri Dascier et al.
This study was designed to determine whether whole cells or crude enzyme extracts are more effective for preparative-scale ketone reductions by dehydrogenases as well as learning which cofactor regeneration scheme is most effective. Based o...
Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts [0.03%]
采用特定生物催化剂制备普级、二级和三级胺的非对映选择性研究
Wolfgang Kroutil,Eva-Maria Fischereder,Christine S Fuchs et al.
Wolfgang Kroutil et al.
This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primary amines from the corresponding ketones a...
A practical and scalable manufacturing process for an anti-fungal agent, Nikkomycin Z [0.03%]
一种实用且可扩展的抗真菌剂Nikkomycin Z的制造工艺
Christopher J Stenland,Lev G Lis,Frederick J Schendel et al.
Christopher J Stenland et al.
A scalable and reliable manufacturing process for Nikkomycin Z HCl on a 170 g scale has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the fina...
Barry M Trost
Barry M Trost
The ability to control the alkylation of organic substrates becomes ever more powerful by using metal catalysts. Among the major benefits of metal catalysis is the possibility to perform such processes asymmetrically using only catalytic am...
Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres [0.03%]
烯丙基胺在(E)式烯烃肽等效物合成中的关键作用
Erin M Skoda,Gary C Davis,Peter Wipf
Erin M Skoda
Nucleophilic imine additions with vinyl organometallics have developed into efficient, high yielding, and robust methodologies to generate structurally diverse allylic amines. We have used the hydrozirconation-transmetalation-imine addition...
Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods [0.03%]
脱氢化碳碳键形成 stereoselective方法简述
Abbas Hassan,Michael J Krische
Abbas Hassan
Hydrogenation of π-unsaturated reactants in the presence of carbonyl compounds or imines promotes reductive C-C coupling, providing a byproduct-free alternative to stoichiometric organometallic reagents in an ever-increasing range of C=X (...
Rhodium-Catalyzed C-H Amination - An Enabling Method for Chemical Synthesis [0.03%]
铑催化C-H氨化反应在化学合成中的应用
J Du Bois
J Du Bois
Reaction methods for selective C-H amination are finding ever-increasing utility for the preparation of nitrogen-derived fine chemicals. This brief account highlights the remarkable versatility of dirhodium-based catalysts for promoting oxi...
First Multi-gram Preparation SCP-123, A Novel Water Soluble Analgesic [0.03%]
新型水溶性止痛剂SCP-123的第一阶段多剂量试验报告
Lei Miao,Liang Xu,Kenneth W Narducy et al.
Lei Miao et al.
A short multi-gram process for the preparation of the analgesic compound SCP-123 (4) and its sodium salt has been developed.