Advances in Photocatalysis: A Microreview of Visible Light Mediated Ruthenium and Iridium Catalyzed Organic Transformations [0.03%]
光催化进展：钌和铱催化的可见光介导的有机转化的微型综述
Jon I Day,Kip Teegardin,Jimmie Weaver et al.
Jon I Day et al.
Photocatalytic organic transformations utilizing ruthenium and iridium complexes have garnered significant attention due to the access they provide to new synthetic spaces through new reaction mechanisms. A survey of the photophysical data ...
Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Benzylic Ethers with Isotopically-Labeled Grignard Reagents [0.03%]
用于同位素标记格氏试剂的苯基醚的镍催化立体选择性交叉偶联反应
David D Dawson,Elizabeth R Jarvo
David D Dawson
In this manuscript we highlight the potential of stereospecific nickel-catalyzed cross-coupling reactions for applications in the pharmaceutical industry. Using an inexpensive and sustainable nickel catalyst, we report a gram-scale Kumada c...
Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Cyclic Electrophiles [0.03%]
钯催化芳基硼酸对α,β-不饱和环电性底物的不对称加成反应
Samantha E Shockley,Jeffrey C Holder,Brian M Stoltz
Samantha E Shockley
This account describes our laboratory's efforts in the development of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic conjugate acceptors. Specifically, we highlight the study of this transformation in the...
Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle [0.03%]
一种手性Brønsted酸碱催化剂体系催化的间歇流动反应构建对映纯芳硝基甲烷化合物及其循环利用研究
Sergey V Tsukanov,Martin D Johnson,Scott A May et al.
Sergey V Tsukanov et al.
A stereoselective aza-Henry reaction between an arylnitromethane and Boc-protected aryl aldimine using a homogeneous Brønsted acid-base catalyst was translated from batch format to an automated intermittent-flow process. This work demonstr...
Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry [0.03%]
九种有机溶剂在制药行业中好氧氧化相关温度和压力下的实验极限氧气浓度上限值测定研究报告
Paul M Osterberg,Jeffry K Niemeier,Christopher J Welch et al.
Paul M Osterberg et al.
Applications of aerobic oxidation methods in pharmaceutical manufacturing are limited in part because mixtures of oxygen gas and organic solvents often create the potential for a flammable atmosphere. To address this issue, limiting oxygen ...
Why You Really Should Consider Using Palladium-Catalyzed Cross-Coupling of Silanols and Silanolates [0.03%]
钯催化硅醇和硅酸酯交叉偶联反应的使用理由
Scott E Denmark,Andrea Ambrosi
Scott E Denmark
The transition metal-catalyzed cross-coupling of organometallic nucleophiles derived from tin, boron, and zinc with organic electrophiles enjoys a preeminent status among modern synthetic methods for the formation of carbon-carbon bonds. In...
Closed-Loop Multitarget Optimization for Discovery of New Emulsion Polymerization Recipes [0.03%]
用于发现新型乳液聚合法的闭环多目标优化法
Claudia Houben,Nicolai Peremezhney,Alexandr Zubov et al.
Claudia Houben et al.
Self-optimization of chemical reactions enables faster optimization of reaction conditions or discovery of molecules with required target properties. The technology of self-optimization has been expanded to discovery of new process recipes ...
Michael G Campbell,Tobias Ritter
Michael G Campbell
In this brief account, we review work from our lab with a focus on late-stage introduction of fluorine and fluorinated functional groups into small molecules. We attempt to highlight practical developments, which we believe may have potenti...
Continuous Flow Aerobic Alcohol Oxidation Reactions Using a Heterogeneous Ru(OH) x /Al2O3 Catalyst [0.03%]
连续流动下使用杂多Ru(OH)x/Al2O3催化剂氧化醇类反应
David S Mannel,Shannon S Stahl,Thatcher W Root
David S Mannel
Ru(OH) x /Al2O3 is among the more versatile catalysts for aerobic alcohol oxidation and dehydrogenation of nitrogen heterocycles. Here, we describe the translation of batch reactions to a continuous-flow method that enables high steady-stat...
Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C-H Functionalization Sequence [0.03%]
通过Rh(I)催化C-H官能团化序列制备高度取代的四氢吡啶类化合物
Tehetena Mesganaw,Jonathan A Ellman
Tehetena Mesganaw
We report a Rh(I)-catalyzed C-H activation/alkenylation/electrocyclization cascade and subsequent reduction for the synthesis of highly substituted tetrahydropyridines. These products can be accessed on a gram scale with low catalyst loadin...