Biobased Chemicals: 1,2,4-Benzenetriol, Selective Deuteration and Dimerization to Bifunctional Aromatic Compounds [0.03%]
生物基化学品：1,2,4-苯三酚的选择氘化和二聚化生成双官能团芳香化合物
Caelan Randolph,Ciaran W Lahive,Selim Sami et al.
Caelan Randolph et al.
1,2,4-Benzenetriol (BTO), sourced from the carbohydrate-derived platform chemical 5-hydroxylmethylfurfural (HMF), is an interesting starting point for the synthesis of various biobased aromatic products. However, BTO readily undergoes dimer...
Toward Upscaled Biocatalytic Preparation of Lactone Building Blocks for Polymer Applications [0.03%]
迈向规模化生物催化制备应用于聚合物的内酯单体研究
Marie A F Delgove,Matthew T Elford,Katrien V Bernaerts et al.
Marie A F Delgove et al.
Although Baeyer-Villiger monooxygenases (BVMOs) have gained attention in recent years, there are few cases of their upscaled application for lactone synthesis. A thermostable cyclohexanone monooxygenase from Thermocrispum municipale (TmCHMO...
Marc Escribà-Gelonch,Volker Hessel,Manuel C Maier et al.
Marc Escribà-Gelonch et al.
A continuous tandem in-line evaporation-crystallization is presented. The process includes an in-line solvent-swap step, suitable to be coupled to a capillary based cooler. As a proof of concept, this setup is tested in a direct in-line ace...
Microflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp [0.03%]
采用紫外线灯强化维生素D3合成的微流体高温高压法
Marc Escribà-Gelonch,Timothy Noël,Volker Hessel
Marc Escribà-Gelonch
Herewith a new process concept for synthesis is presented which combines both UV-photoirradiation and high-p,T intensification (photo-high-p,T) in continuous flow. The application of this procedure to Vitamin D3 synthesis promotes thermal s...
Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent [0.03%]
茚二聚体PH46A的新潜在抗炎剂的立体选择性合成研究
Graham R Cumming,Tao Zhang,Gaia Scalabrino et al.
Graham R Cumming et al.
PH46A, belonging to a class of 1,2-Indane dimers, has been developed by our research group as a potential therapeutic agent for the treatment of inflammatory and autoimmune diseases. The initial synthetic route to PH46A gave a low overall y...
Process Safety Assessment of the Iron-Catalyzed Direct Olefin Diazidation for the Expedient Synthesis of Vicinal Primary Diamines [0.03%]
铁催化直接烯烃叠氮化合成 vicinal 叔 diamine 的工艺安全评估
Hai-Tao Zhu,Luca Arosio,Roberto Villa et al.
Hai-Tao Zhu et al.
We report herein a process safety assessment of the iron-catalyzed direct olefin diazidation for the preparation of a broad range of synthetically valuable vicinal primary diamines. Differential scanning calorimetry analysis of the correspo...
Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory [0.03%]
连续流旋涡反应器光氧化过程的研究——利用实验室空气作为氧化剂的高效运行模式研究
Darren S Lee,Zacharias Amara,Charlotte A Clark et al.
Darren S Lee et al.
We report the construction and use of a vortex reactor which uses a rapidly rotating cylinder to generate Taylor vortices for continuous flow thermal and photochemical reactions. The reactor is designed to operate under conditions required ...
Practical Synthesis of the Bicyclic Darunavir Side Chain: (3 R,3a S,6a R)-Hexahydrofuro[2,3- b]furan-3-ol from Monopotassium Isocitrate [0.03%]
实用的 bicyclic darunavir 侧链(3r,3aS,6aR)-六氢呋喃并[2,3-b]呋喃-3-醇由一钾异柠檬酸盐合成
Gary L Moore,Rodger W Stringham,David S Teager et al.
Gary L Moore et al.
A practical synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol-a key intermediate in the synthesis of darunavir-from monopotassium isocitrate is described. The isocitric acid salt, obtained from a high-yielding fermentation fed by sun...
Development of a Scalable Process for the Synthesis of DNDI-VL-2098: A Potential Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis [0.03%]
DNDI-VL-2098合成工艺的开发：一种潜在的治疗内脏利什曼病临床前药物候选物
Vijay S Satam,Srinivasa Rao Pedada,Pasumpon Kamaraj et al.
Vijay S Satam et al.
A process suitable for kilogram-scale synthesis of (2R)-2-methyl-6-nitro-2-{[4-(trifluoromethoxy)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole (DNDI-VL-2098, 2), a preclinical drug candidate for the treatment of visceral leishmanias...
Saikat Roy,Brianna Chamberlin,Adam J Matzger
Saikat Roy
Characterization of crystalline polymorphs and their quantitation has become an integral part of the pre-clinical drug development process. Raman spectroscopy is a powerful technique for the rapid identification of phases of pharmaceuticals...