Crystallization-Induced Diastereoisomer Transformation of Dihydroartemisinic Aldehyde with the Betti Base [0.03%]
结晶诱导的倍他碱和双氢青蒿醛的非对映异构体转化
Andrea Zanetti,Pauline Chaumont-Olive,Geoffrey Schwertz et al.
Andrea Zanetti et al.
Artemisinin is an important drug to fight malaria. It is produced either by extraction or via a semisynthetic route involving enzyme engineering. A key intermediate to produce artemisinin by the enzymatic route is dihydroartemisinic aldehyd...
Developing a Batch Isolation Procedure and Running It in an Automated Semicontinuous Unit: AWL CFD25 Case Study [0.03%]
批量隔离程序的开发及在自动化半连续装置中的应用——AWL CFD25案例研究
Sara Ottoboni,Muhid Shahid,Christopher Steven et al.
Sara Ottoboni et al.
A key challenge during the transition from laboratory/small batch to continuous manufacturing is the development of a process strategy that can easily be adopted for a larger batch/continuous process. Industrial practice is to develop the i...
Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents [0.03%]
偶氮化合物和偶氮试剂的热稳定性和爆炸危险评估
Sebastian P Green,Katherine M Wheelhouse,Andrew D Payne et al.
Sebastian P Green et al.
Despite their wide use in academia as metal-carbene precursors, diazo compounds are often avoided in industry owing to concerns over their instability, exothermic decomposition, and potential explosive behavior. The stability of sulfonyl az...
Daniel Jespersen,Brockton Keen,Jon I Day et al.
Daniel Jespersen et al.
Despite the exponential growth of the field of photocatalysis, for reasons that are not entirely clear, these precious photocatalysts are often used in the literature at loadings that exceed their maximum solubility. On an industrial scale,...
Solubility of Iridium and Ruthenium Organometallic Photoredox Catalysts [0.03%]
金属有机光氧化还原催化剂的溶解度：铱和钌物种
Daniel Jespersen,Brockton Keen,Jon I Day et al.
Daniel Jespersen et al.
Despite the exponential growth of the field of photocatalysis, for reasons that are not entirely clear, these precious photocatalysts are often used in the literature at loadings that exceed their maximum solubility. On an industrial scale,...
A Holistic Approach to Streamlining Pharmaceutical Processes: A Conversation [0.03%]
化繁为简：全方位提升药物研发及生产效率研讨会
B Frank Gupton,D Tyler McQuade
B Frank Gupton
Nearly 10 years ago, Frank Gupton and I had a chance encounter where we learned that we both had interest in creating efficient routes to generic medicines. Lucky for me, Frank and I began mentoring each other-Frank teaching me wisdom gaine...
Efficient Electrocatalytic Reduction of Furfural to Furfuryl Alcohol in a Microchannel Flow Reactor [0.03%]
微通道流动反应器中糠醛高效电催化还原制备糠醇
Yiran Cao,Timothy Noël
Yiran Cao
Furfural is considered to be an essential biobased platform molecule. Recently, its electrocatalytic hydrogenation is regarded as a more environmentally friendly process compared to traditional catalytic hydrogenation. In this study, a new,...
Parallel, Large-Scale, and Long Synthetic Oligodeoxynucleotide Purification Using the Catching Full-Length Sequence by Polymerization Technique [0.03%]
利用聚合方法捕获全长序列技术进行平行、大规模和长链合成寡核苷酸纯化
Dhananjani N A M Eriyagama,Shahien Shahsavari,Bhaskar Halami et al.
Dhananjani N A M Eriyagama et al.
The catching by polymerization synthetic oligodeoxynucleotide (ODN) purification technique was shown to be potentially suitable for high throughput purification by purifying 12 ODNs simultaneously, to be convenient for large-scale purificat...
Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor [0.03%]
一种基于过氧化酸介导氧化在PFA管道反应器中连续生产硝基烷的方案
Sergey V Tsukanov,Martin D Johnson,Scott A May et al.
Sergey V Tsukanov et al.
The synthetic utility of the aza-Henry reaction can be diminished on scale by potential hazards associated with the use of peracid to prepare nitroalkane substrates, and the nitroalkanes themselves. In response, a continuous and scalable ch...
Scalable Synthesis and Purification of Acetylated Phosphatidyl Choline Headgroup [0.03%]
可扩展合成和脱乙酰化磷脂胆碱极性头组的纯化技术
Rajesh Subramaniam,Ramesh Jagadeesan,Iswarya Mathew et al.
Rajesh Subramaniam et al.
The acetylated headgroup of the most abundant mammalian phospholipid, 1,2-diacetyl-3-sn-phosphatidyl choline (DAcPC), has several important applications in research. For instance, it can be dissolved in the same amount of water as in the fl...