Promiscuous partitioning of a covalent intermediate common in the pentein superfamily [0.03%]
潘肽素超家族中常见的共价中间体的异禀分区现象
Thomas W Linsky,Arthur F Monzingo,Everett M Stone et al.
Thomas W Linsky et al.
Many enzymes in the pentein superfamily use a transient covalent intermediate in their catalytic mechanisms. Here we trap and determine the structure of a stable covalent adduct that mimics this intermediate using a mutant dimethylarginine ...
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions [0.03%]
通过阻断polo框结构域依赖的蛋白质相互作用抑制极光样蛋白激酶1
Wolfgang Reindl,Juping Yuan,Andrea Krämer et al.
Wolfgang Reindl et al.
The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients. Plk1 localizes to its intracellular anchoring sites via its ...
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions [0.03%]
通过阻断Polo框结构域依赖的蛋白质相互作用抑制 Polo 样激酶 1
Wolfgang Reindl,Juping Yuan,Andrea Krämer et al.
Wolfgang Reindl et al.
The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients. Plk1 localizes to its intracellular anchoring sites via its ...
Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin [0.03%]
硫酯酶催化纳香素生物合成中寡聚醚链的释放机制研究
Tiangang Liu,Xin Lin,Xiufen Zhou et al.
Tiangang Liu et al.
The polyketide backbone of the polyether ionophore antibiotic nanchangmycin (1) is assembled by a modular polyketide synthase in Streptomyces nanchangensis NS3226. The ACP-bound polyketide is thought to undergo a cascade of oxidative cycliz...
Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin [0.03%]
硫酯酶介导的硫酯键水解反应机制及其在南召霉素生物合成中的作用研究
Tiangang Liu,Xin Lin,Xiufen Zhou et al.
Tiangang Liu et al.
The polyketide backbone of the polyether ionophore antibiotic nanchangmycin (1) is assembled by a modular polyketide synthase in Streptomyces nanchangensis NS3226. The ACP-bound polyketide is thought to undergo a cascade of oxidative cycliz...
Peptidoglycan and muropeptides from pathogens Agrobacterium and Xanthomonas elicit plant innate immunity: structure and activity [0.03%]
病原体农杆菌和黄单胞菌的肽聚糖和Mur佩ptide：结构和活性激发植物先天免疫反应
Gitte Erbs,Alba Silipo,Shazia Aslam et al.
Gitte Erbs et al.
Peptidoglycan (PGN) is a unique and essential structural part of the bacterial cell wall. PGNs from two contrasting Gram-negative plant pathogenic bacteria elicited components characteristic of the innate immune system in Arabidopsis thalia...
Peptidoglycan and muropeptides from pathogens Agrobacterium and Xanthomonas elicit plant innate immunity: structure and activity [0.03%]
病原体冠瘿菌和黄单胞菌的肽聚糖和穆拉肽引起植物先天免疫：结构与活性关系
Gitte Erbs,Alba Silipo,Shazia Aslam et al.
Gitte Erbs et al.
Peptidoglycan (PGN) is a unique and essential structural part of the bacterial cell wall. PGNs from two contrasting Gram-negative plant pathogenic bacteria elicited components characteristic of the innate immune system in Arabidopsis thalia...
Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms [0.03%]
基于微滴的微流控平台在哺乳动物细胞和多细胞生物体的包裹及筛选中的应用
Jenifer Clausell-Tormos,Diana Lieber,Jean-Christophe Baret et al.
Jenifer Clausell-Tormos et al.
High-throughput, cell-based assays require small sample volumes to reduce assay costs and to allow for rapid sample manipulation. However, further miniaturization of conventional microtiter plate technology is problematic due to evaporation...
Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms [0.03%]
基于微滴的微流控平台在哺乳动物细胞和多细胞生物体的包裹及筛选中的应用
Jenifer Clausell-Tormos,Diana Lieber,Jean-Christophe Baret et al.
Jenifer Clausell-Tormos et al.
High-throughput, cell-based assays require small sample volumes to reduce assay costs and to allow for rapid sample manipulation. However, further miniaturization of conventional microtiter plate technology is problematic due to evaporation...
Reinhard Sterner,Rainer Merkl,Frank M Raushel
Reinhard Sterner
The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving f...