Peter Leadlay
Peter Leadlay
Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags [0.03%]
六组氨酸标签与血红素配位介导的乙型肝炎病毒衣壳多价展示
Duane E Prasuhn Jr,Jane Kuzelka,Erica Strable et al.
Duane E Prasuhn Jr et al.
The addition of a hexahistidine tag to the N terminus of the hepatitis B capsid protein gives rise to a self-assembled particle with 80 sites of high local density of histidine side chains. Iron protoporphyrin IX has been found to bind tigh...
Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags [0.03%]
六组氨酸标签与乙肝病毒核心蛋白的配位介导血红素多价展示
Duane E Prasuhn Jr,Jane Kuzelka,Erica Strable et al.
Duane E Prasuhn Jr et al.
The addition of a hexahistidine tag to the N terminus of the hepatitis B capsid protein gives rise to a self-assembled particle with 80 sites of high local density of histidine side chains. Iron protoporphyrin IX has been found to bind tigh...
Proteasome inhibition by fellutamide B induces nerve growth factor synthesis [0.03%]
脯硫胺B通过抑制蛋白酶体诱导神经生长因子合成
John Hines,Michael Groll,Margaret Fahnestock et al.
John Hines et al.
Neurotrophic small molecules have the potential to aid in the treatment of neuronal injury and neurodegenerative diseases. The natural product fellutamide B, originally isolated from Penicillium fellutanum, potently induces nerve growth fac...
Proteasome inhibition by fellutamide B induces nerve growth factor synthesis [0.03%]
fk替丁B通过抑制蛋白酶体诱导神经生长因子合成
John Hines,Michael Groll,Margaret Fahnestock et al.
John Hines et al.
Neurotrophic small molecules have the potential to aid in the treatment of neuronal injury and neurodegenerative diseases. The natural product fellutamide B, originally isolated from Penicillium fellutanum, potently induces nerve growth fac...
An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction [0.03%]
核糖体肽基转移反应过渡态中未带电的胺
David A Kingery,Emmanuel Pfund,Rebecca M Voorhees et al.
David A Kingery et al.
The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To understand how RNA promotes this reaction requires a detailed understanding of the chemical transition state. Here, we report the Brønsted coefficie...
An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction [0.03%]
核糖体肽基转移反应过渡态中未带电的胺
David A Kingery,Emmanuel Pfund,Rebecca M Voorhees et al.
David A Kingery et al.
The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To understand how RNA promotes this reaction requires a detailed understanding of the chemical transition state. Here, we report the Brønsted coefficie...
The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function [0.03%]
Cep15在氯棘霉素生物合成中的作用：祖先催化功能的重新激活
Andrew W Truman,Qingzhi Fan,Marlene Röttgen et al.
Andrew W Truman et al.
The gene clusters of several glycopeptides contain genes that encode COG2120 domain zinc-dependent N-acetylglucosaminyl deacetylases. Recently, a COG2120 protein encoded in the chloroeremomycin gene cluster, Cep15, has been postulated to po...
The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function [0.03%]
Cep15在氯棘霉素生物合成中的作用：激活祖先催化功能的作用
Andrew W Truman,Qingzhi Fan,Marlene Röttgen et al.
Andrew W Truman et al.
The gene clusters of several glycopeptides contain genes that encode COG2120 domain zinc-dependent N-acetylglucosaminyl deacetylases. Recently, a COG2120 protein encoded in the chloroeremomycin gene cluster, Cep15, has been postulated to po...
Promiscuous partitioning of a covalent intermediate common in the pentein superfamily [0.03%]
潘肽素超家族中普适的共价中间体的多产分割现象
Thomas W Linsky,Arthur F Monzingo,Everett M Stone et al.
Thomas W Linsky et al.
Many enzymes in the pentein superfamily use a transient covalent intermediate in their catalytic mechanisms. Here we trap and determine the structure of a stable covalent adduct that mimics this intermediate using a mutant dimethylarginine ...