Design of peptide inhibitors for the importin alpha/beta nuclear import pathway by activity-based profiling [0.03%]
基于活性的分析方法设计阻断进口蛋白α/β核输入途径的肽抑制剂
Shunichi Kosugi,Masako Hasebe,Tetsuyuki Entani et al.
Shunichi Kosugi et al.
Despite the current availability of selective inhibitors for the classical nuclear export pathway, no inhibitor for the classical nuclear import pathway has been developed. Here we describe the development of specific inhibitors for the imp...
Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones [0.03%]
结核分枝杆菌基因敲除导致细胞壁类麦角酸衍生物积累及酮体聚集的机制研究
Apoorva Bhatt,Alistair K Brown,Albel Singh et al.
Apoorva Bhatt et al.
Mycolic acids are essential components of the mycobacterial cell wall. In this study, we show that a gene encoding a reductase involved in the final step of mycolic acid biosynthesis can be deleted in Mycobacterium smegmatis without affecti...
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design [0.03%]
白三烯A4水解酶活性位点的结构分析及其对M1氨基肽酶和抑制剂设计的意义
Fredrik Tholander,Ayumo Muroya,Bernard-Pierre Roques et al.
Fredrik Tholander et al.
M1 aminopeptidases comprise a large family of biologically important zinc enzymes. We show that peptide turnover by the M1 prototype, leukotriene A4 hydrolase/aminopeptidase, involves a shift in substrate position associated with exchange o...
Yiqun Deng,Jie Liu,Qi Zheng et al.
Yiqun Deng et al.
Protein-protein interactions play an essential role in the assembly of the macromolecular complexes that form functional networks and control cellular behavior. Elucidating principles of molecular recognition governing potentially complex i...
Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana [0.03%]
芽孢杆菌病原真菌白僵菌中环状寡聚肽并氨基酸化合物 beauvericin 的生物合成
Yuquan Xu,Rousel Orozco,E M Kithsiri Wijeratne et al.
Yuquan Xu et al.
Beauvericin, a cyclohexadepsipeptide ionophore from the entomopathogen Beauveria bassiana, shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic (cell motility inhibitory) activity in vitro. The b...
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN) [0.03%]
人类共生菌拟杆菌合成2-酮-3-脱氧-D-甘油-D-半乳糖非酸(KDN)
Liangbing Wang,Zhibing Lu,Karen N Allen et al.
Liangbing Wang et al.
The proper functioning of the human intestine is dependent on its bacterial symbionts, the most predominant of which belong to the Phylum Bacteroidetes. These bacteria are known to use variable displays of multiple capsular polysaccharides ...
Joseph Zaia
Joseph Zaia
The biological significance of protein and lipid glycosylation is well established. For example, cells respond to environmental stimuli by altering glycan structures on their surfaces, and cancer cells evade normal growth regulation in part...
Friend or foe? Turning a host defense protein into a pathogen's accomplice [0.03%]
敌友难辨？宿主防御蛋白如何反客为主助力病原体入侵
Aimee Shen,Matthew Bogyo
Aimee Shen
Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus ...
Double whammy: bispecific antibodies help immune cells attack tumors [0.03%]
双管齐下：双特异性抗体助T细胞识别并杀伤肿瘤细胞
Chandra Shekhar
Chandra Shekhar
Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins [0.03%]
胺类N-糖基化酶Asm25参与阿斯米菌素的生物合成
Peiji Zhao,Linquan Bai,Juan Ma et al.
Peiji Zhao et al.
Ansamitocins are potent antitumor maytansinoids produced by Actinosynnema pretiosum. Their biosynthesis involves the initial assembly of a macrolactam polyketide, followed by a series of postpolyketide synthase (PKS) modifications. Three an...