Reinhard Sterner,Rainer Merkl,Frank M Raushel
Reinhard Sterner
The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving f...
Alexei F Kisselev
Alexei F Kisselev
An article in this issue of Chemistry & Biology (Hines et al., 2008) and a recent study in Nature (Groll et al., 2008) establish three natural products as novel proteasome inhibitors. These inhibitors, discovered in an unusual way, reveal a...
Alexei F Kisselev
Alexei F Kisselev
An article in this issue of Chemistry & Biology (Hines et al., 2008) and a recent study in Nature (Groll et al., 2008) establish three natural products as novel proteasome inhibitors. These inhibitors, discovered in an unusual way, reveal a...
Markus Pech,Knud H Nierhaus
Markus Pech
In this issue of Chemistry & Biology, Lang et al. (2008) add an important step toward a molecular understanding of ribosomal peptide-bond formation: they unravel the involvement of an essential partner of the reaction, namely the 2'-OH grou...
Markus Pech,Knud H Nierhaus
Markus Pech
In this issue of Chemistry & Biology, Lang et al. (2008) add an important step toward a molecular understanding of ribosomal peptide-bond formation: they unravel the involvement of an essential partner of the reaction, namely the 2'-OH grou...
Kyung S Lee,Jeffrey R Idle
Kyung S Lee
Polo-like kinase 1 (Plk1) appears to be an attractive target for anticancer therapy. In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with th...
Kyung S Lee,Jeffrey R Idle
Kyung S Lee
Polo-like kinase 1 (Plk1) appears to be an attractive target for anticancer therapy. In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with th...
In silico pharmacology: computer-aided methods could transform drug development [0.03%]
计算药理学：计算机辅助方法或将改变药物开发模式
Chandra Shekhar
Chandra Shekhar
In silico pharmacology: computer-aided methods could transform drug development [0.03%]
计算药理学：计算机辅助方法或将改变药物开发模式
Chandra Shekhar
Chandra Shekhar
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis [0.03%]
基于原子定点突变技术揭示23S核糖体RNA的A2451残基在肽键合成中的功能作用
Kathrin Lang,Matthias Erlacher,Daniel N Wilson et al.
Kathrin Lang et al.
Peptide bond formation is a fundamental reaction in biology, catalyzed by the ribosomal peptidyl-transferase ribozyme. Although all active-site 23S ribosomal RNA nucleotides are universally conserved, atomic mutagenesis suggests that these ...