Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity [0.03%]
用双琥珀酸辛二酯和癸二酸修饰氧合血红蛋白的分子内交联：产生氧气亲合力降低的交联血红蛋白
B N Manjula,P K Smith,A Malavalli et al.
B N Manjula et al.
The sulfosuccinimidyl esters of suberic and sebacic acids readily introduce intramolecular crosslinks into oxy HbA at pH 7.4, the relative efficiency of crosslinking by the suberate ester being slightly higher than that of sebacate. Nearly ...
H W Kim,A G Greenburg
H W Kim
To define hemoglobin-based oxygen carrier (HBOC) vasoactivity, a preliminary study with isolated vascular ring preparations was performed. Transverse ring segments of pulmonary artery and aorta were obtained from male SD rats, mounted in a ...
The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium [0.03%]
α-α交联血红蛋白的自动氧化及其在内皮细胞氧化应激中的可能作用
R Motterlini,R Foresti,K Vandegriff et al.
R Motterlini et al.
The aim of the present study was to investigate the role of hemoglobin autoxidation in the induction of endothelial heme oxygenase (HO), an inducible "stress" protein which is responsible for heme catabolism. Porcine aortic endothelial cell...
Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin [0.03%]
莱特曼信函中修改的血红蛋白研究综述：试图阐明无细胞四聚体血红蛋白的毒性问题
J R Hess
J R Hess
In the final two years, June 1991 to June 1993, of the Letterman Army Institute of Research, a variety of cell, tissue, organ, and animal systems were used to explore the toxicities of model hemoglobin (Hb) solutions produced in the sterile...
Nitrosyl hemoglobin formation in-vivo after intravenous administration of a hemoglobin-based oxygen carrier in endotoxemic rats [0.03%]
内毒素血症大鼠静脉注射含氮氧基血红蛋白的血液代用品后的体内肌红蛋白形成
A G Greenburg,H W Kim
A G Greenburg
Role of nitric oxide scavenging in peripheral vasoconstrictor response to beta beta cross-linked hemoglobin [0.03%]
硝酸盐清除在β-交联血红蛋白诱发外周血管收缩中的作用研究
J A Ulatowski,R C Koehler,T Nishikawa et al.
J A Ulatowski et al.
Transfusion with many crosslinked hemoglobin solutions causes an increase in arterial pressure that may be mediated by scavenging of nitric oxide (NO). If so, we postulated that inhibiting synthesis of NO after hemoglobin transfusion would ...