Development of zero-link polymers of hemoglobin, which do not extravasate and do not induce pressure increases upon infusion [0.03%]
用于治疗的不渗出且输注后不会产生压力的血红蛋白零连接聚合物的开发
Enrico Bucci,Herman Kwansa,Raymond C Koehler et al.
Enrico Bucci et al.
Intramolecular crosslink of hemoglobin tetramers solved the problem of urine elimination and short intravascular retention time of cell free hemoglobin infusion. It also produced a family of crosslinked hemoglobins with P50 between 18 and 3...
Characterization of poly(ethylene glycol)-modified bovine hemoglobin by capillary zone electrophoresis [0.03%]
毛细管电泳表征聚乙二醇修饰的牛血红蛋白
Xian-Zhong Li,Qin-Hong Yang,Jiu-Feng Yan et al.
Xian-Zhong Li et al.
In this study capillary zone electrophoresis (CZE) was used to analyze the poly(ethylene glycol)-modified bovine hemoglobin(PEG-bHb). The results show that CZE separated the subunit of bovine hemoglobin based on the number of PEG conjugatin...
Effects of the resuscitation fluid and the hemoglobin based oxygen carrier (HBOC) excipient on the toxicity of the HBOC: Ringer's D,L-lactate, Ringer's L-lactate, and Ringer's ketone solutions [0.03%]
不同复苏液及血液代用品输注对血管内血红蛋白携氧载体毒性的缓解作用：林格氏D，L-乳酸溶液、林格氏L-乳酸溶液和酮体溶液的比较研究
C Robert Valeri,Gina Ragno,Richard L Veech
C Robert Valeri
Hemoglobin based oxygen carriers (HBOC) are resuspended in "excipients" consisting of Ringer's D,L-lactate containing antioxidants to prevent methemoglobin formation during storage. Investigators have reported cardiac arrhythmias following ...
Genomics and blood substitutes for 21st century Europe ("EuroBloodSubstitutes") [0.03%]
21世纪欧洲的基因组学和血液替代品("EuroBloodSubstitutes")
Kenneth C Lowe
Kenneth C Lowe
Blood transfusion is a medical intervention practised throughout the world. Blood is a biologically active material that can transmit diseases (e.g., HIV/AIDS and, perhaps, vCJD). People are becoming increasingly concerned about blood safet...
Eishun Tsuchida,Hiromi Sakai,Hirohisa Horinouchi et al.
Eishun Tsuchida et al.
Phospholipid vesicles or liposomes encapsulating purified and concentrated human hemoglobin (Hb-vesicle, HbV) have been developed as a transfusion alternative. They are void of blood-type antigens and infectious viruses; they are stable and...
Jean G Riess
Jean G Riess
The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as oxygen delivery systems are briefly reviewed. The key issues related to the selection of an appropriate, readily excretable PFC and the engineering o...
Evolution of artificial cells using nanobiotechnology of hemoglobin based RBC blood substitute as an example [0.03%]
以基于纳米生物技术的血红蛋白人工血液为例的人工细胞进化研究
Thomas Ming Swi Chang
Thomas Ming Swi Chang
The original artificial red blood cells have evolved into oxygen carriers in the form of polyhemoglobin and conjugated hemoglobin. Clinical conditions requiring only oxygen carriers are responding well to these types of oxygen carriers with...
Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others [0.03%]
面向二十一世纪的血液成分代用制剂：人工氧载体、血小板替代品、重组凝血因子及其他
Hae Won Kim,A Gerson Greenburg
Hae Won Kim
In this brief overview, recent progress and current status of blood substitute research and development is summarized. Current blood substitute development efforts are focused on red blood cell substitutes but substitutes for platelets and ...
Emine Karakuş,Sule Pekyardimci,Esma Kiliç
Emine Karakuş
New ammonium-selective membrane electrode based on poly(vinyl chloride) (PVC) membrane containing palmitic acid (a long-chain fatty acid) and nonactin as an ammonium ionophore for the determination of ammonium ions in the 10(-7) - 10(-1) mo...
Bioenergy beads: a tool for regeneration of ATP/NTP in biocatalytic synthesis [0.03%]
生物能源珠：生物催化合成中再生ATP/NTP的工具
Jozef Nahálka,Peter Gemeiner,Marek Bucko et al.
Jozef Nahálka et al.
Active inclusion bodies of recombinant polyphosphate kinase were obtained by simple washing of Escherichia coli cells with nonionic detergent and then they were immobilized in agar/TiO2 beads. Bioenergy beads obtained are charged by polypho...