Arthur P Bode,Thomas H Fischer
Arthur P Bode
Starting with the work of Klein et al. in the early 1950s, there has been a concerted effort to apply the process of freeze-drying for the preservation of platelets in order to provide hemorrhagic patients with a stable infusible hemostatic...
Frédéric Gerber,Gilles Waton,Marie Pierre Krafft et al.
Frédéric Gerber et al.
Exceptionally long lived microbubbles containing a fluorocarbon as part of their filling gas have been obtained by using a fluorinated phospholipid instead of a standard phospholipid as shell component. An unexpected, strong synergistic eff...
Thiolation mediated pegylation platform to generate functional universal red blood cells [0.03%]
一种用于生成具有功能的通用型红细胞的硫醇介导的聚乙二醇化平台
Parimala Nacharaju,Belur N Manjula,Seetharama A Acharya
Parimala Nacharaju
The PEGylation that adds an extension arm on protein amino groups with the conservation of their positive charge masks the A and D antigens of erythrocytes efficiently. In the present study, the efficiency of masking the antigens of RBC by ...
Expectations and implications of blood sparing with hemoglobin based oxygen carriers [0.03%]
携氧型血红蛋白制品的期许及影响：减少输血不可缺少的新血液制品？
T N Estep
T N Estep
To gain insight into the degree to which hemoglobin based oxygen carriers may replace the need for transfusion in surgical patients experiencing blood loss, a simple mathematical model was developed. This model predicts the amount of blood ...
One-year observation of Wistar rats after intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers) [0.03%]
韦斯特大鼠静脉输注氧合器(人造携氧者)-血红蛋白囊泡(HBV)后一年的观察研究
Hiromi Sakai,Eishun Tsuchida,Hirohisa Horinouchi et al.
Hiromi Sakai et al.
Hemoglobin-vesicles (HbV) or liposome-encapsulated Hb are artificial oxygen carriers. Our previous studies of the bolus infusion of HbV into Wistar rats showed that HbV was captured by the reticuloendothelial system from the blood stream an...
Trapping hemoglobin in rigid matrices: fine tuning of oxygen binding properties by modulation of encapsulation protocols [0.03%]
利用刚性基质捕获血红蛋白并通过调节包封条件来微调其携氧性能
Stefano Bruno,Luca Ronda,Stefano Bettati et al.
Stefano Bruno et al.
Encapsulation of hemoglobin in a biocompatible matrix is a potential strategy for obtaining blood substitutes. Such a system would retain most of the immunogenic and functional properties of the physiologically relevant oxygen carrier but w...
Acellular invertebrate hemoglobins as model therapeutic oxygen carriers: unique redox potentials [0.03%]
无细胞无脊椎动物血红蛋白作为治疗性氧气载体模型的独特氧化还原电位
John P Harrington,Shiho Kobayashi,Scott C Dorman et al.
John P Harrington et al.
Natural acellular polymeric hemoglobins (Hb) provide oxygen transport and delivery within many terrestrial and marine invertebrate organisms. It has been our premise that these natural acellular Hbs may serve as models of therapeutic hemogl...
Clara Fronticelli,Raymond C Koehler,William S Brinigar
Clara Fronticelli
This paper describes the approaches we have taken to construct a) mutant hemoglobins with different oxygen affinities, and b) mutant hemoglobins and myoglobins that polymerize to high molecular weight aggregates in an effort to prevent extr...
Synthesis of a hemoglobin polymer containing antioxidant enzymes using complementary chemistry of maleimides and sulfhydryls [0.03%]
利用马来酰亚胺和巯基的互补化学合成含抗氧化酶的血红蛋白聚合物
Eugene Tarasov,Melanie M Blaszak,Jacqueline M LaMarre et al.
Eugene Tarasov et al.
To increase the overall size of hemoglobin (Hb), we developed a novel system of polymerization based on the complementary chemistry between sulfhydryls and maleimides. The maleimides were introduced onto the protein through N-(-maleimidobut...
Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb] [0.03%]
非高血压六聚体sp-peg5000-hbo2分子特性研究
Dongxia Li,Belur N Manjula,Nancy T Ho et al.
Dongxia Li et al.
The development of hexaPEGylated Hb, (SP-PEG5K)(6)-Hb, using the newly designed thiolation-mediated maleimide chemistry based PEGylation, has validated the concept that engineering 'plasma volume expander' -like properties to Hb neutralizes...