Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines [0.03%]
新型（4-氯和4-酰氧基-2-丁炔基）噻基奎宁环的合成及其体外抗增殖活性研究
Stanisław Boryczka,Wojciech Mól,Magdalena Milczarek et al.
Stanisław Boryczka et al.
The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCR...
Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies [0.03%]
基于QSAR研究的抗肿瘤吖啶酮衍生物与DNA的物理化学作用
Marcin Koba,Tomasz Bączek
Marcin Koba
The acridinone derivatives with antitumor activity and ability with respect to noncovalent DNA binding were investigated for their quantitative structure-activity relationships (QSAR). Multiple regression analysis was used to model relation...
Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists [0.03%]
β₁-,β₂-和β₃-肾上腺素受体激动剂的比较三维定量结构活性关系研究
P Senthil Kumar,Prasad V Bharatam
P Senthil Kumar
A quantitative structure-activity relationship study of tryptamine-based derivatives of β(1)-, β(2)-, and β(3)-adrenoceptor agonists was conducted using comparative molecular field analysis (CoMFA). Correlation coefficients (cross-valida...
The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus [0.03%]
Schiff碱对吸水链霉菌产抗生素的影响研究
Slavica B Ilić,Sandra S Konstantinović,Dragiša S Savić et al.
Slavica B Ilić et al.
A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicu...
Comparison of a new class of pyrrole containing benzodiazepine ligands to the pyrazoloquinolinones CGS 9896, 9895, and 8216 [0.03%]
一类新型含吡咯苯二氮杂类配体与吡唑并喹啉酮CGS 9896，9895和8216的比较研究
L T Schove,J J Perez,P A Maguire et al.
L T Schove et al.
Four pyrazoloquninolinone compounds, variations of known high affinity ligands for the GABA A/Benzodiazepine receptors (BDZRs), were synthesized and their affinities for BDZRs in cerebellum and spinal cord measured and compared to the paren...