Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery [0.03%]
基因组学如何帮助基于靶标的COVID-19药物发现
P Chellapandi,S Saranya
P Chellapandi
Coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a global health emergency and no clinically approved vaccines or antiviral drugs available to date. Intensive res...
Discovery of anti-influenza nucleoside triphosphates targeting the catalytic site of A/PR/8/34/H1N1 polymerase [0.03%]
靶向A/PR/8/34/H1N1聚合酶催化位点的抗流感核苷三磷酸的发现
Nataraj Sekhar Pagadala,Rakesh Bhat,Jagadeesh Kumar D et al.
Nataraj Sekhar Pagadala et al.
In an effort to develop potent anti-influenza drugs that inhibit the activity of influenza virus RNA-dependent RNA polymerase (IAV RdRp), a database of nucleoside triphosphates with ~800 molecules were docked with the homology model of IAV ...
Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity [0.03%]
类二恶英和非类二恶英PCBs对肝蛋白质组的差异调节及对饮食引起的非酒精性脂肪肝病严重程度的影响
Jian Jin,Banrida Wahlang,Hongxue Shi et al.
Jian Jin et al.
Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with metabolic disruption and non-alcoholic fatty liver disease (NAFLD). Based on their ability to activate the aryl hydrocarbon receptor (AhR), PCBs are subdivid...
Inducing Apoptosis through Upregulation of p53: Structure-Activity Exploration of Anthraquinone Analogs [0.03%]
通过上调p53诱导细胞凋亡：蒽醌类似物的结构-活性探索
Abiodun Anifowose,Ayodeji A Agbowuro,Ravi Tripathi et al.
Abiodun Anifowose et al.
We previously reported a series of p53-elevating anthraquinone compounds with considerable cytotoxicity for acute lymphatic leukemia (ALL) cells. To further develop this class of compounds, we examined the effect of a few key structural fea...
Rheostat positions: A new classification of protein positions relevant to pharmacogenomics [0.03%]
rheostat位点：与药物基因组学相关的蛋白质新分类位点
Aron W Fenton,Braelyn M Page,Arianna Spellman-Kruse et al.
Aron W Fenton et al.
To achieve the full potential of pharmacogenomics, one must accurately predict the functional out comes that arise from amino acid substitutions in proteins. Classically, researchers have focused on understanding the consequences of individ...
A conjugated mTOR/MEK bifunctional inhibitor as potential polypharmacological anticancer agent: the prototype compound discovery [0.03%]
一种潜在的多药理学抗癌剂共价mTOR/MEK双功能抑制剂：候选化合物发现
Qiangqiang Tao,Fang Fang,Jiaming Li et al.
Qiangqiang Tao et al.
mTOR/MEK bifunctional inhibitors have the potential to surmount the drug resistance aroused from cross talk between PI3K/Akt/mTOR (PAM) and Ras/MEK/ERK pathways. Herein, we report the discovery of a conjugated dual-targeted molecule, compou...
Design, synthesis, and screening of sulfonylurea-derived NLRP3 inflammasome inhibitors [0.03%]
磺酰脲衍生物NLRP3炎性小体抑制剂的设计、合成及筛选
Amol A Kulkarni,Ayyiliath M Sajith,Trevor T Duarte et al.
Amol A Kulkarni et al.
Inflammasomes are multiprotein assemblies that produce robust inflammatory responses upon stimulation with pathogen- and/or danger-associated molecular patterns. Uncontrolled inflammasome activation has been linked to the pathophysiology of...
Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2- c]pyrazol-4(1 H)-ones [0.03%]
吲哚并吡唑类化合物的合成、II型糖尿病抑制活性、抗菌评价及分子对接研究
Satbir Mor,Suchita Sindhu
Satbir Mor
We report a convenient and efficient synthesis of indeno[1,2-c]pyrazol-4(1H)-ones (4a‒o) by the reaction of a variety of 2-acyl-(1H)-indene-1,3(2H)-diones (1) and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles (2)...
Synthesis and biological evaluation of a new series of 1-aryl-3-[4-(pyridin-2-ylmethoxy)phenyl]urea derivatives as new anticancer agents [0.03%]
一类新的1芳基-3-[4-(2-吡啶甲氧基)苯基]脲衍生物的合成及其抗肿瘤活性研究
Jian Feng,Tai Li,Shishao Liang et al.
Jian Feng et al.
The diaryl ureas are very important fragments in medicinal chemistry. By means of computer-aided design, 1-aryl-3-[4-(pyridin-2-ylmethoxy)phenyl]urea derivatives were designed and synthesized, and evaluated for their antiproliferative activ...
Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction [0.03%]
通过抑制Keap1-Nrf2蛋白-蛋白相互作用激活Nrf2
Sumi Lee,Longqin Hu
Sumi Lee
Activation of the transcription factor Nrf2 via the Keap1-Nrf2-ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exa...