[Evolving treatment landscape of pediatric acute leukemia: integration and breakthroughs in immunotherapy and targeted therapy] [0.03%]
[儿童急性白血病治疗格局的变革：免疫和靶向治疗的整合与突破]
Fei-Qiu Wen,Hui-Rong Mai
Fei-Qiu Wen
In recent years, immunotherapy and targeted therapy are reshaping the therapeutic paradigm of pediatric acute leukemia, shifting it from a protocol-driven era toward a strategy-oriented era. The significance is not only in improving remissi...
[Guideline for allogeneic hematopoietic stem cell transplantation in the treatment of transfusion-dependent thalassemia in China (2026)] [0.03%]
中国输血依赖性地中海贫血allo-HSCT治疗指南（2023年版）
Committee of Thalassemia Prevention and Treatment, China Maternal and Child Health Association;Subspecialty Group of Hematology, Society of Pediatrics et al.
Committee of Thalassemia Prevention and Treatment et al.
A comprehensive retrieval, evaluation, selection, and integration of literature on allogeneic hematopoietic stem cell transplantation (allo-HSCT) for transfusion-dependent thalassemia (TDT) published over the past decade was conducted. For ...
[Current status and prospects of family financial toxicity in childhood malignancies] [0.03%]
[儿童恶性肿瘤家庭经济毒性的现状与前景]
Si-Ting Wu,Chun-Li Wang,Dong-Rong Shi
Si-Ting Wu
Childhood malignancies, as a serious threat to children's health, not only cause tremendous suffering to children but also impose a heavy economic burden on their families and have become a major global public health challenge. The financia...
[Gut-vascular axis in Kawasaki disease: short-chain fatty acid-mediated immune regulation and therapeutic targets] [0.03%]
川崎病肠血管轴的研究进展：短链脂肪酸介导的免疫调节及治疗靶点探讨
Shu-Dong Wang,Fang Liu
Shu-Dong Wang
Kawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis predominantly affecting small- and medium-sized arteries in children, and its etiology and pathogenesis remain unclear. Studies show that gut microbiota ...
[Recent advances in predicting the surgical timing for neonatal necrotizing enterocolitis] [0.03%]
[新生儿坏死性小肠结肠炎手术时机预测研究的新进展]
Hong-Li Zhai,Yi Tang
Hong-Li Zhai
Neonatal necrotizing enterocolitis (NEC) is a life-threatening acute gastrointestinal disorder in preterm infants, characterized by high morbidity and mortality. Approximately 20%-60% of infants with NEC require emergency surgical intervent...
[cGAS-STING signaling pathway in Kawasaki disease: mechanistic insights and advances in clinical applications] [0.03%]
[kawasaki病中的cGAS-STING信号通路：机制启示与临床应用进展]
Yu Liao,Ting-Ting Xiao
Yu Liao
Kawasaki disease (KD) is an acute systemic immune‑mediated vasculitis that can lead to coronary artery lesions. Its etiology remains unclear and may involve immune responses, inflammatory reactions, and vascular endothelial injury mediated...
[Adeno-associated virus-mediated gene therapy for genetic epilepsy: prospects and challenges] [0.03%]
遗传性癫痫的腺相关病毒介导基因治疗：前景与挑战
Bo Sun,Xiao-Le Wang,Jing Peng
Bo Sun
With the development and launch of anti-seizure medications, some genetic epilepsies have precision treatments; however, many patients remain drug-resistant, which severely affects quality of life and overall health. Advances in gene therap...
[A case report of Diets-Jongmans syndrome caused by a KDM3B gene variant] [0.03%]
[由KDM3B基因突变引起的Diets-Jongmans综合征病例报道]
Ke-Xin Shen,Yan-Jie Xiang,Jin Wang et al.
Ke-Xin Shen et al.
A 5-year-3-month-old boy presented with intellectual disability, autism spectrum disorder, short stature, long ears, large auricles, a broad nasal tip, a pointed chin, and cryptorchidism. Whole-exome sequencing revealed a de novo likely pat...
[A case of isolated myeloid sarcoma initially presenting as a mediastinal mass] [0.03%]
孤立性髓系肿瘤细胞初发表现为前纵膈肿物一例报告
Jing-Hui Yang,Qing-Mei Zhou,Xue-Rong Yin et al.
Jing-Hui Yang et al.
The patient was a 7-year-old boy admitted with facial edema. Ultrasound indicated moderate pericardial effusion and pleural effusion. Contrast-enhanced chest computed tomography showed indistinct mediastinal structures with mild-to-moderate...
Gui-Xian Pan,Qiu-Ping Yang,Xi-Mei Yang et al.
Gui-Xian Pan et al.
A 12-year-old boy presented with recurrent abdominal pain for more than 5 months and a perianal mass for 10 days. Gastrointestinal endoscopy revealed multiple ulcers in the terminal ileum and colon, and Crohn's disease was diagnosed based o...