Roshan Kumar Dubey,Bablu Kumar
Roshan Kumar Dubey
Traditional Chinese Medicine (TCM) represents a holistic approach to health and wellness that integrates ancient philosophies with diverse therapeutic modalities. Rooted in concepts of Yin-Yang balance, Qi (vital energy), and the Five Eleme...
Perspectives on Fecal Microbiota Transplantation: Uses and Modes of Administration [0.03%]
粪菌移植的现状及应用形式展望
Ruchi Tiwari,Anjali Paswan,Gaurav Tiwari et al.
Ruchi Tiwari et al.
Fecal microbiota Transplantation (FMT), often referred to as stool transplantation, fecal transfusion, and fecal bacteria therapy, is considered one of the most medical innovations of the 20th century. Fecal microbiota Transplantation entai...
Shubham Singh,Dharmendra Singh Rajput,Naveen Gupta et al.
Shubham Singh et al.
Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication throug...
Unlocking the Potential of Sotagliflozin in Diabetes Mellitus targeting SGLT 1 & SGLT 2: A Comprehensive Review [0.03%]
Sotagliflozin在糖尿病治疗中的潜力：针对SGLT 1及SGLT 2的全面回顾
Manoj Kumbhare,Siddhi Chandak,Arshad Shaikh et al.
Manoj Kumbhare et al.
Sotagliflozin, a novel dual inhibitor of sodium-glucose cotransporters 1 and 2 (SGLT1/2), represents a promising therapeutic advancement for managing diabetes mellitus. By inhibiting SGLT1 in the small intestine and SGLT2 in the kidneys, so...
Epigenetic Regulation in Neuroplasticity: Key to Understanding and Treating Neurological Diseases [0.03%]
表观遗传调控在神经可塑性中的作用：理解及治疗神经系统疾病的钥匙
Narkhede Minal,Wankhede Nilesh,Kamble Akanksha
Narkhede Minal
Epigenetic mechanisms-DNA methylation, histone modifications, and non-coding RNAs-integrate genetic programs with environmental cues to shape neural development, plasticity, and pathology. During neurogenesis, methylation patterns and histo...
Evaluation, Characterization of Antioxidant Activity for Novel Benzothiazole Derivatives [0.03%]
新型苯并噻唑衍生物的抗氧化活性评价及表征
Siddhi M Chandak,Manoj R Kumbhare
Siddhi M Chandak
The present study focuses on the design, synthesis, in-silico studies, characterization, and evaluation of the antidiabetic activity of nitrogen and sulphur-containing heterocyclic compounds, specifically benzothiazole derivatives (2a-2e). ...
Bioanalytical Method Development and Validation of Dapagliflozin in Human Plasma Using RP-HPLC Method [0.03%]
使用RP-HPLC法测定人类血浆中达格列净的生物分析方法开发与验证
Pravin Rangnath Dighe,Manoj Ramesh Kumbhare
Pravin Rangnath Dighe
Background: Dapagliflozin is used for controlling blood glucose levels in patients with type 2 diabetes. It is a sodium-glucose cotransporter 2 inhibitor, which enhances the elimination of blood glucose through the urine ...
Natural Flavonoids as Anticancer Agents: Targeting the HIF-1α Signaling Pathway [0.03%]
天然黄酮类化合物的抗肿瘤作用：靶向HIF-1α信号通路
Nirmala Shinde,Ashwini Satalkar,Sachin Bhosale et al.
Nirmala Shinde et al.
Background: The clinical effectiveness of wide range of currently available anticancer drugs is being reduced .HIF-1 alpha is essential for the reprogramming of cancer cells' metabolism,so cancer treatments include inhibi...
Targeting FLT3 Mutations in Acute Myeloid Leukemia: The Role of Quizartinib in Precision Medicine [0.03%]
急性髓系白血病FLT3突变的精准治疗-确左替尼的作用探讨
Manoj Kumbhare,Siddhi Chandak,Bhagwan Ide et al.
Manoj Kumbhare et al.
Acute Myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy that disproportionately affects older individuals. Among the various genetic alterations, FLT3 internal tendem duplication (FLT3-ITD) mutations are present i...
Mechanistic Insights and Emerging Applications of Nanogel-Based Topical Drug Delivery Systems [0.03%]
基于纳米凝胶的局部药物输送系统的机制见解和新兴应用
Manoj Kumbhare,Prajakta Shinde,Dhanashree Mohite et al.
Manoj Kumbhare et al.
Purpose: Nanogels (NGs) represent a new generation of nanoscale hydrogel particles with immense biomedical applications, especially drug delivery System (DDS). Nanogels (NGs) are soft and water-retentive materials that de...