Engineering Ophthalmic Nanoemulsion Platforms: Design Principles and Translational Applications in Ocular Drug Delivery [0.03%]
工程化眼科纳米乳液平台：设计原理及眼药递送转化应用原则
Vijay R Mahajan,Yuvraj P Kokane,Arshad S Shaikh et al.
Vijay R Mahajan et al.
Due to physiological constraints that negatively affect the efficiency of conventional ocular preparations, such as fast tear turnover, poor corneal penetration, as well as short in-precornereal resident times, ocular drug delivery has long...
Multifunctional Quantum Dots: A Review of Emerging Roles in Technology and Sustainability [0.03%]
多功能量子点：技术与可持续性新兴角色综述
Fiza Arif Shaikh,Pravin Rangnath Dighe,Manoj Ramesh Kumbhare
Fiza Arif Shaikh
Aim: The aim of this study is to highlight the emerging and advanced applications of quantum dots (QDs) beyond their conventional use, emphasizing their role in modern electronics, healthcare, energy systems, food safety,...
Sunvozertinib A Next-Generation EGFR Exon 20 Insertion Inhibitor Transforming NSCLC Therapy [0.03%]
下一代EGFR 20号外显子插入突变抑制剂苏沃雷生片将改变NSCLC治疗格局
Manoj Kumbhare,Dhiraj Gadekar,Siddhi Chandak et al.
Manoj Kumbhare et al.
Sunvozertinib (DZD9008) is an emerging next-generation, highly selective EGFR tyrosine kinase inhibitor (TKI) designed to target EGFR exon 20 insertion (Ex20ins) mutations, a subtype of non-small cell lung cancer (NSCLC) associated with poo...
Electromagnetic Modulation of Biological Systems: Emerging Perspectives in Bioelectronic Healing [0.03%]
电磁场对生物系统的作用：生物电子治疗的新视角
Akanksha M Kamble,Kiran Kashinath Shinde
Akanksha M Kamble
Bio electromedicine, a dynamic field at the intersection of biology and electromagnetism, has gained prominence in modern healthcare for its diverse applications. This comprehensive review examines the historical development, fundamentals, ...
In Silico Approaches in Benzimidazole Derivatives Research: Recent Insights [0.03%]
苯并咪唑衍生物研究中的计算机模拟方法近期进展
Pratiksha Narayan Sonwane,Manoj Ramesh Kumbhare
Pratiksha Narayan Sonwane
Benzimidazole remains a privileged heteroaromatic scaffold with broad therapeutic potential, spanning antimicrobial, anticancer, antitubercular, and antiviral domains. In recent years (2020-2025), computational methodologies have significan...
2-Aminobenzothiazole: A Privileged Scaffold for Tyrosine Kinase-Targeted Anticancer Agents [0.03%]
2-氨基苯并噻唑：一类针对靶向酪氨酸激酶的抗肿瘤药物的基本结构单元
Rani D Navle,Nirmala V Shinde,Arti S Raut et al.
Rani D Navle et al.
2-Aminobenzothiazole's planar structure and tendency to bind to a diverse set of oncogenic targets have made 2-aminobenzothiazole a highly sought heterocyclic in research for anticancer agents. In the past 10 years, intense research in medi...
Etrasimod: A Next-Generation S1P Receptor Modulator for Ulcerative Colitis - Mechanistic Insights and Clinical Progress [0.03%]
埃特拉西莫德：用于溃疡性结肠炎的下一代S1P受体调节剂-机制见解和临床进展
Manoj R Kumbhare,Arshad S Shaikh,Bhagwan R Ide et al.
Manoj R Kumbhare et al.
Etrasimod, a next-generation oral selective sphingosine-1-phosphate (S1P) receptor modulator, has emerged as a promising treatment for immune-mediated inflammatory diseases (IMIDs), most notably moderate-to-severe ulcerative colitis (UC). A...
Harsha Icharam Narkhede,Karan Jayantilal Jain,Ishita Sanjay Dalvi et al.
Harsha Icharam Narkhede et al.
Autophagy, a highly conserved catabolic process, plays a fundamental role in maintaining cellular homeostasis by degrading and recycling unnecessary or dysfunctional cellular components through lysosomal pathways. It serves as a vital mecha...
Substituted 2-Phenyl Imidazolidines: Synthetic Strategies, Biological Activities, Mechanistic Insights, and Nanocarrier-Based Advancements [0.03%]
取代的2-苯基咪唑烷类化合物：合成策略、生物活性、机理见解及纳米载体递送体系最新进展
Arti S Raut,Sachin K Bhosle,Rani D Navle et al.
Arti S Raut et al.
Substituted 2-phenyl imidazolidines present a structurally diversified family of heterocycles with several medicinal potentials. Their significance is due mostly to the presence of the phenyl group at the C-2 position, which enhances lipoph...
Thiazolidine-2,4-Dione: Bridging the Gap Between Synthesis, SAR, and Biological Activities, and Computational Predictions [0.03%]
噻唑烷二酮：连接合成、构效关系及生物活性和计算预测的桥梁
Nirmala V Shinde,Vrushali P Patole,Siddhi M Chandak
Nirmala V Shinde
Introduction: Thiazolidinedione is one of the most important classes in medicinal chemistry. Thiazolidine-2,4-dione (TZD) is a versatile scaffold, best known for its use in the development of anti-diabetic drugs such as p...