Dao-Hong Chen,Xiao-Shi Zhang
Dao-Hong Chen
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chem...
Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma [0.03%]
胰岛素样生长因子结合蛋白-3与食管鳞癌放射治疗反应和预后的相关性研究
Li-Ling Luo,Lei Zhao,Mian Xi et al.
Li-Ling Luo et al.
Background: Insulin-like growth factor-binding protein-3 (IGFBP-3) is suggested to predict the radiosensitivity and/or prognosis of patients with esophageal squamous cell carcinoma (ESCC). The present study was designed t...
Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma [0.03%]
单纯采用调整剂量的环磷酰胺、多柔比星、长春新碱和泼尼松化疗或联合利妥昔单抗诱导外周血干细胞动员治疗高危非霍奇金淋巴瘤
Yuankai Shi,Ping Zhou,Xiaohong Han et al.
Yuankai Shi et al.
Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is an efficient treatment of non-Hodgkin's lymphoma (NHL). This study aimed to assess the efficacy and toxicity of dose-adjust...
The updated incidences and mortalities of major cancers in China, 2011 [0.03%]
中国2011年主要癌症发病和死亡危险性再估计
Wanqing Chen,Rongshou Zheng,Hongmei Zeng et al.
Wanqing Chen et al.
Introduction: The National Central Cancer Registry (NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mortal...
Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment [0.03%]
多学科治疗后4期神经母细胞瘤儿童脑转移患者的研究
Jia Zhu,Juan Wang,Zi-Jun Zhen et al.
Jia Zhu et al.
Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neurobla...
The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study [0.03%]
头颈鳞癌中Tiam1蛋白表达的预后价值：回顾性研究
Hang Yang,Yu-Chen Cai,Ye Cao et al.
Hang Yang et al.
Introduction: Head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide and has a poor prognosis. A biomarker predicting the clinical outcome of HNSCC patients could be useful in guiding treatment plannin...
Sha He,Yi Lu,Xia Liu et al.
Sha He et al.
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumo...
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy [0.03%]
干细胞来源的外泌体：在基质重塑、肿瘤进展和癌症免疫治疗中的作用
Farah Fatima,Muhammad Nawaz
Farah Fatima
Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may...
Theo A Knijnenburg,Tycho Bismeijer,Lodewyk F A Wessels et al.
Theo A Knijnenburg et al.
Background: A central challenge in cancer research is to create models that bridge the gap between the molecular level on which interventions can be designed and the cellular and tissue levels on which the disease phenoty...
miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis [0.03%]
microRNA-506通过抑制RAD51同源重组轴调控化疗敏感性
Guoyan Liu,Fengxia Xue,Wei Zhang
Guoyan Liu
Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progres...