Losartan potassium loaded sustained release matrix tablets: Influence of various hydrophilic and hydrophobic polymers on drug release behaviour [0.03%]
含 losartan 钾缓释矩阵片剂中各种亲水和疏水聚合物对药物释放行为的影响
D D Vohra,K S Pagi,K S Rajesh
D D Vohra
Losartan potassium is an angiotensin II receptor antagonist readily absorbed from the GIT, following oral administration. It has low bioavailability as it undergoes extensive first pass metabolism and low elimination half-life. The present ...
Formulation, evaluation and optimization of sustained release matrix tablets of captopril [0.03%]
卡托普利缓释矩阵片的处方、评价及优化研究
V Pandya Pandya,Vandana B Patel,Prajesh Patel
V Pandya Pandya
Sustained release matrix tablet is a delivery system by which the drug can be delivered at a controlled rate for long period of time. The present study aims at formulation, evaluation and optimization of captopril matrix tablets. A 3(2) ful...
Monali M Kapadia,S T Solanki,V Parmar et al.
Monali M Kapadia et al.
Spray formulation can minimize pain and irritation experience during the application of conventional dosage forms. Econazole Nitrate is an active ingredient of the aerosol concentrate to be used for twice-daily application because of its lo...
Formulation and evaluation of multiparticulate system for chronotherapeutic delivery of salbutamol sulphate [0.03%]
用于定时给药的硫酸沙丁胺醇多单元控释制剂的制备和评价
Pallavi M Chaudhari,Pravin D Chaudhari
Pallavi M Chaudhari
Solution layering technique was used to prepare pellets of Salbutamol Sulphate. A multiparticulate system was prepared with pH independent and pH dependent coatings, and evaluated as pulsatile drug delivery system. Salbutamol sulphate relea...
Development and characterization of microemulsion containing antihypertensive agent using factorial design [0.03%]
采用析因设计制备并表征含有降压药物的微乳体系
P Shah,D Swarnkar,R Parikh
P Shah
Microemulsion which act as a carrier for drug having poor water solubility, were formulated by the use of excipients having safety of administration and solubility of drug component. The phase study was carried out using isopropyl myristate...
Enhancement of dissolution of Telmisartan through use of solid dispersion technique - surface solid dispersion [0.03%]
利用表面固态分散技术增强telmisartan的溶解度研究
Bhumika Patel,R H Parikh,Deepali Swarnkar
Bhumika Patel
The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using Surface solid dispersion (SSD) made of polymers like Poloxamer 407, PEG 6000 by Solvent evaporation method. The drug was solubilize...
D Krishna Koradia,H Rajesh Parikh
D Krishna Koradia
Albendazole, a BCS class II drug, has poor dissolution characteristic. In order to enhance dissolution nanocrystals were prepared by antisolvent precipitation process using PVP K-30(0.05%,0.1%,0.2%,0.4%) as stabilizer. The process was optim...
Preparation and formulation of transferosomes containing an antifungal agent for transdermal delivery: Application of Plackett-Burman design to identify significant factors influencing vesicle size [0.03%]
负载抗真菌药物转移泡的制备与处方：应用Plackett-Burman设计筛选影响囊泡大小的重要因素
Rutu B Patel,R H Parikh
Rutu B Patel
Transferosomes containing an anti-fungal agent were prepared by Rotary Flask Evaporation -Sonication method. Eight batches were prepared in triplicate and vesicle size of each batch was determined. Plackett-Burman Design was employed to ide...
Physiologically activated phase transition systems for improved ocular retention of ketorolac tromethamine [0.03%]
一种可改善酮咯酸氨化钠眼部滞留的生理激活相变系统
Sunil Thakor,Imran Vhora,Jagruti Desai et al.
Sunil Thakor et al.
In present investigation, novel physiologically activated phase transition systems for Ketorolac Tromethamine was developed. In-situ gelling systems: pH sensitive gel using carbopol 980 and HPMC K100LV, ion sensitive gel using gallan gum an...
Effect of components (polymer, plasticizer and solvent) as a variable in fabrication of diclofenac transdermal patch [0.03%]
制备双氯芬酸透皮贴剂中变量成分(聚合物、增塑剂和溶剂)的影响研究
Chetna Modi
Chetna Modi
Transdermal drug delivery influence consumer acceptance and marked increase in bioavailability of some drugs which undergoes hepatic first-pass metabolism. Fabrication of transdermal patch requires lots of attention regarding the amount of ...