Frequency of mutations in Mediterranean fever gene, with gender and genotype-phenotype correlations in a Turkish population [0.03%]
土耳其人群中地中海发热基因突变频率的性别和基因型表型相关性研究
Salih Coşkun,Serkan Kurtgöz,Ece Keskin et al.
Salih Coşkun et al.
Familial Mediterranean fever (FMF) is the most common hereditary inflammatory periodic disease, characterized by recurrent episodes of fever, abdominal pain, synovitis and pleurisy. The aim of this study was to determine the frequency and d...
Statistical equivalent of the classical TDT for quantitative traits and multivariate phenotypes [0.03%]
定量性状和多态表型的经典TDT检验的统计等价性
Tanushree Haldar,Saurabh Ghosh
Tanushree Haldar
Clinical end-point traits are usually governed by quantitative precursors. Hence, there is active research interest in developing statistical methods for association mapping of quantitative traits. Unlike population-based tests for associat...
Chalcone synthase genes from milk thistle (Silybum marianum): isolation and expression analysis [0.03%]
乳蓟( Silybum marianum )茋合成酶基因的分离及表达分析
Sepideh Sanjari,Zahra Sadat Shobbar,Mohsen Ebrahimi et al.
Sepideh Sanjari et al.
Silymarin is a flavonoid compound derived from milk thistle (Silybum marianum) seeds which has several pharmacological applications. Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids; thereby, the identification of C...
Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes [0.03%]
通过全局谱型、网络分析以及关键候选基因的独立验证来理解冠状动脉疾病中的基因表达状况
Prathima Arvind,Shanker Jayashree,Srikarthika Jambunathan et al.
Prathima Arvind et al.
Molecular mechanism underlying the patho-physiology of coronary artery disease (CAD) is complex. We used global expression profiling combined with analysis of biological network to dissect out potential genes and pathways associated with CA...
Christine M Disteche,Joel B Berletch
Christine M Disteche
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of ...
Understanding sex determination in the mouse: genetics, epigenetics and the story of mutual antagonisms [0.03%]
从基因和表观遗传学角度理解小鼠性别决定：相互抑制理论的故事
Andy Greenfield
Andy Greenfield
Recent years have seen a rapid growth in mouse genetics resources that support research into fundamental mechanisms in organogenesis, including those controlling mammalian sex determinations. Numerous mouse mutants have shed light on molecu...
Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation [0.03%]
哺乳动物和果蝇的长链非编码RNA在X染色体重构中的发散作用达到相同的效果：剂量补偿
Subhash C Lakhotia
Subhash C Lakhotia
Organisms with heterochromatic sex chromosomes need to compensate for differences in dosages of the sex chromosome-linked genes that have somatic functions. In-depth cytological and subsequent biochemical and molecular studies on dosage com...
Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation [0.03%]
奇异的哺乳动物为哺乳动物性染色体演化和剂量补偿提供线索
Jennifer A Marshall Graves
Jennifer A Marshall Graves
The deep divergence of mammalian groups 166 and 190 million years ago (MYA) provide genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. With encouragement from the found...
Mary Lyon's X-inactivation studies in the mouse laid the foundation for the field of mammalian dosage compensation [0.03%]
玛丽·利昂的X染色体失活研究奠定了哺乳动物剂量补偿领域的基础
Stanley M Gartler
Stanley M Gartler
Expansion of polyalanine tracts in the QA domain may play a critical role in the clavicular development of cleidocranial dysplasia [0.03%]
QA结构域聚 alan 段的扩增可能在颅骨发育不全性锁骨发育不全的锁骨发育中起关键作用
Li-Zheng Wu,Xin-Yue Xu,Ying-Feng Liu et al.
Li-Zheng Wu et al.