Generation of albino C57BL/6J mice by CRISPR embryo editing of the mouse tyrosinase locus [0.03%]
利用CRISPR胚胎编辑技术在小鼠TYR基因座生成白化C57BL/6J品系
M Kasim Diril,Kerem Esmen,Tugba Sehitogullari et al.
M Kasim Diril et al.
After the arrival of the CRISPR/Cas9 genome editing technology, genetic engineering of model organisms has become much faster and more efficient. The development of genetically modified mouse models is also facilitated by the application of...
Gonadal mosaicism and paradoxical phenotype in NEXMIF encephalopathy: a case report of two siblings [0.03%]
NEXMIF脑病的性腺嵌合体和矛盾表型的病例报告：两兄弟姐妹的病例报告
Naik Adarsha,Haseena Sait
Naik Adarsha
The neurite extension and migration factor (NEXMIF) encephalopathy is an X-linked disorder that is characterized by intellectual disability, behavioural abnormalities and seizures. The majority of pathogenic variants are de novo. Here, we r...
Case Reports
Journal of genetics. 2025:104:6. DOI: 2025
Maternal effect on the inheritance of pericarp colour and grain dimension in rice (Oryza sativa L.) [0.03%]
稻谷皮层颜色和谷粒大小母体效应的研究(Oryza sativa L.)
Sakthi Anand Muthazhagu Kuppuraj,Yoglakshmi Chokkalingam,Karthick Jothiganapathy et al.
Sakthi Anand Muthazhagu Kuppuraj et al.
This study aimed to understand the maternal influence on the inheritance of pericarp colour and grain dimensions in rice, serving as a model for maternal effects in plants. Four crosses, namely Kalarata (red pericarp) x DRR Dhan 58 (white p...
The sev-Gal4 driver in Drosophila melanogaster does not express in the eight pairs of dorsomedial and some other neurons in larval ventral ganglia: a correction [0.03%]
在黑腹果蝇中，sev-Gal4启动子并不在幼虫腹神经索的八对背内侧及其他一些神经元中表达：勘误
Vanshika Kaushik,Subhash C Lakhotia
Vanshika Kaushik
The sev-Gal4 driver is widely used in Drosophila to express the target gene in specific subsets of cells in ommatidial units of the developing eye. A 2015 report (Ray and Lakhotia, J. Genet. 94, 407-416) from our laboratory claimed that bes...
YY1 as a mediator to enhance the resistance of KRAS mutant colorectal cancer cells to cetuximab [0.03%]
YY1作为介导因子增强KRAS突变型结肠癌细胞对西妥昔单抗的耐药性
Yi Ma,Yi Lin,Congying Wang et al.
Yi Ma et al.
Cetuximab has been indicated as the mainstay of metastatic colorectal cancer (CRC) therapy, of which application was impeded by chemoresistance that was casually attributed to KRAS mutation. This study sought to determine whether YY1 mediat...
JAG1 overexpression partially rescues muscle function in a zebrafish model of duchenne muscular dystrophy [0.03%]
JAG1过表达部分挽救了杜氏肌营养不良斑马鱼模型的肌肉功能
Vishakha Nesari,Suresh Balakrishnan,Upendra Nongthomba
Vishakha Nesari
Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration and loss of function due to the absence of dystrophin. In this study, we utilized a zebrafish model with a dmd gene knockout to ...
Durgadas P Kasbekar
Durgadas P Kasbekar
The Neurospora crassa fmf-1 mutant has a unique phenotype. It arrests sexual development when the fruiting bodies (perithecia) attain only 40% of their normal diameter, regardless of whether the mutant participates in a cross with the wild ...
Review
Journal of genetics. 2025:104:1. DOI: 2025
Mitochondrial control region sequences show high genetic connectivity in the brownstripe snapper, Lutjanus vitta (Quoy and Gaimard, 1824) from the east coast of Peninsular Malaysia [0.03%]
马来西亚半岛东海岸褐带拟副泥鱼（Lutjanus vitta）线粒体控制区序列的遗传联系分析
Ahasan Habib,Nor Athirah Husna Ahmad,Nur Asma Ariffin et al.
Ahasan Habib et al.
The Brownstripe Snapper, Lutjanus vitta (Quoy and Gaimard, 1824) is a commercially important snapper extensively caught in Malaysia. We examined genetic diversity, population connectivity, and historical demographics of the L. vitta, off th...
The complete mitochondrial genome of the deep-sea methanotrophic sponges Hymedesmia methanophila and Iophon methanophila: leveraging 'waste' in metagenomic data [0.03%]
深海产甲烷海绵Hymedesmia methanophila和Iophon methanophila的完整线粒体基因组：利用宏基因组数据中的“废物”
Dora de Moura Barbosa Leite,Thiago Silva de Paula,Eduardo Hajdu
Dora de Moura Barbosa Leite
A significant proportion of next-generation sequencing (NGS) data ends up not being used since they comprise information out-of-scope of the primary studies. This 'waste' of potential can be harnessed to explore organellar genomes, such as ...
Development of specific molecular markers for medicinal peony (Paeonia lactiflora) with double flower [0.03%]
药用牡丹复瓣花特异分子标记的鉴定与开发
Jinqiu Liao,Shuai Zhang,Qunqun Yang et al.
Jinqiu Liao et al.
In China, medicinal Paeonia lactiflora with double flowers (DFs) does not produce seeds, yet it possesses significantly higher paeoniflorin content compared with its single-flowered counterpart. The propagation of medicinal P. lactiflora wi...