Neuregulin-1, in a Conducive Milieu with Wnt/BMP/Retinoic Acid, Prolongs the Epicardial-Mediated Cardiac Regeneration Capacity of Neonatal Heart Explants [0.03%]
在神经调节素-1与Wnt/BMP/视黄酸的有利微环境中，新生心脏组织块中 epicardium介导的心脏再生潜能得以延长
Himanshu Arora,Alessia C Lavin,Wayne Balkan et al.
Himanshu Arora et al.
Rationale: Cardiac sympathetic nerves are required for endogenous repair of the mammalian neonatal heart in vivo, but the underlying mechanism is unclear. Objective: We tested the hypothesis that a combination of cardiac developmental growt...
A Single-Blinded Randomized Controlled Trial of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee with Active Control [0.03%]
单盲随机对照I期临床试验研究间充质干细胞治疗膝关节骨性关节炎的有效性和安全性：含安慰剂控制组
Joseph J Ruane,Andrew Ross,Victoria Zigmont et al.
Joseph J Ruane et al.
Background: Osteoarthritis is most prevalent in the knee and drives the growing incidence of total knee arthroplasty. There is a need to explore non-surgical treatment options to increase the portfolio of alternatives available. The study a...
Francis P Xavier
Francis P Xavier
Any crisis (personal or collective) brings along an in-built stress. It cripples people from living a normal life; sometimes it leads people to the extreme condition of permanent damage. The COVID-19 situation has brought in unexpected mise...
I. How can you choose the fate of iPSCs and stem cells, Regeneration or Carcinogenesis? A hypothetical insight.: II. Modelling human beta cell development with pluripotent stem cells [0.03%]
:I.如何选择诱导多能干细胞和干细胞的命运：再生还是癌变？一个假设的见解；II.用多能干细胞模拟人类β细胞发育
Masaharu Seno,Maria Cristina Nostro
Masaharu Seno
It is nowadays taken granted that induced pluripotent stem cells (iPSCs) are available for the regeneration therapy since iPSCs differentiate into any kind of phenotypes. If iPSCs can choose their fate in every way of differentiation why th...
Role of autophagy in regulation of glioma stem cells population during therapeutic stress [0.03%]
自噬在胶质瘤干细胞群体治疗压力调节中的作用
Sabiya Abbas,Suraj Kumar Singh,Ajit Kumar Saxena et al.
Sabiya Abbas et al.
Glioblastoma is highly recurrent and aggressive tumor with poor prognosis where existence of glioma stem cell (GSCs) population is well established. The GSCs display stem cell properties such as self-renewable, proliferation and therapeutic...
MSC-released TGF-β regulate α-SMA expression of myofibroblast during wound healing [0.03%]
MSC释放的TGF-β在伤口愈合过程中调控肌成纤维细胞α-SMA的表达
Agung Putra,Iffan Alif,Nurfitriani Hamra et al.
Agung Putra et al.
Objective: Wound healing without fibrosis remains a clinical challenge and a new strategy to promote the optimal wound healing is needed. Mesenchymal stem cells (MSCs) can completely regenerate tissue injury due to the robust MSCs ability i...
Differentiation of Human Deceased Donor, Adipose-Derived, Mesenchymal Stem Cells into Functional Beta Cells [0.03%]
人遗体捐赠的脂肪来源间充质干细胞向功能性β细胞分化
Prakash Rao,Dayanand Deo,Misty Marchioni
Prakash Rao
There is an emerging need for the rapid generation of functional beta cells that can be used in cell replacement therapy for the treatment of type 1 diabetes (T1D). Differentiation of stem cells into insulin-producing cells provides a promi...
Optimizing the in vitro colony-forming assay for more efficient delineation of the interaction between lung epithelial stem cells and their niche [0.03%]
优化体外集落形成测定法以更高效地阐明肺上皮干细胞与其生态位之间的相互作用
Mari Ozaki,Shizuko Kagawa,Makoto Ishii et al.
Mari Ozaki et al.
The use of in vitro 3D organoid/colony forming assay (CFA); which mimics the in vivo environment have provided insight into the mechanisms by which lung stem cells maintain and repair the lung. In recent years, the use of CFA has markedly e...
The Osteogenetic Potential of Chitosan Coated Implant: An In Vitro Study [0.03%]
壳聚糖涂覆种植体的成骨潜能：一项体外研究
Banna M Alnufaiy,Rhodanne Nicole A Lambarte,Khalid S Al-Hamdan
Banna M Alnufaiy
Objective: Chitosan is a promising polymer that has been used for coating dental implants. However, research concerning coatings with implant surfaces other than commercially pure titanium is limited. Therefore, this study aims to clarify t...