Sub-chronic safety evaluation of ayurvedic immunostimulant formulation 'immuforte' in rats in reverse pharmacology [0.03%]
基于反向药理学的免疫刺激方剂“Immuforte”对大鼠亚慢性安全评价研究
Rohit Dhumal,Prakash Patil,Nilakash Selkar et al.
Rohit Dhumal et al.
Objective: The present study was undertaken to determine target organ safety of "Immuforte" to establish relationship between dose or exposure and response and also to identify potential parameters for monitoring adverse ...
Safety Assessment of TLPL/AY/03/2008, A Polyherbal Formulation in Sprague Dawley Rats [0.03%]
TLPL/AY/03/2008复方草药的安全性评价
K R Raghunatha Reddy,S N Vinaya Babu,N Raghavendra et al.
K R Raghunatha Reddy et al.
Objectives: TLPL/AY/03/2008 is a polyherbal formulation intended for treatment of osteoarthritis, rheumatoid arthritis, lumbago, spondylitis etc., Acute and repeated dose 90-days studies were conducted to evaluate the saf...
Effect of sodium valproate on the toxicity of cyclophosphamide in the testes of mice: influence of pre- and post-treatment schedule [0.03%]
丙戊酸钠对小鼠环磷酰胺睾丸毒性的效应及给药时程的影响
S Khan,G B Jena
S Khan
Recently, sodium valproate (VPA) has been proven as histone deacetylase (HDAC) inhibitor and potentiates the cytotoxicity of anticancer drugs, and also exhibit promising anti-cancer activity. Present study aimed to investigate the influence...
Acute oral toxicity and histopathological study of combination of endosulfan and cypermethrin in wistar rats [0.03%]
恩索fan和西维因联合急性口服毒性及组织学损伤研究
Jaya Raj,Mohineesh,Ruma Ray et al.
Jaya Raj et al.
Background: Endosulfan, a neurotoxic organochlorine insecticide and cypermethrin, a synthetic pyrethroid insecticide used to control pests in domestic, industrial, and agricultural situations. ...
Induction of chronic renal failure in goats using Cisplatin: a new animal model [0.03%]
大剂量顺铂诱导山羊慢性肾衰竭的新动物模型
Akhilesh Mishra,Uaday Sankar Chatterjee,Tapan Kumar Mandal
Akhilesh Mishra
Cisplatin was administered at the dose rate of 30 mg m(-2) daily intravenously consecutive for 7 days in goats. Blood samples (2 ml) were collected from each goat at '0' hr and then at weekly interval and centrifuged immediately at 3000 rpm...
Trans-resveratrol restores the damages induced by organophosphate pesticide-monocrotophos in neuronal cells [0.03%]
茋的反式结构体可修复单硫酸磷酰亚胺诱导的神经细胞损伤
Vivek Kumar,Vinay K Tripathi,Abhishek K Singh et al.
Vivek Kumar et al.
The restorative potential of trans-resveratrol (RV) was investigated in a rat neuronal cell line (PC12) exposed to organophosphate pesticide-monocrotophos (MCP). RV shows significant protection against MCP-induced alterations in PC12 cells ...
Evidence against protective role of sex hormone estrogen in Cisplatin-induced nephrotoxicity in ovarectomized rat model [0.03%]
卵巢切除大鼠模型中雌激素不发挥保护作用的证据用于顺铂所致肾毒性的研究
Zahra Pezeshki,Mehdi Nematbakhsh,Hamid Nasri et al.
Zahra Pezeshki et al.
Background: Cisplatin (CP) is an effective drug in cancer therapy to treat the solid tumors, but it is accompanied with nephrotoxicity. The protective effect of estrogen in cardiovascular diseases is well-documented; but ...
Farnesol protects against intratracheally instilled cigarette smoke extract-induced histological alterations and oxidative stress in prostate of wistar rats [0.03%]
法尼醇对大鼠前列腺内给予香烟烟雾提取物引起的组织学改变和氧化应激的保护作用
Abdul Lateef,Muneeb U Rehman,Mir Tahir et al.
Abdul Lateef et al.
Background: In the present study, cigarette smoke contains more than four thousand chemicals, many of which are known to be carcinogen or cancer promoter. Many epidemiological reports suggest that cigarette smokers are at...
Raafat A Mandour
Raafat A Mandour
This study conducted on 423 inhabitant (372 adults and 51 children) blood samples were collected from patients hosted in the Emergency Hospital of Mansoura University. The clinical diagnosis of such patients was acute insecticides poisoning...
Comparative hematoxicity of fusirium mycotoxin in experimental sprague-dawley rats [0.03%]
伏丝瑞毒素的血液毒性及对大鼠血细胞的影响研究
Pronobesh Chattopadhyay,Aadesh Upadhyay,Amit Agnihotri et al.
Pronobesh Chattopadhyay et al.
Mycotoxins are fungal toxin and contaminated to human through food-stuffs. Hematological abnormality, mainly thrombocytopenia and leukopenia are induced after consumption of mycotoxin. Experiments were conducted to evaluate the hematotoxici...