D D O&#x;Leary,D G Wilkinson
D D O&#x;Leary
Ephrins, ligands for the Eph family of receptor tyrosine kinases, are pivotal players in many developmental phenomena in both the central and peripheral nervous systems. Ephrins appear to act typically, but not exclusively, as repellents th...
A B Chitnis
A B Chitnis
Two types of genes activated by neural inducers have been identified, those that lead to the activation of proneural genes and those that limit the activity of these genes to specific domains in the neural plate. The analysis of these genes...
D M Lin,J Ngai
D M Lin
Olfactory receptor neurons project from the sensory epithelium to stereotyped targets within the olfactory bulb. Recent studies suggest that the generation of this precise spatial map probably involves a hierarchy of guidance events, as rec...
D D Francis,M J Meaney
D D Francis
Studies dating from the 1950s have documented the impact of early life events on the development of behavioral and endocrine responses to stress. Recent findings suggest that these effects are mediated through changes in mother-offspring in...
Gene regulation by patterned electrical activity during neural and skeletal muscle development [0.03%]
神经和骨骼肌发育过程中模式化电活动介导的基因调控
A Buonanno,R D Fields
A Buonanno
Patterned neural activity modifies central synapses during development and the physiological properties of skeletal muscle by selectively repressing or stimulating transcription of distinct genes. The effects of neural activity are mostly m...
S Temple,A Alvarez-Buylla
S Temple
Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the ...
M C Crair
M C Crair
Experimental studies over the past year have shown that neural activity has a range of effects on the development of neural pathways. Although activity appears unimportant for establishing many aspects of the gross morphology and topology o...
E M Schuman
E M Schuman
Examples of signaling molecules that are devoted to neuronal development at the exclusion of other functions are scarce. It may then come as no surprise to learn that a family of molecules that promote neuronal survival, differentiation and...
J R Sanes,M Yamagata
J R Sanes
In many parts of the vertebrate central nervous system, inputs of distinct types confine their synapses to individual laminae. Such laminar specificity is a major determinant of synaptic specificity. Recent studies of several laminated stru...
The origin of spontaneous activity in developing networks of the vertebrate nervous system [0.03%]
脊椎动物神经系统发育过程中自主活动的起源
M J O&#x;Donovan
M J O&#x;Donovan
Spontaneous neuronal activity has been detected in many parts of the developing vertebrate nervous system. Recent studies suggest that this activity depends on properties that are probably shared by all developing networks. Of particular im...